Mutations in foregut SOX2+ cells induce efficient proliferation via CXCR2 pathway

Mutations in foregut SOX2+ cells induce efficient proliferation via CXCR2 pathway

Abstract Identification of the precise molecular pathways involved in oncogene-induced transformation may help us gain a better understanding of tumor initiation and promotion. Here, we demonstrate that SOX2+ foregut epithelial cells are prone to oncogenic transformation upon mutagenic insults, such...

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Bibliographic Details
Main Authors: Tomoaki Hishida, Eric Vazquez-Ferrer, Yuriko Hishida-Nozaki, Ignacio Sancho-Martinez, Yuta Takahashi, Fumiyuki Hatanaka, Jun Wu, Alejandro Ocampo, Pradeep Reddy, Min-Zu Wu, Laurie Gerken, Reuben J. Shaw, Concepcion Rodriguez Esteban, Christopher Benner, Hiroshi Nakagawa, Pedro Guillen Garcia, Estrella Nuñez Delicado, Antoni Castells, Josep M. Campistol, Guang-Hui Liu, Juan Carlos Izpisua Belmonte
Format: Article
Language:English
Published: Oxford University Press 2019-04-01
Series:Protein & Cell
Subjects:
Sox2
tumor
CXCR2
stratified epithelia
Online Access:http://link.springer.com/article/10.1007/s13238-019-0630-3

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