Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain

Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain

Abstract Background Leucine rich repeat kinase 2 (LRRK2) and SNCA are genetically linked to late-onset Parkinson’s disease (PD). Aggregated α-synuclein pathologically defines PD. Recent studies identified elevated LRRK2 expression in pro-inflammatory CD16+ monocytes in idiopathic PD, as well as incr...

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Main Authors: Enquan Xu, Ravindra Boddu, Hisham A. Abdelmotilib, Arpine Sokratian, Kaela Kelly, Zhiyong Liu, Nicole Bryant, Sidhanth Chandra, Samantha M. Carlisle, Elliot J. Lefkowitz, Ashley S. Harms, Etty N. Benveniste, Talene A. Yacoubian, Laura A. Volpicelli-Daley, David G. Standaert, Andrew B. West
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Molecular Neurodegeneration
Subjects:
SNCA
PARK8
Monocyte extravasation
Neurodegeneration
Online Access:https://doi.org/10.1186/s13024-021-00509-5

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