Regulatory Effects of Statins on SIRT1 and Other Sirtuins in Cardiovascular Diseases
Adverse cardiovascular disease (CVD) outcomes, such as sudden cardiac death, acute myocardial infarction, and stroke, are often catastrophic. Statins are frequently used to attenuate the risk of CVD-associated morbidity and mortality through their impact on lipids and they may also have anti-inflamm...
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MDPI AG
2022-05-01
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| Online Access: | https://www.mdpi.com/2075-1729/12/5/760 |
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| author | Danial Khayatan Seyed Mehrad Razavi Zahra Najafi Arab Maryam Khanahmadi Saeideh Momtaz Alexandra E. Butler Fabrizio Montecucco Yuliya V. Markina Amir Hossein Abdolghaffari Amirhossein Sahebkar |
| author_facet | Danial Khayatan Seyed Mehrad Razavi Zahra Najafi Arab Maryam Khanahmadi Saeideh Momtaz Alexandra E. Butler Fabrizio Montecucco Yuliya V. Markina Amir Hossein Abdolghaffari Amirhossein Sahebkar |
| author_sort | Danial Khayatan |
| collection | DOAJ |
| description | Adverse cardiovascular disease (CVD) outcomes, such as sudden cardiac death, acute myocardial infarction, and stroke, are often catastrophic. Statins are frequently used to attenuate the risk of CVD-associated morbidity and mortality through their impact on lipids and they may also have anti-inflammatory and other plaque-stabilization effects via different signaling pathways. Different statins, including atorvastatin, rosuvastatin, pravastatin, pitavastatin, and simvastatin, are administered to manage circulatory lipid levels. In addition, statins are potent inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMGCoA) reductase via modulating sirtuins (SIRTs). During the last two decades, SIRTs have been investigated in mammals and categorized as a family of nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylases (HDACs) with significant oxidative stress regulatory function in cells—a key factor in extending cell lifespan. Recent work has demonstrated that statins upregulate SIRT1 and SIRT2 and downregulate SIRT6 in both in vitro and in vivo experiments and clinical trials. As statins show modulatory properties, especially in CVDs, future investigations are needed to delineate the role of SIRT family members in disease and to expand knowledge about the effects of statins on SIRTs. Here, we review what is currently known about the impact of statins on SIRTs and how these changes correlate with disease, particularly CVDs. |
| first_indexed | 2024-03-10T03:33:46Z |
| format | Article |
| id | doaj.art-64fa6a308966414ebda997719a6f1c3e |
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| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T03:33:46Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-64fa6a308966414ebda997719a6f1c3e2023-11-23T11:51:04ZengMDPI AGLife2075-17292022-05-0112576010.3390/life12050760Regulatory Effects of Statins on SIRT1 and Other Sirtuins in Cardiovascular DiseasesDanial Khayatan0Seyed Mehrad Razavi1Zahra Najafi Arab2Maryam Khanahmadi3Saeideh Momtaz4Alexandra E. Butler5Fabrizio Montecucco6Yuliya V. Markina7Amir Hossein Abdolghaffari8Amirhossein Sahebkar9Department of Toxicology & Pharmacology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, IranDepartment of Toxicology & Pharmacology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, IranDepartment of Toxicology & Pharmacology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, IranDepartment of Toxicology & Pharmacology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, IranMedicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, IranResearch Department, Royal College of Surgeons in Ireland, Adliya P.O. Box 15503, BahrainFirst Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, 16132 Genoa, ItalyLaboratory of Cellular and Molecular Pathology of Cardiovascular System, Avtsyn Research Institute of Human Morphology of FSBI “Petrovsky National Research Center of Surgery”, 3 Tsyurupy Str., 117418 Moscow, RussiaDepartment of Toxicology & Pharmacology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, IranApplied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, IranAdverse cardiovascular disease (CVD) outcomes, such as sudden cardiac death, acute myocardial infarction, and stroke, are often catastrophic. Statins are frequently used to attenuate the risk of CVD-associated morbidity and mortality through their impact on lipids and they may also have anti-inflammatory and other plaque-stabilization effects via different signaling pathways. Different statins, including atorvastatin, rosuvastatin, pravastatin, pitavastatin, and simvastatin, are administered to manage circulatory lipid levels. In addition, statins are potent inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMGCoA) reductase via modulating sirtuins (SIRTs). During the last two decades, SIRTs have been investigated in mammals and categorized as a family of nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylases (HDACs) with significant oxidative stress regulatory function in cells—a key factor in extending cell lifespan. Recent work has demonstrated that statins upregulate SIRT1 and SIRT2 and downregulate SIRT6 in both in vitro and in vivo experiments and clinical trials. As statins show modulatory properties, especially in CVDs, future investigations are needed to delineate the role of SIRT family members in disease and to expand knowledge about the effects of statins on SIRTs. Here, we review what is currently known about the impact of statins on SIRTs and how these changes correlate with disease, particularly CVDs.https://www.mdpi.com/2075-1729/12/5/760sirtuinsstatinscardiovascular diseasesHMGCoA reductase inhibitors |
| spellingShingle | Danial Khayatan Seyed Mehrad Razavi Zahra Najafi Arab Maryam Khanahmadi Saeideh Momtaz Alexandra E. Butler Fabrizio Montecucco Yuliya V. Markina Amir Hossein Abdolghaffari Amirhossein Sahebkar Regulatory Effects of Statins on SIRT1 and Other Sirtuins in Cardiovascular Diseases Life sirtuins statins cardiovascular diseases HMGCoA reductase inhibitors |
| title | Regulatory Effects of Statins on SIRT1 and Other Sirtuins in Cardiovascular Diseases |
| title_full | Regulatory Effects of Statins on SIRT1 and Other Sirtuins in Cardiovascular Diseases |
| title_fullStr | Regulatory Effects of Statins on SIRT1 and Other Sirtuins in Cardiovascular Diseases |
| title_full_unstemmed | Regulatory Effects of Statins on SIRT1 and Other Sirtuins in Cardiovascular Diseases |
| title_short | Regulatory Effects of Statins on SIRT1 and Other Sirtuins in Cardiovascular Diseases |
| title_sort | regulatory effects of statins on sirt1 and other sirtuins in cardiovascular diseases |
| topic | sirtuins statins cardiovascular diseases HMGCoA reductase inhibitors |
| url | https://www.mdpi.com/2075-1729/12/5/760 |
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