Timing of the reticular lamina and basilar membrane vibration in living gerbil cochleae
Auditory sensory outer hair cells are thought to amplify sound-induced basilar membrane vibration through a feedback mechanism to enhance hearing sensitivity. For optimal amplification, the outer hair cell-generated force must act on the basilar membrane at an appropriate time at every cycle. Howeve...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2018-09-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/37625 |
| _version_ | 1811235921985536000 |
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| author | Wenxuan He David Kemp Tianying Ren |
| author_facet | Wenxuan He David Kemp Tianying Ren |
| author_sort | Wenxuan He |
| collection | DOAJ |
| description | Auditory sensory outer hair cells are thought to amplify sound-induced basilar membrane vibration through a feedback mechanism to enhance hearing sensitivity. For optimal amplification, the outer hair cell-generated force must act on the basilar membrane at an appropriate time at every cycle. However, the temporal relationship between the outer hair cell-driven reticular lamina vibration and the basilar membrane vibration remains unclear. By measuring sub-nanometer vibrations directly from outer hair cells using a custom-built heterodyne low-coherence interferometer, we demonstrate in living gerbil cochleae that the reticular lamina vibration occurs after, not before, the basilar membrane vibration. Both tone- and click-induced responses indicate that the reticular lamina and basilar membrane vibrate in opposite directions at the cochlear base and they oscillate in phase near the best-frequency location. Our results suggest that outer hair cells enhance hearing sensitivity through a global hydromechanical mechanism, rather than through a local mechanical feedback as commonly supposed. |
| first_indexed | 2024-04-12T12:00:21Z |
| format | Article |
| id | doaj.art-64fd67cb6e774374a4b9eb87bdcc37e5 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T12:00:21Z |
| publishDate | 2018-09-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-64fd67cb6e774374a4b9eb87bdcc37e52022-12-22T03:33:52ZengeLife Sciences Publications LtdeLife2050-084X2018-09-01710.7554/eLife.37625Timing of the reticular lamina and basilar membrane vibration in living gerbil cochleaeWenxuan He0David Kemp1Tianying Ren2https://orcid.org/0000-0002-2533-7203Oregon Hearing Research Center, Department of Otolaryngology, Oregon Health & Science University, Portland, United StatesUniversity College London Ear Institute, University College London, London, United KingdomOregon Hearing Research Center, Department of Otolaryngology, Oregon Health & Science University, Portland, United StatesAuditory sensory outer hair cells are thought to amplify sound-induced basilar membrane vibration through a feedback mechanism to enhance hearing sensitivity. For optimal amplification, the outer hair cell-generated force must act on the basilar membrane at an appropriate time at every cycle. However, the temporal relationship between the outer hair cell-driven reticular lamina vibration and the basilar membrane vibration remains unclear. By measuring sub-nanometer vibrations directly from outer hair cells using a custom-built heterodyne low-coherence interferometer, we demonstrate in living gerbil cochleae that the reticular lamina vibration occurs after, not before, the basilar membrane vibration. Both tone- and click-induced responses indicate that the reticular lamina and basilar membrane vibrate in opposite directions at the cochlear base and they oscillate in phase near the best-frequency location. Our results suggest that outer hair cells enhance hearing sensitivity through a global hydromechanical mechanism, rather than through a local mechanical feedback as commonly supposed.https://elifesciences.org/articles/37625cochleacochlear amplifierouter hair cellslow-coherence interferometerreticular laminabasilar membrane |
| spellingShingle | Wenxuan He David Kemp Tianying Ren Timing of the reticular lamina and basilar membrane vibration in living gerbil cochleae eLife cochlea cochlear amplifier outer hair cells low-coherence interferometer reticular lamina basilar membrane |
| title | Timing of the reticular lamina and basilar membrane vibration in living gerbil cochleae |
| title_full | Timing of the reticular lamina and basilar membrane vibration in living gerbil cochleae |
| title_fullStr | Timing of the reticular lamina and basilar membrane vibration in living gerbil cochleae |
| title_full_unstemmed | Timing of the reticular lamina and basilar membrane vibration in living gerbil cochleae |
| title_short | Timing of the reticular lamina and basilar membrane vibration in living gerbil cochleae |
| title_sort | timing of the reticular lamina and basilar membrane vibration in living gerbil cochleae |
| topic | cochlea cochlear amplifier outer hair cells low-coherence interferometer reticular lamina basilar membrane |
| url | https://elifesciences.org/articles/37625 |
| work_keys_str_mv | AT wenxuanhe timingofthereticularlaminaandbasilarmembranevibrationinlivinggerbilcochleae AT davidkemp timingofthereticularlaminaandbasilarmembranevibrationinlivinggerbilcochleae AT tianyingren timingofthereticularlaminaandbasilarmembranevibrationinlivinggerbilcochleae |