Incidence of antibiotics resistance among uropathogens in Omani children presenting with a single episode of urinary tract infection
Summary: Urinary tract infection (UTI) is one of the most common community-acquired infections. Different organisms can be the cause of UTI in children, with resistance to antibiotics becoming a significant problem in the choice of treatment. Worldwide studies have documented the prevalence of uropa...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-09-01
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| Series: | Journal of Infection and Public Health |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S187603411500012X |
| _version_ | 1811194911540641792 |
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| author | Sharef W. Sharef Mohamed El-Naggari Dana Al-Nabhani Ali Al Sawai Zakaria Al Muharrmi Ibtisam Elnour |
| author_facet | Sharef W. Sharef Mohamed El-Naggari Dana Al-Nabhani Ali Al Sawai Zakaria Al Muharrmi Ibtisam Elnour |
| author_sort | Sharef W. Sharef |
| collection | DOAJ |
| description | Summary: Urinary tract infection (UTI) is one of the most common community-acquired infections. Different organisms can be the cause of UTI in children, with resistance to antibiotics becoming a significant problem in the choice of treatment. Worldwide studies have documented the prevalence of uropathogens in different countries. However, there is no previous study documenting the incidence of different uropathogens in Oman. We aim to report the most common uropathogens and their antibiotic sensitivity patterns in children presenting with documented, single episode UTI at a tertiary hospital in Oman. A retrospective analysis of all Omani children below 14 years who presented with a case of first documented UTI to SQUH between September 2008 and August 2012 was conducted. Data were obtained from the patients’ electronic records in the hospital information system. Data were then analyzed using SSPS (Statistical Package for Social Sciences program, Version 20, IBM, Chicago, IL, USA). In the retrospective review of all urine cultures, 438 positive urine cultures were identified. Out of those, 208 (47.5%) belonged to children with their first episode of UTI. Thirty-three patients were excluded and 75 patients were included in the final analysis. Escherichia coli was the most frequently encountered uropathogen in our cohort (69%), followed by Klebsiella pneumoniae infection (17%). Nearly half (46.6%) of these two common organism were resistant to Cotrimoxazole, while 31% of them were resistant to Augmentin. Twenty-four percent of the E. coli and K. pneumoniae strains were resistant to Cefuroxime, and only 10% were resistant to nitrofurantoin. Both Augmentin and Cotrimoxazole should not be the first line antibiotics to treat UTI. Keywords: Urinary tract infection, Uropathogens, Sultan Qaboos University Hospital, Oman |
| first_indexed | 2024-04-12T00:35:11Z |
| format | Article |
| id | doaj.art-6505a2e732f24b37a9a8f13f36a9eb00 |
| institution | Directory Open Access Journal |
| issn | 1876-0341 |
| language | English |
| last_indexed | 2024-04-12T00:35:11Z |
| publishDate | 2015-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj.art-6505a2e732f24b37a9a8f13f36a9eb002022-12-22T03:55:11ZengElsevierJournal of Infection and Public Health1876-03412015-09-0185458465Incidence of antibiotics resistance among uropathogens in Omani children presenting with a single episode of urinary tract infectionSharef W. Sharef0Mohamed El-Naggari1Dana Al-Nabhani2Ali Al Sawai3Zakaria Al Muharrmi4Ibtisam Elnour5Sultan Qaboos University Hospital, Child Health Department, Muscat, OmanSultan Qaboos University Hospital, Child Health Department, Muscat, Oman; Corresponding author at: Sultan Qaboos University, P.O. 38, Zip Code 123, Alkoud, Muscat, Oman. Tel.: +968 98178236; fax: +968 24144105.Sultan Qaboos University Hospital, Child Health Department, Muscat, OmanSultan Qaboos University Hospital, Child Health Department, Muscat, OmanSultan Qaboos University Hospital, Microbiology Department, Muscat, OmanSultan Qaboos University Hospital, Child Health Department, Muscat, OmanSummary: Urinary tract infection (UTI) is one of the most common community-acquired infections. Different organisms can be the cause of UTI in children, with resistance to antibiotics becoming a significant problem in the choice of treatment. Worldwide studies have documented the prevalence of uropathogens in different countries. However, there is no previous study documenting the incidence of different uropathogens in Oman. We aim to report the most common uropathogens and their antibiotic sensitivity patterns in children presenting with documented, single episode UTI at a tertiary hospital in Oman. A retrospective analysis of all Omani children below 14 years who presented with a case of first documented UTI to SQUH between September 2008 and August 2012 was conducted. Data were obtained from the patients’ electronic records in the hospital information system. Data were then analyzed using SSPS (Statistical Package for Social Sciences program, Version 20, IBM, Chicago, IL, USA). In the retrospective review of all urine cultures, 438 positive urine cultures were identified. Out of those, 208 (47.5%) belonged to children with their first episode of UTI. Thirty-three patients were excluded and 75 patients were included in the final analysis. Escherichia coli was the most frequently encountered uropathogen in our cohort (69%), followed by Klebsiella pneumoniae infection (17%). Nearly half (46.6%) of these two common organism were resistant to Cotrimoxazole, while 31% of them were resistant to Augmentin. Twenty-four percent of the E. coli and K. pneumoniae strains were resistant to Cefuroxime, and only 10% were resistant to nitrofurantoin. Both Augmentin and Cotrimoxazole should not be the first line antibiotics to treat UTI. Keywords: Urinary tract infection, Uropathogens, Sultan Qaboos University Hospital, Omanhttp://www.sciencedirect.com/science/article/pii/S187603411500012X |
| spellingShingle | Sharef W. Sharef Mohamed El-Naggari Dana Al-Nabhani Ali Al Sawai Zakaria Al Muharrmi Ibtisam Elnour Incidence of antibiotics resistance among uropathogens in Omani children presenting with a single episode of urinary tract infection Journal of Infection and Public Health |
| title | Incidence of antibiotics resistance among uropathogens in Omani children presenting with a single episode of urinary tract infection |
| title_full | Incidence of antibiotics resistance among uropathogens in Omani children presenting with a single episode of urinary tract infection |
| title_fullStr | Incidence of antibiotics resistance among uropathogens in Omani children presenting with a single episode of urinary tract infection |
| title_full_unstemmed | Incidence of antibiotics resistance among uropathogens in Omani children presenting with a single episode of urinary tract infection |
| title_short | Incidence of antibiotics resistance among uropathogens in Omani children presenting with a single episode of urinary tract infection |
| title_sort | incidence of antibiotics resistance among uropathogens in omani children presenting with a single episode of urinary tract infection |
| url | http://www.sciencedirect.com/science/article/pii/S187603411500012X |
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