Selective Autophagy and Xenophagy in Infection and Disease
Autophagy, a cellular homeostatic process, which ensures cellular survival under various stress conditions, has catapulted to the forefront of innate defense mechanisms during intracellular infections. The ability of autophagy to tag and target intracellular pathogens toward lysosomal degradation is...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-11-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcell.2018.00147/full |
| _version_ | 1819264309283258368 |
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| author | Vartika Sharma Surbhi Verma Elena Seranova Sovan Sarkar Dhiraj Kumar |
| author_facet | Vartika Sharma Surbhi Verma Elena Seranova Sovan Sarkar Dhiraj Kumar |
| author_sort | Vartika Sharma |
| collection | DOAJ |
| description | Autophagy, a cellular homeostatic process, which ensures cellular survival under various stress conditions, has catapulted to the forefront of innate defense mechanisms during intracellular infections. The ability of autophagy to tag and target intracellular pathogens toward lysosomal degradation is central to this key defense function. However, studies involving the role and regulation of autophagy during intracellular infections largely tend to ignore the housekeeping function of autophagy. A growing number of evidences now suggest that the housekeeping function of autophagy, rather than the direct pathogen degradation function, may play a decisive role to determine the outcome of infection and immunological balance. We discuss herein the studies that establish the homeostatic and anti-inflammatory function of autophagy, as well as role of bacterial effectors in modulating and coopting these functions. Given that the core autophagy machinery remains largely the same across diverse cargos, how selectivity plays out during intracellular infection remains intriguing. We explore here, the contrasting role of autophagy adaptors being both selective as well as pleotropic in functions and discuss whether E3 ligases could bring in the specificity to cargo selectivity. |
| first_indexed | 2024-12-23T20:27:26Z |
| format | Article |
| id | doaj.art-64ff240ccb4741d29ff77c56ca9d13a5 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-23T20:27:26Z |
| publishDate | 2018-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-64ff240ccb4741d29ff77c56ca9d13a52022-12-21T17:32:21ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2018-11-01610.3389/fcell.2018.00147411118Selective Autophagy and Xenophagy in Infection and DiseaseVartika Sharma0Surbhi Verma1Elena Seranova2Sovan Sarkar3Dhiraj Kumar4Cellular Immunology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, IndiaCellular Immunology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, IndiaInstitute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United KingdomInstitute of Cancer and Genomic Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United KingdomCellular Immunology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, IndiaAutophagy, a cellular homeostatic process, which ensures cellular survival under various stress conditions, has catapulted to the forefront of innate defense mechanisms during intracellular infections. The ability of autophagy to tag and target intracellular pathogens toward lysosomal degradation is central to this key defense function. However, studies involving the role and regulation of autophagy during intracellular infections largely tend to ignore the housekeeping function of autophagy. A growing number of evidences now suggest that the housekeeping function of autophagy, rather than the direct pathogen degradation function, may play a decisive role to determine the outcome of infection and immunological balance. We discuss herein the studies that establish the homeostatic and anti-inflammatory function of autophagy, as well as role of bacterial effectors in modulating and coopting these functions. Given that the core autophagy machinery remains largely the same across diverse cargos, how selectivity plays out during intracellular infection remains intriguing. We explore here, the contrasting role of autophagy adaptors being both selective as well as pleotropic in functions and discuss whether E3 ligases could bring in the specificity to cargo selectivity.https://www.frontiersin.org/article/10.3389/fcell.2018.00147/fullxenophagyubiquitinationp62NDP52OPTNTAX1BP1 |
| spellingShingle | Vartika Sharma Surbhi Verma Elena Seranova Sovan Sarkar Dhiraj Kumar Selective Autophagy and Xenophagy in Infection and Disease Frontiers in Cell and Developmental Biology xenophagy ubiquitination p62 NDP52 OPTN TAX1BP1 |
| title | Selective Autophagy and Xenophagy in Infection and Disease |
| title_full | Selective Autophagy and Xenophagy in Infection and Disease |
| title_fullStr | Selective Autophagy and Xenophagy in Infection and Disease |
| title_full_unstemmed | Selective Autophagy and Xenophagy in Infection and Disease |
| title_short | Selective Autophagy and Xenophagy in Infection and Disease |
| title_sort | selective autophagy and xenophagy in infection and disease |
| topic | xenophagy ubiquitination p62 NDP52 OPTN TAX1BP1 |
| url | https://www.frontiersin.org/article/10.3389/fcell.2018.00147/full |
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