Evaluation of C-reactive protein and interleukin-6 in the peripheral blood of patients with chronic periodontitis
<b>Aims and Objectives:</b> The aim of the present study was to investigate systemic levels of inflammatory markers of cardiovascular diseases like C-reactive protein and interleukin-6 in patients with chronic periodontitis, in comparison to periodontally healthy individuals. <b>...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2009-01-01
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| Series: | Journal of Indian Society of Periodontology |
| Subjects: | |
| Online Access: | http://www.jisponline.com/article.asp?issn=0972-124X;year=2009;volume=13;issue=2;spage=69;epage=74;aulast=Gani |
| _version_ | 1818215122922897408 |
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| author | Gani Dhruva Lakshmi Deepa Krishnan Rama Emmadi Pamela |
| author_facet | Gani Dhruva Lakshmi Deepa Krishnan Rama Emmadi Pamela |
| author_sort | Gani Dhruva |
| collection | DOAJ |
| description | <b>Aims and Objectives:</b> The aim of the present study was to investigate systemic levels of inflammatory markers of cardiovascular diseases like C-reactive protein and interleukin-6 in patients with chronic periodontitis, in comparison to periodontally healthy individuals. <b> Materials and Methods:</b> A total of 42 individuals, both males and females above the age of 30 years, were included in the study. Healthy controls (Group I, <i>n</i> = 14), chronic localized periodontitis (Group II, <i>n</i> = 14), and chronic generalized periodontitis (Group III, <i>n</i> = 14), all without any medical disorder, were recruited. Peripheral blood samples were taken and C-reactive protein (CRP) levels were estimated in the serum samples by using the Particle-Enhanced Turbidimetric Immunoassay (PETIA) technique. Serum samples of Interleukin-6 (IL-6) were assayed by using the Chemiluminescent Immunoassay (IMMULITE) technique. <b> Results:</b> When mean CRP levels were compared between the groups, group III showed statistical significance when compared to group I (<i>P</i> = 0.04). Group III had a higher median IL-6 level (6.35 pg/mL) than Group II (< 5.0 pg/ mL) and group I (< 5.0 pg/mL). Differences in median values of IL-6 were not statistically significant in any group (<i>P</i> = 0.29). <b> Conclusion:</b> Periodontitis results in higher systemic levels of CRP and IL-6. These elevated inflammatory factors may increase inflammatory activity in atherosclerotic lesions and potentially increasing the risk for cardiovascular events. |
| first_indexed | 2024-12-12T06:31:04Z |
| format | Article |
| id | doaj.art-64f828baaac945eb9f4fa836e24730b9 |
| institution | Directory Open Access Journal |
| issn | 0972-124X |
| language | English |
| last_indexed | 2024-12-12T06:31:04Z |
| publishDate | 2009-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Indian Society of Periodontology |
| spelling | doaj.art-64f828baaac945eb9f4fa836e24730b92022-12-22T00:34:35ZengWolters Kluwer Medknow PublicationsJournal of Indian Society of Periodontology0972-124X2009-01-011326974Evaluation of C-reactive protein and interleukin-6 in the peripheral blood of patients with chronic periodontitisGani DhruvaLakshmi DeepaKrishnan RamaEmmadi Pamela<b>Aims and Objectives:</b> The aim of the present study was to investigate systemic levels of inflammatory markers of cardiovascular diseases like C-reactive protein and interleukin-6 in patients with chronic periodontitis, in comparison to periodontally healthy individuals. <b> Materials and Methods:</b> A total of 42 individuals, both males and females above the age of 30 years, were included in the study. Healthy controls (Group I, <i>n</i> = 14), chronic localized periodontitis (Group II, <i>n</i> = 14), and chronic generalized periodontitis (Group III, <i>n</i> = 14), all without any medical disorder, were recruited. Peripheral blood samples were taken and C-reactive protein (CRP) levels were estimated in the serum samples by using the Particle-Enhanced Turbidimetric Immunoassay (PETIA) technique. Serum samples of Interleukin-6 (IL-6) were assayed by using the Chemiluminescent Immunoassay (IMMULITE) technique. <b> Results:</b> When mean CRP levels were compared between the groups, group III showed statistical significance when compared to group I (<i>P</i> = 0.04). Group III had a higher median IL-6 level (6.35 pg/mL) than Group II (< 5.0 pg/ mL) and group I (< 5.0 pg/mL). Differences in median values of IL-6 were not statistically significant in any group (<i>P</i> = 0.29). <b> Conclusion:</b> Periodontitis results in higher systemic levels of CRP and IL-6. These elevated inflammatory factors may increase inflammatory activity in atherosclerotic lesions and potentially increasing the risk for cardiovascular events.http://www.jisponline.com/article.asp?issn=0972-124X;year=2009;volume=13;issue=2;spage=69;epage=74;aulast=GaniChemiluminescent immunoassay techniqueC-reactive proteininterleukin-6particle enhanced turbidimetric immunoassay technique |
| spellingShingle | Gani Dhruva Lakshmi Deepa Krishnan Rama Emmadi Pamela Evaluation of C-reactive protein and interleukin-6 in the peripheral blood of patients with chronic periodontitis Journal of Indian Society of Periodontology Chemiluminescent immunoassay technique C-reactive protein interleukin-6 particle enhanced turbidimetric immunoassay technique |
| title | Evaluation of C-reactive protein and interleukin-6 in the peripheral blood of patients with chronic periodontitis |
| title_full | Evaluation of C-reactive protein and interleukin-6 in the peripheral blood of patients with chronic periodontitis |
| title_fullStr | Evaluation of C-reactive protein and interleukin-6 in the peripheral blood of patients with chronic periodontitis |
| title_full_unstemmed | Evaluation of C-reactive protein and interleukin-6 in the peripheral blood of patients with chronic periodontitis |
| title_short | Evaluation of C-reactive protein and interleukin-6 in the peripheral blood of patients with chronic periodontitis |
| title_sort | evaluation of c reactive protein and interleukin 6 in the peripheral blood of patients with chronic periodontitis |
| topic | Chemiluminescent immunoassay technique C-reactive protein interleukin-6 particle enhanced turbidimetric immunoassay technique |
| url | http://www.jisponline.com/article.asp?issn=0972-124X;year=2009;volume=13;issue=2;spage=69;epage=74;aulast=Gani |
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