| Summary: | <b>Aims and Objectives:</b> The aim of the present study was to investigate systemic levels of inflammatory markers of cardiovascular diseases like C-reactive protein and interleukin-6 in patients with chronic periodontitis, in comparison to periodontally healthy individuals. <b> Materials and Methods:</b> A total of 42 individuals, both males and females above the age of 30 years, were included in the study. Healthy controls (Group I, <i>n</i> = 14), chronic localized periodontitis (Group II, <i>n</i> = 14), and chronic generalized periodontitis (Group III, <i>n</i> = 14), all without any medical disorder, were recruited. Peripheral blood samples were taken and C-reactive protein (CRP) levels were estimated in the serum samples by using the Particle-Enhanced Turbidimetric Immunoassay (PETIA) technique. Serum samples of Interleukin-6 (IL-6) were assayed by using the Chemiluminescent Immunoassay (IMMULITE) technique. <b> Results:</b> When mean CRP levels were compared between the groups, group III showed statistical significance when compared to group I (<i>P</i> = 0.04). Group III had a higher median IL-6 level (6.35 pg/mL) than Group II (< 5.0 pg/ mL) and group I (< 5.0 pg/mL). Differences in median values of IL-6 were not statistically significant in any group (<i>P</i> = 0.29). <b> Conclusion:</b> Periodontitis results in higher systemic levels of CRP and IL-6. These elevated inflammatory factors may increase inflammatory activity in atherosclerotic lesions and potentially increasing the risk for cardiovascular events.
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