Metabolic syndrome is associated with peripheral endothelial dysfunction amongst men
Riad Taher,1 Jaskanwal D Sara,1 Behnam Heidari,1 Takumi Toya,1 Lilach O Lerman,2 Amir Lerman11Division of Cardiovascular Diseases, Mayo Clinic College of Medicine and Science, Rochester, MN, USA; 2Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic College of Medicine and Sc...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-07-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
| Subjects: | |
| Online Access: | https://www.dovepress.com/metabolic-syndrome-is-associated-with-peripheral-endothelial-dysfuncti-peer-reviewed-article-DMSO |
| _version_ | 1797935250832097280 |
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| author | Taher R Sara JD Heidari B Toya T Lerman LO Lerman A |
| author_facet | Taher R Sara JD Heidari B Toya T Lerman LO Lerman A |
| author_sort | Taher R |
| collection | DOAJ |
| description | Riad Taher,1 Jaskanwal D Sara,1 Behnam Heidari,1 Takumi Toya,1 Lilach O Lerman,2 Amir Lerman11Division of Cardiovascular Diseases, Mayo Clinic College of Medicine and Science, Rochester, MN, USA; 2Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USAPurpose: Metabolic syndrome (MetS) and peripheral endothelial dysfunction (PED) are both independently associated with an increased risk of cardiovascular disease (CVD). PED provides prognostic information beyond that provided by conventional risk factors. However, the association between MetS and PED remains uncertain. We evaluated the association between MetS and PED.Patients and methods: We performed a retrospective analysis of patients who were referred to Mayo Clinic between 2006 and 2014 for evaluation of chest pain and/or an assessment of CVD risk that included an assessment of PED measured with reactive hyperemia peripheral arterial tonometry. MetS was defined as the presence of at least 3 of the following: body mass index≥25 kg/m,2 impaired fasting glucose or diabetes, high blood pressure or hypertension, hypertriglyceridemia, or low high-density lipoprotein cholesterol.Results: Six hundred seventy-eight patients were included (mean age 51.9±13.5 years, 418 (61.6%) women), of which 293 (43.2%) had PED, and 249 (36.7%) had MetS. In multivariable analyses adjusted for age, sex, CVD, smoking status, and elevated low-density lipoprotein, MetS was significantly associated with PED (Odds Ratio (OR) 2.06; P=0.0090). Of the individual MetS components, only being overweight and MetS range high-density lipoprotein had a similar association. After stratifying by sex, the association between MetS and PED persisted only in men (OR 3.16, P=0.0094).Conclusions: MetS is associated with PED in men undergoing an assessment of chest pain and/or CVD risk. Identifying PED in individuals with MetS could provide an abridged assessment of risk, potentially allowing for earlier and more intensive management of risk factors.Keywords: metabolic syndrome, peripheral endothelial dysfunction, reactive hyperemia peripheral arterial tonometry, cardiovascular disease |
| first_indexed | 2024-04-10T18:11:27Z |
| format | Article |
| id | doaj.art-64f6b40a701d461fa1f16d97806d0d72 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T18:11:27Z |
| publishDate | 2019-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-64f6b40a701d461fa1f16d97806d0d722023-02-02T10:41:26ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072019-07-01Volume 121035104546895Metabolic syndrome is associated with peripheral endothelial dysfunction amongst menTaher RSara JDHeidari BToya TLerman LOLerman ARiad Taher,1 Jaskanwal D Sara,1 Behnam Heidari,1 Takumi Toya,1 Lilach O Lerman,2 Amir Lerman11Division of Cardiovascular Diseases, Mayo Clinic College of Medicine and Science, Rochester, MN, USA; 2Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USAPurpose: Metabolic syndrome (MetS) and peripheral endothelial dysfunction (PED) are both independently associated with an increased risk of cardiovascular disease (CVD). PED provides prognostic information beyond that provided by conventional risk factors. However, the association between MetS and PED remains uncertain. We evaluated the association between MetS and PED.Patients and methods: We performed a retrospective analysis of patients who were referred to Mayo Clinic between 2006 and 2014 for evaluation of chest pain and/or an assessment of CVD risk that included an assessment of PED measured with reactive hyperemia peripheral arterial tonometry. MetS was defined as the presence of at least 3 of the following: body mass index≥25 kg/m,2 impaired fasting glucose or diabetes, high blood pressure or hypertension, hypertriglyceridemia, or low high-density lipoprotein cholesterol.Results: Six hundred seventy-eight patients were included (mean age 51.9±13.5 years, 418 (61.6%) women), of which 293 (43.2%) had PED, and 249 (36.7%) had MetS. In multivariable analyses adjusted for age, sex, CVD, smoking status, and elevated low-density lipoprotein, MetS was significantly associated with PED (Odds Ratio (OR) 2.06; P=0.0090). Of the individual MetS components, only being overweight and MetS range high-density lipoprotein had a similar association. After stratifying by sex, the association between MetS and PED persisted only in men (OR 3.16, P=0.0094).Conclusions: MetS is associated with PED in men undergoing an assessment of chest pain and/or CVD risk. Identifying PED in individuals with MetS could provide an abridged assessment of risk, potentially allowing for earlier and more intensive management of risk factors.Keywords: metabolic syndrome, peripheral endothelial dysfunction, reactive hyperemia peripheral arterial tonometry, cardiovascular diseasehttps://www.dovepress.com/metabolic-syndrome-is-associated-with-peripheral-endothelial-dysfuncti-peer-reviewed-article-DMSOMetabolic syndromeperipheral endothelial dysfunctionReactive Hyperemia Peripheral Arterial Tonometrycardiovascular disease |
| spellingShingle | Taher R Sara JD Heidari B Toya T Lerman LO Lerman A Metabolic syndrome is associated with peripheral endothelial dysfunction amongst men Diabetes, Metabolic Syndrome and Obesity Metabolic syndrome peripheral endothelial dysfunction Reactive Hyperemia Peripheral Arterial Tonometry cardiovascular disease |
| title | Metabolic syndrome is associated with peripheral endothelial dysfunction amongst men |
| title_full | Metabolic syndrome is associated with peripheral endothelial dysfunction amongst men |
| title_fullStr | Metabolic syndrome is associated with peripheral endothelial dysfunction amongst men |
| title_full_unstemmed | Metabolic syndrome is associated with peripheral endothelial dysfunction amongst men |
| title_short | Metabolic syndrome is associated with peripheral endothelial dysfunction amongst men |
| title_sort | metabolic syndrome is associated with peripheral endothelial dysfunction amongst men |
| topic | Metabolic syndrome peripheral endothelial dysfunction Reactive Hyperemia Peripheral Arterial Tonometry cardiovascular disease |
| url | https://www.dovepress.com/metabolic-syndrome-is-associated-with-peripheral-endothelial-dysfuncti-peer-reviewed-article-DMSO |
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