Low-Level Ionizing Radiation Induces Selective Killing of HIV-1-Infected Cells with Reversal of Cytokine Induction Using mTOR Inhibitors

Low-Level Ionizing Radiation Induces Selective Killing of HIV-1-Infected Cells with Reversal of Cytokine Induction Using mTOR Inhibitors

HIV-1 infects 39.5 million people worldwide, and cART is effective in preventing viral spread by reducing HIV-1 plasma viral loads to undetectable levels. However, viral reservoirs persist by mechanisms, including the inhibition of autophagy by HIV-1 proteins (i.e., Nef and Tat). HIV-1 reservoirs ca...

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Bibliographic Details
Main Authors: Daniel O. Pinto, Catherine DeMarino, Thy T. Vo, Maria Cowen, Yuriy Kim, Michelle L. Pleet, Robert A. Barclay, Nicole Noren Hooten, Michele K. Evans, Alonso Heredia, Elena V. Batrakova, Sergey Iordanskiy, Fatah Kashanchi
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Viruses
Subjects:
HIV-1
autophagy
extracellular vesicles
latency reversal
Ionizing radiation
cell death
Online Access:https://www.mdpi.com/1999-4915/12/8/885

Internet

https://www.mdpi.com/1999-4915/12/8/885

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