Holocue: A Wearable Holographic Cueing Application for Alleviating Freezing of Gait in Parkinson's Disease
External visual cueing is a well-known means to target freezing of gait (FOG) in Parkinson's disease patients. Holocue is a wearable visual cueing application that allows the HoloLens 1 mixed-reality headset to present on-demand patient-tailored action-relevant 2D and 3D holographic visual cues...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2021.628388/full |
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| author | Daphne J. Geerse Daphne J. Geerse Bert Coolen Jacobus J. van Hilten Melvyn Roerdink |
| author_facet | Daphne J. Geerse Daphne J. Geerse Bert Coolen Jacobus J. van Hilten Melvyn Roerdink |
| author_sort | Daphne J. Geerse |
| collection | DOAJ |
| description | External visual cueing is a well-known means to target freezing of gait (FOG) in Parkinson's disease patients. Holocue is a wearable visual cueing application that allows the HoloLens 1 mixed-reality headset to present on-demand patient-tailored action-relevant 2D and 3D holographic visual cues in free-living environments. The aim of this study involving 24 Parkinson's disease patients with dopaminergic “ON state” FOG was two-fold. First, to explore unfamiliarity and habituation effects associated with wearing the HoloLens on FOG. Second, to evaluate the potential immediate effect of Holocue on alleviating FOG in the home environment. Three sessions were conducted to examine (1) the effect of wearing the unfamiliar HoloLens on FOG by comparing walking with and without the HoloLens, (2) habituation effects to wearing the HoloLens by comparing FOG while walking with HoloLens over sessions, and (3) the potential immediate effect of Holocue on FOG by comparing walking with HoloLens with and without Holocue. Wearing the HoloLens (without Holocue) did significantly increase the number and duration of FOG episodes, but this unfamiliarity effect disappeared with habituation over sessions. This not only emphasizes the need for sufficient habituation to unfamiliar devices, but also testifies to the need for research designs with appropriate control conditions when examining effects of unfamiliar wearable cueing devices. Holocue had overall no immediate effect on FOG, although objective and subjective benefits were observed for some individuals, most notably those with long and/or many FOG episodes. Our participants raised valuable opportunities to improve Holocue and confirmed our assumptions about current and anticipated future design choices, which supports ongoing Holocue development for and with end users. |
| first_indexed | 2024-04-11T20:43:23Z |
| format | Article |
| id | doaj.art-64fc77180c754925be2245ba74fbd340 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-11T20:43:23Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-64fc77180c754925be2245ba74fbd3402022-12-22T04:04:07ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-01-011210.3389/fneur.2021.628388628388Holocue: A Wearable Holographic Cueing Application for Alleviating Freezing of Gait in Parkinson's DiseaseDaphne J. Geerse0Daphne J. Geerse1Bert Coolen2Jacobus J. van Hilten3Melvyn Roerdink4Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, NetherlandsDepartment of Neurology, Leiden University Medical Center, Leiden, NetherlandsDepartment of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, NetherlandsDepartment of Neurology, Leiden University Medical Center, Leiden, NetherlandsDepartment of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, NetherlandsExternal visual cueing is a well-known means to target freezing of gait (FOG) in Parkinson's disease patients. Holocue is a wearable visual cueing application that allows the HoloLens 1 mixed-reality headset to present on-demand patient-tailored action-relevant 2D and 3D holographic visual cues in free-living environments. The aim of this study involving 24 Parkinson's disease patients with dopaminergic “ON state” FOG was two-fold. First, to explore unfamiliarity and habituation effects associated with wearing the HoloLens on FOG. Second, to evaluate the potential immediate effect of Holocue on alleviating FOG in the home environment. Three sessions were conducted to examine (1) the effect of wearing the unfamiliar HoloLens on FOG by comparing walking with and without the HoloLens, (2) habituation effects to wearing the HoloLens by comparing FOG while walking with HoloLens over sessions, and (3) the potential immediate effect of Holocue on FOG by comparing walking with HoloLens with and without Holocue. Wearing the HoloLens (without Holocue) did significantly increase the number and duration of FOG episodes, but this unfamiliarity effect disappeared with habituation over sessions. This not only emphasizes the need for sufficient habituation to unfamiliar devices, but also testifies to the need for research designs with appropriate control conditions when examining effects of unfamiliar wearable cueing devices. Holocue had overall no immediate effect on FOG, although objective and subjective benefits were observed for some individuals, most notably those with long and/or many FOG episodes. Our participants raised valuable opportunities to improve Holocue and confirmed our assumptions about current and anticipated future design choices, which supports ongoing Holocue development for and with end users.https://www.frontiersin.org/articles/10.3389/fneur.2021.628388/fullfreezing of gaitParkinson's diseaseholographic visual cuesunfamiliarity effecthabituationimmediate effect |
| spellingShingle | Daphne J. Geerse Daphne J. Geerse Bert Coolen Jacobus J. van Hilten Melvyn Roerdink Holocue: A Wearable Holographic Cueing Application for Alleviating Freezing of Gait in Parkinson's Disease Frontiers in Neurology freezing of gait Parkinson's disease holographic visual cues unfamiliarity effect habituation immediate effect |
| title | Holocue: A Wearable Holographic Cueing Application for Alleviating Freezing of Gait in Parkinson's Disease |
| title_full | Holocue: A Wearable Holographic Cueing Application for Alleviating Freezing of Gait in Parkinson's Disease |
| title_fullStr | Holocue: A Wearable Holographic Cueing Application for Alleviating Freezing of Gait in Parkinson's Disease |
| title_full_unstemmed | Holocue: A Wearable Holographic Cueing Application for Alleviating Freezing of Gait in Parkinson's Disease |
| title_short | Holocue: A Wearable Holographic Cueing Application for Alleviating Freezing of Gait in Parkinson's Disease |
| title_sort | holocue a wearable holographic cueing application for alleviating freezing of gait in parkinson s disease |
| topic | freezing of gait Parkinson's disease holographic visual cues unfamiliarity effect habituation immediate effect |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2021.628388/full |
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