Sport Performance and Manual Therapies: A Review on the Effects on Mitochondrial, Sarcoplasmatic and Ca<sup>2+</sup> Flux Response
The present narrative review aims to highlight the possible effects manual therapies could have on cells and mitochondria, as these effects could improve athletic performance management. To this aim, this review summarizes the relationship between mechanical stimulation, with a special focus on phys...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Healthcare |
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| Online Access: | https://www.mdpi.com/2227-9032/9/2/181 |
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| author | Alex Regno Attilio Parisi Marco Chiera Nicola Barsotti Claudia Cerulli Elisa Grazioli Alessandra Tamburri Marco Bruscolotti |
| author_facet | Alex Regno Attilio Parisi Marco Chiera Nicola Barsotti Claudia Cerulli Elisa Grazioli Alessandra Tamburri Marco Bruscolotti |
| author_sort | Alex Regno |
| collection | DOAJ |
| description | The present narrative review aims to highlight the possible effects manual therapies could have on cells and mitochondria, as these effects could improve athletic performance management. To this aim, this review summarizes the relationship between mechanical stimulation, with a special focus on physical activity, and cell response based on the most recent mechanobiology findings. Mechanobiology analyzes how cells respond to mechanical stressors coming from the environment. Indeed, endogenous (e.g., blood pressure, heartbeat and gastrointestinal motility) and exogenous (e.g., physical activity and manual therapies) stimuli can induce biochemical and epigenetic modifications that alter protein synthesis with heavy consequences on cell behavior. Mechanical stress can also influence mitochondrial behavior (i.e., biogenesis, autophagy, fusion, fission and energy production), sarcoplasmic response and calcium ion (Ca<sup>2+</sup>) flux. Since manual therapies have been shown to affect the extracellular matrix, which represents a primary source of mechanical stress that may alter both the cytoskeleton and mitochondrial metabolism, it is conceivable manual therapies could also affect cellular and mitochondrial behavior. Lastly, by suggesting possible directions for future laboratory and clinical studies, the authors expect this review to inspire further research on how manual therapies could affect bioenergetic metabolism and, thus, athletic performance. |
| first_indexed | 2024-03-09T05:04:00Z |
| format | Article |
| id | doaj.art-64fe3979a5924c3883562cf83fba3fd6 |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-09T05:04:00Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-64fe3979a5924c3883562cf83fba3fd62023-12-03T12:57:04ZengMDPI AGHealthcare2227-90322021-02-019218110.3390/healthcare9020181Sport Performance and Manual Therapies: A Review on the Effects on Mitochondrial, Sarcoplasmatic and Ca<sup>2+</sup> Flux ResponseAlex Regno0Attilio Parisi1Marco Chiera2Nicola Barsotti3Claudia Cerulli4Elisa Grazioli5Alessandra Tamburri6Marco Bruscolotti7Research Commission on Mind-Body Therapies, Italian Society of Psycho Neuro Endocrino Immunology, 00198 Rome, ItalyDepartment of Movement, Human and Health Science, University of Rome “Foro Italico”, 00135 Rome, ItalyResearch Commission on Mind-Body Therapies, Italian Society of Psycho Neuro Endocrino Immunology, 00198 Rome, ItalyResearch Commission on Mind-Body Therapies, Italian Society of Psycho Neuro Endocrino Immunology, 00198 Rome, ItalyDepartment of Movement, Human and Health Science, University of Rome “Foro Italico”, 00135 Rome, ItalyDepartment of Movement, Human and Health Science, University of Rome “Foro Italico”, 00135 Rome, ItalyResearch Commission on Mind-Body Therapies, Italian Society of Psycho Neuro Endocrino Immunology, 00198 Rome, ItalyResearch Commission on Mind-Body Therapies, Italian Society of Psycho Neuro Endocrino Immunology, 00198 Rome, ItalyThe present narrative review aims to highlight the possible effects manual therapies could have on cells and mitochondria, as these effects could improve athletic performance management. To this aim, this review summarizes the relationship between mechanical stimulation, with a special focus on physical activity, and cell response based on the most recent mechanobiology findings. Mechanobiology analyzes how cells respond to mechanical stressors coming from the environment. Indeed, endogenous (e.g., blood pressure, heartbeat and gastrointestinal motility) and exogenous (e.g., physical activity and manual therapies) stimuli can induce biochemical and epigenetic modifications that alter protein synthesis with heavy consequences on cell behavior. Mechanical stress can also influence mitochondrial behavior (i.e., biogenesis, autophagy, fusion, fission and energy production), sarcoplasmic response and calcium ion (Ca<sup>2+</sup>) flux. Since manual therapies have been shown to affect the extracellular matrix, which represents a primary source of mechanical stress that may alter both the cytoskeleton and mitochondrial metabolism, it is conceivable manual therapies could also affect cellular and mitochondrial behavior. Lastly, by suggesting possible directions for future laboratory and clinical studies, the authors expect this review to inspire further research on how manual therapies could affect bioenergetic metabolism and, thus, athletic performance.https://www.mdpi.com/2227-9032/9/2/181mechanotransductionmitochondriaathletic performancestress responsemanual therapycalcium ions |
| spellingShingle | Alex Regno Attilio Parisi Marco Chiera Nicola Barsotti Claudia Cerulli Elisa Grazioli Alessandra Tamburri Marco Bruscolotti Sport Performance and Manual Therapies: A Review on the Effects on Mitochondrial, Sarcoplasmatic and Ca<sup>2+</sup> Flux Response Healthcare mechanotransduction mitochondria athletic performance stress response manual therapy calcium ions |
| title | Sport Performance and Manual Therapies: A Review on the Effects on Mitochondrial, Sarcoplasmatic and Ca<sup>2+</sup> Flux Response |
| title_full | Sport Performance and Manual Therapies: A Review on the Effects on Mitochondrial, Sarcoplasmatic and Ca<sup>2+</sup> Flux Response |
| title_fullStr | Sport Performance and Manual Therapies: A Review on the Effects on Mitochondrial, Sarcoplasmatic and Ca<sup>2+</sup> Flux Response |
| title_full_unstemmed | Sport Performance and Manual Therapies: A Review on the Effects on Mitochondrial, Sarcoplasmatic and Ca<sup>2+</sup> Flux Response |
| title_short | Sport Performance and Manual Therapies: A Review on the Effects on Mitochondrial, Sarcoplasmatic and Ca<sup>2+</sup> Flux Response |
| title_sort | sport performance and manual therapies a review on the effects on mitochondrial sarcoplasmatic and ca sup 2 sup flux response |
| topic | mechanotransduction mitochondria athletic performance stress response manual therapy calcium ions |
| url | https://www.mdpi.com/2227-9032/9/2/181 |
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