E4orf1 as a key modulator in oncogenesis and of metabolism in Adenovirus infection
Human Adenoviruses are a diverse family of viruses that can infect a variety of tissues causing acute or persistent infection. Viruses induce numerous cellular alterations as they hijack cellular functions to promote viral progeny. Recent research has shed light on the functions of viral proteins in...
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Frontiers Media S.A.
2023-06-01
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Online Access: | https://www.frontiersin.org/articles/10.3389/fviro.2023.1195717/full |
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author | Leidy Erandy Hernández-Magaña Alfredo Mosqueda-Gracida Víctor Javier Cruz-Holguín Macario Martínez-Castillo Ezequiel M. Fuentes-Pananá Tomasz Rozmyslowicz Moisés León-Juárez Haruki Arévalo-Romero |
author_facet | Leidy Erandy Hernández-Magaña Alfredo Mosqueda-Gracida Víctor Javier Cruz-Holguín Macario Martínez-Castillo Ezequiel M. Fuentes-Pananá Tomasz Rozmyslowicz Moisés León-Juárez Haruki Arévalo-Romero |
author_sort | Leidy Erandy Hernández-Magaña |
collection | DOAJ |
description | Human Adenoviruses are a diverse family of viruses that can infect a variety of tissues causing acute or persistent infection. Viruses induce numerous cellular alterations as they hijack cellular functions to promote viral progeny. Recent research has shed light on the functions of viral proteins in orchestrating viral production, revealing that many of these functions overlap with oncogenesis or metabolic disruption. Studies of the Adenovirus family (Adenoviridae) have identified oncogenic members, such as Adenovirus (Ad-)2, 5, 9, and 12, and also Ad-36, which is most extensively studied for its ability to induce metabolic alterations. Specifically, Adenoviruses encode a gene product known as early region 4 open reading frame 1 (E4orf1), which has emerged as an oncoprotein and regulator of metabolism depending on the lineage of the infected host cell. This article aims to provide insight into the functions of the viral protein E4orf1 and the overlapping similarities between the oncogenic process and cell metabolism. |
first_indexed | 2024-03-13T05:37:33Z |
format | Article |
id | doaj.art-64fff73233f241e1a063abf7565a2f34 |
institution | Directory Open Access Journal |
issn | 2673-818X |
language | English |
last_indexed | 2024-03-13T05:37:33Z |
publishDate | 2023-06-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Virology |
spelling | doaj.art-64fff73233f241e1a063abf7565a2f342023-06-14T05:36:41ZengFrontiers Media S.A.Frontiers in Virology2673-818X2023-06-01310.3389/fviro.2023.11957171195717E4orf1 as a key modulator in oncogenesis and of metabolism in Adenovirus infectionLeidy Erandy Hernández-Magaña0Alfredo Mosqueda-Gracida1Víctor Javier Cruz-Holguín2Macario Martínez-Castillo3Ezequiel M. Fuentes-Pananá4Tomasz Rozmyslowicz5Moisés León-Juárez6Haruki Arévalo-Romero7Laboratorio de Inmunología y Microbiología Molecular, División Académica Multidisciplinaria de Jalpa de Méndez, Departamento de Genómica, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, MexicoLaboratorio de Inmunología y Microbiología Molecular, División Académica Multidisciplinaria de Jalpa de Méndez, Departamento de Genómica, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, MexicoLaboratorio de Virología Perinatal, Departamento de Inmunobioquímica, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Ciudad de México, MexicoSección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México, MexicoUnidad de Investigación en Virología y Cáncer, Hospital Infantil de México Federico Gómez, Ciudad de México, MexicoDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesLaboratorio de Virología Perinatal, Departamento de Inmunobioquímica, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Ciudad de México, MexicoLaboratorio de Inmunología y Microbiología Molecular, División Académica Multidisciplinaria de Jalpa de Méndez, Departamento de Genómica, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, MexicoHuman Adenoviruses are a diverse family of viruses that can infect a variety of tissues causing acute or persistent infection. Viruses induce numerous cellular alterations as they hijack cellular functions to promote viral progeny. Recent research has shed light on the functions of viral proteins in orchestrating viral production, revealing that many of these functions overlap with oncogenesis or metabolic disruption. Studies of the Adenovirus family (Adenoviridae) have identified oncogenic members, such as Adenovirus (Ad-)2, 5, 9, and 12, and also Ad-36, which is most extensively studied for its ability to induce metabolic alterations. Specifically, Adenoviruses encode a gene product known as early region 4 open reading frame 1 (E4orf1), which has emerged as an oncoprotein and regulator of metabolism depending on the lineage of the infected host cell. This article aims to provide insight into the functions of the viral protein E4orf1 and the overlapping similarities between the oncogenic process and cell metabolism.https://www.frontiersin.org/articles/10.3389/fviro.2023.1195717/fullAdenovirus-36adipocytesoncogenesisE4orf1metabolism |
spellingShingle | Leidy Erandy Hernández-Magaña Alfredo Mosqueda-Gracida Víctor Javier Cruz-Holguín Macario Martínez-Castillo Ezequiel M. Fuentes-Pananá Tomasz Rozmyslowicz Moisés León-Juárez Haruki Arévalo-Romero E4orf1 as a key modulator in oncogenesis and of metabolism in Adenovirus infection Frontiers in Virology Adenovirus-36 adipocytes oncogenesis E4orf1 metabolism |
title | E4orf1 as a key modulator in oncogenesis and of metabolism in Adenovirus infection |
title_full | E4orf1 as a key modulator in oncogenesis and of metabolism in Adenovirus infection |
title_fullStr | E4orf1 as a key modulator in oncogenesis and of metabolism in Adenovirus infection |
title_full_unstemmed | E4orf1 as a key modulator in oncogenesis and of metabolism in Adenovirus infection |
title_short | E4orf1 as a key modulator in oncogenesis and of metabolism in Adenovirus infection |
title_sort | e4orf1 as a key modulator in oncogenesis and of metabolism in adenovirus infection |
topic | Adenovirus-36 adipocytes oncogenesis E4orf1 metabolism |
url | https://www.frontiersin.org/articles/10.3389/fviro.2023.1195717/full |
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