Modular Organization of Signal Transmission in Primate Somatosensory Cortex
Axonal patches are known as the major sites of synaptic connections in the cerebral cortex of higher order mammals. However, the functional role of these patches is highly debated. Patches are formed by populations of nearby neurons in a topographic manner and are recognized as the termination field...
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Neuroanatomy |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnana.2022.915238/full |
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| author | Yaqub Mir Yaqub Mir László Zalányi Emese Pálfi Mária Ashaber Anna W. Roe Anna W. Roe Anna W. Roe Robert M. Friedman László Négyessy |
| author_facet | Yaqub Mir Yaqub Mir László Zalányi Emese Pálfi Mária Ashaber Anna W. Roe Anna W. Roe Anna W. Roe Robert M. Friedman László Négyessy |
| author_sort | Yaqub Mir |
| collection | DOAJ |
| description | Axonal patches are known as the major sites of synaptic connections in the cerebral cortex of higher order mammals. However, the functional role of these patches is highly debated. Patches are formed by populations of nearby neurons in a topographic manner and are recognized as the termination fields of long-distance lateral connections within and between cortical areas. In addition, axons form numerous boutons that lie outside the patches, whose function is also unknown. To better understand the functional roles of these two distinct populations of boutons, we compared individual and collective morphological features of axons within and outside the patches of intra-areal, feedforward, and feedback pathways by way of tract tracing in the somatosensory cortex of New World monkeys. We found that, with the exception of tortuosity, which is an invariant property, bouton spacing and axonal convergence properties differ significantly between axons within patch and no-patch domains. Principal component analyses corroborated the clustering of axons according to patch formation without any additional effect by the type of pathway or laminar distribution. Stepwise logistic regression identified convergence and bouton density as the best predictors of patch formation. These findings support that patches are specific sites of axonal convergence that promote the synchronous activity of neuronal populations. On the other hand, no-patch domains could form a neuroanatomical substrate to diversify the responses of cortical neurons. |
| first_indexed | 2024-12-11T03:51:55Z |
| format | Article |
| id | doaj.art-64fdbf66c94d4f7da1c7bc4e13d0178b |
| institution | Directory Open Access Journal |
| issn | 1662-5129 |
| language | English |
| last_indexed | 2024-12-11T03:51:55Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroanatomy |
| spelling | doaj.art-64fdbf66c94d4f7da1c7bc4e13d0178b2022-12-22T01:21:53ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292022-07-011610.3389/fnana.2022.915238915238Modular Organization of Signal Transmission in Primate Somatosensory CortexYaqub Mir0Yaqub Mir1László Zalányi2Emese Pálfi3Mária Ashaber4Anna W. Roe5Anna W. Roe6Anna W. Roe7Robert M. Friedman8László Négyessy9Theoretical Neuroscience and Complex Systems Group, Department of Computational Sciences, Wigner Research Centre for Physics, Budapest, HungaryJános Szentágothai Doctoral School of Neurosciences, Semmelweis University, Budapest, HungaryTheoretical Neuroscience and Complex Systems Group, Department of Computational Sciences, Wigner Research Centre for Physics, Budapest, HungaryDepartment of Anatomy, Histology and Embryology, Semmelweis University, Budapest, HungaryCalifornia Institute of Technology, Department of Biology and Biological Engineering, Pasadena, CA, United StatesDivision of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, United StatesInterdisciplinary Institute of Neuroscience and Technology, School of Medicine, Zhejiang University, Hangzhou, ChinaKey Laboratory of Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, ChinaDivision of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, United StatesTheoretical Neuroscience and Complex Systems Group, Department of Computational Sciences, Wigner Research Centre for Physics, Budapest, HungaryAxonal patches are known as the major sites of synaptic connections in the cerebral cortex of higher order mammals. However, the functional role of these patches is highly debated. Patches are formed by populations of nearby neurons in a topographic manner and are recognized as the termination fields of long-distance lateral connections within and between cortical areas. In addition, axons form numerous boutons that lie outside the patches, whose function is also unknown. To better understand the functional roles of these two distinct populations of boutons, we compared individual and collective morphological features of axons within and outside the patches of intra-areal, feedforward, and feedback pathways by way of tract tracing in the somatosensory cortex of New World monkeys. We found that, with the exception of tortuosity, which is an invariant property, bouton spacing and axonal convergence properties differ significantly between axons within patch and no-patch domains. Principal component analyses corroborated the clustering of axons according to patch formation without any additional effect by the type of pathway or laminar distribution. Stepwise logistic regression identified convergence and bouton density as the best predictors of patch formation. These findings support that patches are specific sites of axonal convergence that promote the synchronous activity of neuronal populations. On the other hand, no-patch domains could form a neuroanatomical substrate to diversify the responses of cortical neurons.https://www.frontiersin.org/articles/10.3389/fnana.2022.915238/fullanterograde labelingboutonconvergencemultivariate analysissquirrel monkey |
| spellingShingle | Yaqub Mir Yaqub Mir László Zalányi Emese Pálfi Mária Ashaber Anna W. Roe Anna W. Roe Anna W. Roe Robert M. Friedman László Négyessy Modular Organization of Signal Transmission in Primate Somatosensory Cortex Frontiers in Neuroanatomy anterograde labeling bouton convergence multivariate analysis squirrel monkey |
| title | Modular Organization of Signal Transmission in Primate Somatosensory Cortex |
| title_full | Modular Organization of Signal Transmission in Primate Somatosensory Cortex |
| title_fullStr | Modular Organization of Signal Transmission in Primate Somatosensory Cortex |
| title_full_unstemmed | Modular Organization of Signal Transmission in Primate Somatosensory Cortex |
| title_short | Modular Organization of Signal Transmission in Primate Somatosensory Cortex |
| title_sort | modular organization of signal transmission in primate somatosensory cortex |
| topic | anterograde labeling bouton convergence multivariate analysis squirrel monkey |
| url | https://www.frontiersin.org/articles/10.3389/fnana.2022.915238/full |
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