TRIM24 is an insulin-responsive regulator of P-bodies
Insulin promotes hepatic lipogenesis, though underlying regulation remains unclear. Here the authors show that insulin translocates TRIM24 from the nucleus into cytosolic P-bodies to stabilise hepatic Pparγ mRNA, and that inactivation of TRIM24 promotes Pparγ degradation and alleviates hepatosteatos...
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Bibliographic Details
| Main Authors: |
Wen Wei,
Qiaoli Chen,
Minjun Liu,
Yang Sheng,
Qian OuYang,
Weikuan Feng,
Xinyu Yang,
Longfei Ding,
Shu Su,
Jingzi Zhang,
Lei Fang,
Antonio Vidal-Puig,
Hong-Yu Wang,
Shuai Chen |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-07-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-31735-0
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