Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme

Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme

Abstract Background Mice carrying targeted mutations are important for investigating gene function and the role of genes in disease, but off-target mutagenic effects associated with the processes of generating targeted alleles, for instance using Crispr, and culturing embryonic stem cells, offer opp...

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Bibliographic Details
Main Authors: Morag A. Lewis, Neil J. Ingham, Jing Chen, Selina Pearson, Francesca Di Domenico, Sohinder Rekhi, Rochelle Allen, Matthew Drake, Annelore Willaert, Victoria Rook, Johanna Pass, Thomas Keane, David J. Adams, Abigail S. Tucker, Jacqueline K. White, Karen P. Steel
Format: Article
Language:English
Published: BMC 2022-03-01
Series:BMC Biology
Subjects:
Spontaneous mutations
Large-scale mutagenesis programme
Deafness
Progressive hearing loss
Non-segregating phenotypes
Online Access:https://doi.org/10.1186/s12915-022-01257-8

Internet

https://doi.org/10.1186/s12915-022-01257-8

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