Signals and Cells Involved in Regulating Liver Regeneration
Liver regeneration is a complex phenomenon aimed at maintaining a constant liver mass in the event of injury resulting in loss of hepatic parenchyma. Partial hepatectomy is followed by a series of events involving multiple signaling pathways controlled by mitogenic growth factors (HGF, EGF) and thei...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-12-01
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| Series: | Cells |
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| Online Access: | http://www.mdpi.com/2073-4409/1/4/1261 |
| _version_ | 1797762655350423552 |
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| author | Liang-I. Kang Wendy M. Mars George K. Michalopoulos |
| author_facet | Liang-I. Kang Wendy M. Mars George K. Michalopoulos |
| author_sort | Liang-I. Kang |
| collection | DOAJ |
| description | Liver regeneration is a complex phenomenon aimed at maintaining a constant liver mass in the event of injury resulting in loss of hepatic parenchyma. Partial hepatectomy is followed by a series of events involving multiple signaling pathways controlled by mitogenic growth factors (HGF, EGF) and their receptors (MET and EGFR). In addition multiple cytokines and other signaling molecules contribute to the orchestration of a signal which drives hepatocytes into DNA synthesis. The other cell types of the liver receive and transmit to hepatocytes complex signals so that, in the end of the regenerative process, complete hepatic tissue is assembled and regeneration is terminated at the proper time and at the right liver size. If hepatocytes fail to participate in this process, the biliary compartment is mobilized to generate populations of progenitor cells which transdifferentiate into hepatocytes and restore liver size. |
| first_indexed | 2024-03-12T19:30:33Z |
| format | Article |
| id | doaj.art-6507efc554fa4b3e959f8703a41c328f |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T19:30:33Z |
| publishDate | 2012-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-6507efc554fa4b3e959f8703a41c328f2023-08-02T04:33:57ZengMDPI AGCells2073-44092012-12-01141261129210.3390/cells1041261Signals and Cells Involved in Regulating Liver RegenerationLiang-I. KangWendy M. MarsGeorge K. MichalopoulosLiver regeneration is a complex phenomenon aimed at maintaining a constant liver mass in the event of injury resulting in loss of hepatic parenchyma. Partial hepatectomy is followed by a series of events involving multiple signaling pathways controlled by mitogenic growth factors (HGF, EGF) and their receptors (MET and EGFR). In addition multiple cytokines and other signaling molecules contribute to the orchestration of a signal which drives hepatocytes into DNA synthesis. The other cell types of the liver receive and transmit to hepatocytes complex signals so that, in the end of the regenerative process, complete hepatic tissue is assembled and regeneration is terminated at the proper time and at the right liver size. If hepatocytes fail to participate in this process, the biliary compartment is mobilized to generate populations of progenitor cells which transdifferentiate into hepatocytes and restore liver size.http://www.mdpi.com/2073-4409/1/4/1261liver regenerationhepatocytehepatocyte growth factorepidermal growth factorpartial hepatectomytransdifferentitationoval cell |
| spellingShingle | Liang-I. Kang Wendy M. Mars George K. Michalopoulos Signals and Cells Involved in Regulating Liver Regeneration Cells liver regeneration hepatocyte hepatocyte growth factor epidermal growth factor partial hepatectomy transdifferentitation oval cell |
| title | Signals and Cells Involved in Regulating Liver Regeneration |
| title_full | Signals and Cells Involved in Regulating Liver Regeneration |
| title_fullStr | Signals and Cells Involved in Regulating Liver Regeneration |
| title_full_unstemmed | Signals and Cells Involved in Regulating Liver Regeneration |
| title_short | Signals and Cells Involved in Regulating Liver Regeneration |
| title_sort | signals and cells involved in regulating liver regeneration |
| topic | liver regeneration hepatocyte hepatocyte growth factor epidermal growth factor partial hepatectomy transdifferentitation oval cell |
| url | http://www.mdpi.com/2073-4409/1/4/1261 |
| work_keys_str_mv | AT liangikang signalsandcellsinvolvedinregulatingliverregeneration AT wendymmars signalsandcellsinvolvedinregulatingliverregeneration AT georgekmichalopoulos signalsandcellsinvolvedinregulatingliverregeneration |