Lipids and lipoxidation in human brain aging. Mitochondrial ATP-synthase as a key lipoxidation target
The human brain is a target of the aging process like other cell systems of the human body. Specific regions of the human brain exhibit differential vulnerabilities to the aging process. Yet the underlying mechanisms that sustain the preservation or deterioration of neurons and cerebral functions ar...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-05-01
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| Series: | Redox Biology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231718309613 |
| _version_ | 1818553286656000000 |
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| author | Mariona Jové Irene Pradas Mayelin Dominguez-Gonzalez Isidro Ferrer Reinald Pamplona |
| author_facet | Mariona Jové Irene Pradas Mayelin Dominguez-Gonzalez Isidro Ferrer Reinald Pamplona |
| author_sort | Mariona Jové |
| collection | DOAJ |
| description | The human brain is a target of the aging process like other cell systems of the human body. Specific regions of the human brain exhibit differential vulnerabilities to the aging process. Yet the underlying mechanisms that sustain the preservation or deterioration of neurons and cerebral functions are unknown. In this review, we focus attention on the role of lipids and the importance of the cross-regionally different vulnerabilities in human brain aging. In particular, we first consider a brief approach to the lipidomics of human brain, the relationship between lipids and lipoxidative damage, the role of lipids in human brain aging, and the specific targets of lipoxidative damage in human brain and during aging. It is proposed that the restricted set of modified proteins and the functional categories involved may be considered putative collaborative factors contributing to neuronal aging, and that mitochondrial ATP synthase is a key lipoxidative target in human brain aging. Keywords: Advanced lipoxidation end products, Aging, Antioxidants, Cytoskeleton, Energy metabolism, Lipidomics, Neurotransmission, Oxidative stress, Proteostasis, Reactive carbonyl species, Redox proteomics |
| first_indexed | 2024-12-12T09:23:55Z |
| format | Article |
| id | doaj.art-6509585f81df43069420651459b69d52 |
| institution | Directory Open Access Journal |
| issn | 2213-2317 |
| language | English |
| last_indexed | 2024-12-12T09:23:55Z |
| publishDate | 2019-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Redox Biology |
| spelling | doaj.art-6509585f81df43069420651459b69d522022-12-22T00:29:05ZengElsevierRedox Biology2213-23172019-05-0123Lipids and lipoxidation in human brain aging. Mitochondrial ATP-synthase as a key lipoxidation targetMariona Jové0Irene Pradas1Mayelin Dominguez-Gonzalez2Isidro Ferrer3Reinald Pamplona4Department of Experimental Medicine, University of Lleida—Institute for Research in Biomedicine of Lleida (UdL-IRBLleida), Lleida, SpainDepartment of Experimental Medicine, University of Lleida—Institute for Research in Biomedicine of Lleida (UdL-IRBLleida), Lleida, SpainDepartment of Pathology and Experimental Therapeutics, University of Barcelona; Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona, SpainDepartment of Pathology and Experimental Therapeutics, University of Barcelona; Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona, Spain; Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED), ISCIII, SpainDepartment of Experimental Medicine, University of Lleida—Institute for Research in Biomedicine of Lleida (UdL-IRBLleida), Lleida, Spain; Correspondence to: Departament de Medicina Experimental, Universitat de Lleida—Institut de Recerca Biomedica de Lleida (IRBLleida), Edifici Biomedicina 1, Av. Alcalde Rovira Roure-80, Lleida 25198, Catalunya, Spain.The human brain is a target of the aging process like other cell systems of the human body. Specific regions of the human brain exhibit differential vulnerabilities to the aging process. Yet the underlying mechanisms that sustain the preservation or deterioration of neurons and cerebral functions are unknown. In this review, we focus attention on the role of lipids and the importance of the cross-regionally different vulnerabilities in human brain aging. In particular, we first consider a brief approach to the lipidomics of human brain, the relationship between lipids and lipoxidative damage, the role of lipids in human brain aging, and the specific targets of lipoxidative damage in human brain and during aging. It is proposed that the restricted set of modified proteins and the functional categories involved may be considered putative collaborative factors contributing to neuronal aging, and that mitochondrial ATP synthase is a key lipoxidative target in human brain aging. Keywords: Advanced lipoxidation end products, Aging, Antioxidants, Cytoskeleton, Energy metabolism, Lipidomics, Neurotransmission, Oxidative stress, Proteostasis, Reactive carbonyl species, Redox proteomicshttp://www.sciencedirect.com/science/article/pii/S2213231718309613 |
| spellingShingle | Mariona Jové Irene Pradas Mayelin Dominguez-Gonzalez Isidro Ferrer Reinald Pamplona Lipids and lipoxidation in human brain aging. Mitochondrial ATP-synthase as a key lipoxidation target Redox Biology |
| title | Lipids and lipoxidation in human brain aging. Mitochondrial ATP-synthase as a key lipoxidation target |
| title_full | Lipids and lipoxidation in human brain aging. Mitochondrial ATP-synthase as a key lipoxidation target |
| title_fullStr | Lipids and lipoxidation in human brain aging. Mitochondrial ATP-synthase as a key lipoxidation target |
| title_full_unstemmed | Lipids and lipoxidation in human brain aging. Mitochondrial ATP-synthase as a key lipoxidation target |
| title_short | Lipids and lipoxidation in human brain aging. Mitochondrial ATP-synthase as a key lipoxidation target |
| title_sort | lipids and lipoxidation in human brain aging mitochondrial atp synthase as a key lipoxidation target |
| url | http://www.sciencedirect.com/science/article/pii/S2213231718309613 |
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