Assessment of Glycometabolism Impairment and Glucose Variability Using Flash Glucose Monitoring System in Patients With Adrenal Diseases
BackgroundThis study aimed to investigate the characteristics and extent of glycometabolism impairment in patients with adrenal diseases, including Cushing syndrome, primary aldosteronism, pheochromocytoma, and nonfunctional adrenal incidentaloma.MethodsThis study enrolled thirty-two patients with a...
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2020.544752/full |
| _version_ | 1818047289640353792 |
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| author | Minmin Han Minmin Han Xiaoming Cao Changjian Zhao Luyang Yang Nan Yin Pengliang Shen Jin Zhang Fei Gao Yi Ren Dong Liang Jing Yang Yi Zhang Yunfeng Liu |
| author_facet | Minmin Han Minmin Han Xiaoming Cao Changjian Zhao Luyang Yang Nan Yin Pengliang Shen Jin Zhang Fei Gao Yi Ren Dong Liang Jing Yang Yi Zhang Yunfeng Liu |
| author_sort | Minmin Han |
| collection | DOAJ |
| description | BackgroundThis study aimed to investigate the characteristics and extent of glycometabolism impairment in patients with adrenal diseases, including Cushing syndrome, primary aldosteronism, pheochromocytoma, and nonfunctional adrenal incidentaloma.MethodsThis study enrolled thirty-two patients with adrenal diseases as adrenal disease groups and eight healthy individuals as healthy controls. Blood glucose levels were indicated by glucose concentration in interstitial fluid, which was documented using flash glucose monitoring system. According to flash glucose monitoring system data, parameters representing general blood glucose alterations, within-day and day-to-day glucose variability, and glucose-target-rate were calculated. Furthermore, blood glucose levels at nocturnal, fasting, and postprandial periods were analyzed. Besides, islet β-cell function and insulin resistance were assessed.ResultsAnalysis of flash glucose monitoring system-related parameters indicated impaired glycometabolism in patients with adrenal diseases compared with that of healthy controls at general blood glucose, within-day and day-to-day glucose variability, and glucose-target-rate levels. Furthermore, the dynamic glucose monitoring data revealed that significantly affected blood glucose levels compared with that of healthy controls were observed at postprandial periods in the Cushing syndrome and primary aldosteronism groups; at nocturnal, fasting and postprandial periods in the pheochromocytoma group. Significant insulin resistance and abnormal β-cell function were observed in the Cushing syndrome group compared with that in healthy controls.ConclusionAdrenal diseases can negatively affect glucose metabolism. Patients diagnosed with adrenal diseases should receive timely and appropriate treatment to avoid adverse cardiovascular events linked to hyperglycemia and insulin resistance. |
| first_indexed | 2024-12-10T10:03:26Z |
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| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-10T10:03:26Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-64f979f7f1544bb793610601123b9ecc2022-12-22T01:53:18ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922020-09-011110.3389/fendo.2020.544752544752Assessment of Glycometabolism Impairment and Glucose Variability Using Flash Glucose Monitoring System in Patients With Adrenal DiseasesMinmin Han0Minmin Han1Xiaoming Cao2Changjian Zhao3Luyang Yang4Nan Yin5Pengliang Shen6Jin Zhang7Fei Gao8Yi Ren9Dong Liang10Jing Yang11Yi Zhang12Yunfeng Liu13First Clinical Medical College, Shanxi Medical University, Taiyuan, ChinaDepartment of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Urology, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Urology, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Urology, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Urology, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Pharmacology, Shanxi Medical University, Taiyuan, ChinaDepartment of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan, ChinaBackgroundThis study aimed to investigate the characteristics and extent of glycometabolism impairment in patients with adrenal diseases, including Cushing syndrome, primary aldosteronism, pheochromocytoma, and nonfunctional adrenal incidentaloma.MethodsThis study enrolled thirty-two patients with adrenal diseases as adrenal disease groups and eight healthy individuals as healthy controls. Blood glucose levels were indicated by glucose concentration in interstitial fluid, which was documented using flash glucose monitoring system. According to flash glucose monitoring system data, parameters representing general blood glucose alterations, within-day and day-to-day glucose variability, and glucose-target-rate were calculated. Furthermore, blood glucose levels at nocturnal, fasting, and postprandial periods were analyzed. Besides, islet β-cell function and insulin resistance were assessed.ResultsAnalysis of flash glucose monitoring system-related parameters indicated impaired glycometabolism in patients with adrenal diseases compared with that of healthy controls at general blood glucose, within-day and day-to-day glucose variability, and glucose-target-rate levels. Furthermore, the dynamic glucose monitoring data revealed that significantly affected blood glucose levels compared with that of healthy controls were observed at postprandial periods in the Cushing syndrome and primary aldosteronism groups; at nocturnal, fasting and postprandial periods in the pheochromocytoma group. Significant insulin resistance and abnormal β-cell function were observed in the Cushing syndrome group compared with that in healthy controls.ConclusionAdrenal diseases can negatively affect glucose metabolism. Patients diagnosed with adrenal diseases should receive timely and appropriate treatment to avoid adverse cardiovascular events linked to hyperglycemia and insulin resistance.https://www.frontiersin.org/article/10.3389/fendo.2020.544752/fullglucose metabolism impairmentflash glucose monitoring systemCushing syndromeprimary aldosteronismpheochromocytomanonfunctional adrenal incidentaloma |
| spellingShingle | Minmin Han Minmin Han Xiaoming Cao Changjian Zhao Luyang Yang Nan Yin Pengliang Shen Jin Zhang Fei Gao Yi Ren Dong Liang Jing Yang Yi Zhang Yunfeng Liu Assessment of Glycometabolism Impairment and Glucose Variability Using Flash Glucose Monitoring System in Patients With Adrenal Diseases Frontiers in Endocrinology glucose metabolism impairment flash glucose monitoring system Cushing syndrome primary aldosteronism pheochromocytoma nonfunctional adrenal incidentaloma |
| title | Assessment of Glycometabolism Impairment and Glucose Variability Using Flash Glucose Monitoring System in Patients With Adrenal Diseases |
| title_full | Assessment of Glycometabolism Impairment and Glucose Variability Using Flash Glucose Monitoring System in Patients With Adrenal Diseases |
| title_fullStr | Assessment of Glycometabolism Impairment and Glucose Variability Using Flash Glucose Monitoring System in Patients With Adrenal Diseases |
| title_full_unstemmed | Assessment of Glycometabolism Impairment and Glucose Variability Using Flash Glucose Monitoring System in Patients With Adrenal Diseases |
| title_short | Assessment of Glycometabolism Impairment and Glucose Variability Using Flash Glucose Monitoring System in Patients With Adrenal Diseases |
| title_sort | assessment of glycometabolism impairment and glucose variability using flash glucose monitoring system in patients with adrenal diseases |
| topic | glucose metabolism impairment flash glucose monitoring system Cushing syndrome primary aldosteronism pheochromocytoma nonfunctional adrenal incidentaloma |
| url | https://www.frontiersin.org/article/10.3389/fendo.2020.544752/full |
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