KEA-1010, a ketamine ester analogue, retains analgesic and sedative potency but is devoid of Psychomimetic effects

KEA-1010, a ketamine ester analogue, retains analgesic and sedative potency but is devoid of Psychomimetic effects

Abstract Background Ketamine, a widely used anaesthetic and analgesic agent, is known to improve the analgesic efficacy of opioids and to attenuate central sensitisation and opioid-induced hyperalgesia. Clinical use is, however, curtailed by unwanted psychomimetic effects thought to be mediated by N...

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Bibliographic Details
Main Authors: Martyn Harvey, Jamie Sleigh, Logan Voss, Mike Bickerdike, Ivaylo Dimitrov, William Denny
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Pharmacology and Toxicology
Subjects:
Ketamine
Analogue
Analgesia
Pain
Online Access:https://doi.org/10.1186/s40360-019-0374-y

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