Strawberry Intake Ameliorates Oxidative Stress and Decreases GABA Levels Induced by High-Fat Diet in Frontal Cortex of Rats
It has been proposed that there is a correlation between high-fat diet (HFD), oxidative stress and decreased γ-aminobutyric acid (GABA) levels, but this has not been thoroughly demonstrated. In the present study, we determined the effects of strawberry extract intake on the oxidative stress...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-03-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/8/3/70 |
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| author | Cuauhtémoc Sandoval-Salazar Cecilia I. Oviedo-Solís Edmundo Lozoya-Gloria Herlinda Aguilar-Zavala Martha S. Solís-Ortiz Victoriano Pérez-Vázquez Cristina D. Balcón-Pacheco Joel Ramírez-Emiliano |
| author_facet | Cuauhtémoc Sandoval-Salazar Cecilia I. Oviedo-Solís Edmundo Lozoya-Gloria Herlinda Aguilar-Zavala Martha S. Solís-Ortiz Victoriano Pérez-Vázquez Cristina D. Balcón-Pacheco Joel Ramírez-Emiliano |
| author_sort | Cuauhtémoc Sandoval-Salazar |
| collection | DOAJ |
| description | It has been proposed that there is a correlation between high-fat diet (HFD), oxidative stress and decreased γ-aminobutyric acid (GABA) levels, but this has not been thoroughly demonstrated. In the present study, we determined the effects of strawberry extract intake on the oxidative stress and GABA levels in the frontal cortex (FC) of obese rats. We observed that an HFD increased lipid and protein oxidation, and decreased GABA levels. Moreover, UV-irradiated strawberry extract (UViSE) decreased lipid peroxidation but not protein oxidation, whereas non-irradiated strawberry extract (NSE) reduced protein oxidation but not lipid peroxidation. Interestingly, NSE increased GABA concentration, whereas UViSE was not as effective. In conclusion, our results suggest that an HFD increases oxidative damage in the FC, whereas strawberry extract intake may ameliorate the disturbances associated with HFD-induced oxidative damage. |
| first_indexed | 2024-03-12T10:28:43Z |
| format | Article |
| id | doaj.art-64f5d4b099fa4fc7b62193140c4503fa |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T10:28:43Z |
| publishDate | 2019-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-64f5d4b099fa4fc7b62193140c4503fa2023-09-02T09:24:09ZengMDPI AGAntioxidants2076-39212019-03-01837010.3390/antiox8030070antiox8030070Strawberry Intake Ameliorates Oxidative Stress and Decreases GABA Levels Induced by High-Fat Diet in Frontal Cortex of RatsCuauhtémoc Sandoval-Salazar0Cecilia I. Oviedo-Solís1Edmundo Lozoya-Gloria2Herlinda Aguilar-Zavala3Martha S. Solís-Ortiz4Victoriano Pérez-Vázquez5Cristina D. Balcón-Pacheco6Joel Ramírez-Emiliano7Departamento de Enfermería y Obstetricia, División de Ciencias de Salud e Ingenierías, Campus Celaya-Salvatierra, Universidad de Guanajuato, Celaya 38060, MexicoDepartamento de Medicina y Nutrición, Universidad de Guanajuato, León 37672, MexicoLaboratorio de Bioquímica y Biología Molecular de Productos Naturales de Plantas, CINVESTAV, Irapuato 36821, MexicoDepartamento de Enfermería y Obstetricia, División de Ciencias de Salud e Ingenierías, Campus Celaya-Salvatierra, Universidad de Guanajuato, Celaya 38060, MexicoDepartamento de Ciencias Médicas, División de Ciencias de la Salud, Campus León, Universidad de Guanajuato, León 37320, MéxicoDepartamento de Ciencias Médicas, División de Ciencias de la Salud, Campus León, Universidad de Guanajuato, León 37320, MéxicoDepartamento de Ciencias Médicas, División de Ciencias de la Salud, Campus León, Universidad de Guanajuato, León 37320, MéxicoDepartamento de Ciencias Médicas, División de Ciencias de la Salud, Campus León, Universidad de Guanajuato, León 37320, MéxicoIt has been proposed that there is a correlation between high-fat diet (HFD), oxidative stress and decreased γ-aminobutyric acid (GABA) levels, but this has not been thoroughly demonstrated. In the present study, we determined the effects of strawberry extract intake on the oxidative stress and GABA levels in the frontal cortex (FC) of obese rats. We observed that an HFD increased lipid and protein oxidation, and decreased GABA levels. Moreover, UV-irradiated strawberry extract (UViSE) decreased lipid peroxidation but not protein oxidation, whereas non-irradiated strawberry extract (NSE) reduced protein oxidation but not lipid peroxidation. Interestingly, NSE increased GABA concentration, whereas UViSE was not as effective. In conclusion, our results suggest that an HFD increases oxidative damage in the FC, whereas strawberry extract intake may ameliorate the disturbances associated with HFD-induced oxidative damage.https://www.mdpi.com/2076-3921/8/3/70high-fat dietrat frontal cortexγ-aminobutyric acidoxidative stress |
| spellingShingle | Cuauhtémoc Sandoval-Salazar Cecilia I. Oviedo-Solís Edmundo Lozoya-Gloria Herlinda Aguilar-Zavala Martha S. Solís-Ortiz Victoriano Pérez-Vázquez Cristina D. Balcón-Pacheco Joel Ramírez-Emiliano Strawberry Intake Ameliorates Oxidative Stress and Decreases GABA Levels Induced by High-Fat Diet in Frontal Cortex of Rats Antioxidants high-fat diet rat frontal cortex γ-aminobutyric acid oxidative stress |
| title | Strawberry Intake Ameliorates Oxidative Stress and Decreases GABA Levels Induced by High-Fat Diet in Frontal Cortex of Rats |
| title_full | Strawberry Intake Ameliorates Oxidative Stress and Decreases GABA Levels Induced by High-Fat Diet in Frontal Cortex of Rats |
| title_fullStr | Strawberry Intake Ameliorates Oxidative Stress and Decreases GABA Levels Induced by High-Fat Diet in Frontal Cortex of Rats |
| title_full_unstemmed | Strawberry Intake Ameliorates Oxidative Stress and Decreases GABA Levels Induced by High-Fat Diet in Frontal Cortex of Rats |
| title_short | Strawberry Intake Ameliorates Oxidative Stress and Decreases GABA Levels Induced by High-Fat Diet in Frontal Cortex of Rats |
| title_sort | strawberry intake ameliorates oxidative stress and decreases gaba levels induced by high fat diet in frontal cortex of rats |
| topic | high-fat diet rat frontal cortex γ-aminobutyric acid oxidative stress |
| url | https://www.mdpi.com/2076-3921/8/3/70 |
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