Alternative and Complementary Therapies against Foodborne Salmonella Infections
The limitations in the therapeutic options for foodborne pathogens lead to treatments failure, especially for multidrug-resistant (MDR) <i>Salmonella</i> sp., worldwide. Therefore, we aimed to find alternative and complementary therapies against these resistant foodborne pathogens. Out o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/10/12/1453 |
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| author | Mohamed F. Ghaly Zahraa M. Nasr Amira I. Abousaty Hanan G. Seadawy Mohamed A. A. Shaheen Sarah Albogami Mohammad M. Al-Sanea Mahmoud M. Bendary |
| author_facet | Mohamed F. Ghaly Zahraa M. Nasr Amira I. Abousaty Hanan G. Seadawy Mohamed A. A. Shaheen Sarah Albogami Mohammad M. Al-Sanea Mahmoud M. Bendary |
| author_sort | Mohamed F. Ghaly |
| collection | DOAJ |
| description | The limitations in the therapeutic options for foodborne pathogens lead to treatments failure, especially for multidrug-resistant (MDR) <i>Salmonella</i> sp., worldwide. Therefore, we aimed to find alternative and complementary therapies against these resistant foodborne pathogens. Out of 100 meat products samples, the prevalence rate of salmonella was 6%, serotyped only as <i>S</i>. <i>Typhimurium</i> and <i>S. Enteritidis</i>. According to the antibiotic susceptibility assays, the majority of our isolates were MDR and susceptible to cefotaxime. Out of the 13 tested plant extracts, five only showed an inhibition zone in the range of 8–50 mm against both serotypes. Based on their promising activity, the oily extract of cinnamon and aqueous extract of paprika represented the highest potency. Surprisingly, a significant synergistic effect was detected between cinnamon oil and cefotaxime. Depending on Gas Chromatography/Mass Spectrometry (GC-MS), the antimicrobial activity of cinnamon oil was attributed to four components including linalool, camphor, (Z)-3-Phenylacrylaldehyde and its stereoisomer 2-Propenal-3-phenyl. The anti-virulence activities of these compounds were confirmed on the basis of computational molecular docking studies. Accordingly, we recommended the use of cinnamon oil as a food additive to fight the resistant foodborne pathogens. Additionally, we confirmed its therapeutic uses, especially when co-administrated with other antimicrobial agents. |
| first_indexed | 2024-03-10T04:39:33Z |
| format | Article |
| id | doaj.art-64f8d717082b4cbf80b2459aa5b1defe |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T04:39:33Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-64f8d717082b4cbf80b2459aa5b1defe2023-11-23T03:30:04ZengMDPI AGAntibiotics2079-63822021-11-011012145310.3390/antibiotics10121453Alternative and Complementary Therapies against Foodborne Salmonella InfectionsMohamed F. Ghaly0Zahraa M. Nasr1Amira I. Abousaty2Hanan G. Seadawy3Mohamed A. A. Shaheen4Sarah Albogami5Mohammad M. Al-Sanea6Mahmoud M. Bendary7Microbiology Department, Faculty of Science, Zagazig University, Zagazig 44511, EgyptMicrobiology Department, Faculty of Science, Zagazig University, Zagazig 44511, EgyptMicrobiology Department, Faculty of Science, Zagazig University, Zagazig 44511, EgyptAgriculture Research Center (ARC), Animal Health Research Institute (AHRI), Zagazig 44511, EgyptClinical Pathology Department, Faculty of Medicine, Al Azhar University, Chairo 11311, EgyptDepartment of Biotechnology, College of Science, Taif University, Taif 21974, Saudi ArabiaPharmaceutical Chemistry Department, College of Pharmacy, Jouf University, Sakaka 72341, Saudi ArabiaMicrobiology and Immunology Department, Faculty of Pharmacy, Port Said University, Port Side 42511, EgyptThe limitations in the therapeutic options for foodborne pathogens lead to treatments failure, especially for multidrug-resistant (MDR) <i>Salmonella</i> sp., worldwide. Therefore, we aimed to find alternative and complementary therapies against these resistant foodborne pathogens. Out of 100 meat products samples, the prevalence rate of salmonella was 6%, serotyped only as <i>S</i>. <i>Typhimurium</i> and <i>S. Enteritidis</i>. According to the antibiotic susceptibility assays, the majority of our isolates were MDR and susceptible to cefotaxime. Out of the 13 tested plant extracts, five only showed an inhibition zone in the range of 8–50 mm against both serotypes. Based on their promising activity, the oily extract of cinnamon and aqueous extract of paprika represented the highest potency. Surprisingly, a significant synergistic effect was detected between cinnamon oil and cefotaxime. Depending on Gas Chromatography/Mass Spectrometry (GC-MS), the antimicrobial activity of cinnamon oil was attributed to four components including linalool, camphor, (Z)-3-Phenylacrylaldehyde and its stereoisomer 2-Propenal-3-phenyl. The anti-virulence activities of these compounds were confirmed on the basis of computational molecular docking studies. Accordingly, we recommended the use of cinnamon oil as a food additive to fight the resistant foodborne pathogens. Additionally, we confirmed its therapeutic uses, especially when co-administrated with other antimicrobial agents.https://www.mdpi.com/2079-6382/10/12/1453<i>Salmonella</i>foodbornecinnamonpaprikacefotaxime |
| spellingShingle | Mohamed F. Ghaly Zahraa M. Nasr Amira I. Abousaty Hanan G. Seadawy Mohamed A. A. Shaheen Sarah Albogami Mohammad M. Al-Sanea Mahmoud M. Bendary Alternative and Complementary Therapies against Foodborne Salmonella Infections Antibiotics <i>Salmonella</i> foodborne cinnamon paprika cefotaxime |
| title | Alternative and Complementary Therapies against Foodborne Salmonella Infections |
| title_full | Alternative and Complementary Therapies against Foodborne Salmonella Infections |
| title_fullStr | Alternative and Complementary Therapies against Foodborne Salmonella Infections |
| title_full_unstemmed | Alternative and Complementary Therapies against Foodborne Salmonella Infections |
| title_short | Alternative and Complementary Therapies against Foodborne Salmonella Infections |
| title_sort | alternative and complementary therapies against foodborne salmonella infections |
| topic | <i>Salmonella</i> foodborne cinnamon paprika cefotaxime |
| url | https://www.mdpi.com/2079-6382/10/12/1453 |
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