Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme
Abstract Background Mice carrying targeted mutations are important for investigating gene function and the role of genes in disease, but off-target mutagenic effects associated with the processes of generating targeted alleles, for instance using Crispr, and culturing embryonic stem cells, offer opp...
Main Authors: | Morag A. Lewis, Neil J. Ingham, Jing Chen, Selina Pearson, Francesca Di Domenico, Sohinder Rekhi, Rochelle Allen, Matthew Drake, Annelore Willaert, Victoria Rook, Johanna Pass, Thomas Keane, David J. Adams, Abigail S. Tucker, Jacqueline K. White, Karen P. Steel |
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Format: | Article |
Language: | English |
Published: |
BMC
2022-03-01
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Series: | BMC Biology |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12915-022-01257-8 |
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