The Impact of Gut Microbiota-Derived Metabolites on the Tumor Immune Microenvironment
Prevention of the effectiveness of anti-tumor immune responses is one of the canonical cancer hallmarks. The competition for crucial nutrients within the tumor microenvironment (TME) between cancer cells and immune cells creates a complex interplay characterized by metabolic deprivation. Extensive e...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/5/1588 |
| _version_ | 1797615582973001728 |
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| author | Maik Luu Burkhard Schütz Matthias Lauth Alexander Visekruna |
| author_facet | Maik Luu Burkhard Schütz Matthias Lauth Alexander Visekruna |
| author_sort | Maik Luu |
| collection | DOAJ |
| description | Prevention of the effectiveness of anti-tumor immune responses is one of the canonical cancer hallmarks. The competition for crucial nutrients within the tumor microenvironment (TME) between cancer cells and immune cells creates a complex interplay characterized by metabolic deprivation. Extensive efforts have recently been made to understand better the dynamic interactions between cancer cells and surrounding immune cells. Paradoxically, both cancer cells and activated T cells are metabolically dependent on glycolysis, even in the presence of oxygen, a metabolic process known as the Warburg effect. The intestinal microbial community delivers various types of small molecules that can potentially augment the functional capabilities of the host immune system. Currently, several studies are trying to explore the complex functional relationship between the metabolites secreted by the human microbiome and anti-tumor immunity. Recently, it has been shown that a diverse array of commensal bacteria synthetizes bioactive molecules that enhance the efficacy of cancer immunotherapy, including immune checkpoint inhibitor (ICI) treatment and adoptive cell therapy with chimeric antigen receptor (CAR) T cells. In this review, we highlight the importance of commensal bacteria, particularly of the gut microbiota-derived metabolites that are capable of shaping metabolic, transcriptional and epigenetic processes within the TME in a therapeutically meaningful way. |
| first_indexed | 2024-03-11T07:28:40Z |
| format | Article |
| id | doaj.art-650d799d7c744e54b90cabac083383a5 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T07:28:40Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-650d799d7c744e54b90cabac083383a52023-11-17T07:26:06ZengMDPI AGCancers2072-66942023-03-01155158810.3390/cancers15051588The Impact of Gut Microbiota-Derived Metabolites on the Tumor Immune MicroenvironmentMaik Luu0Burkhard Schütz1Matthias Lauth2Alexander Visekruna3Lehrstuhl für Zelluläre Immuntherapie, Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, 97080 Würzburg, GermanyInstitute of Anatomy and Cell Biology, Philipps-University Marburg, 35037 Marburg, GermanyDepartment of Gastroenterology, Center for Tumor and Immune Biology (ZTI), Philipps-University Marburg, 35043 Marburg, GermanyInstitute for Medical Microbiology and Hygiene, Philipps-University Marburg, 35043 Marburg, GermanyPrevention of the effectiveness of anti-tumor immune responses is one of the canonical cancer hallmarks. The competition for crucial nutrients within the tumor microenvironment (TME) between cancer cells and immune cells creates a complex interplay characterized by metabolic deprivation. Extensive efforts have recently been made to understand better the dynamic interactions between cancer cells and surrounding immune cells. Paradoxically, both cancer cells and activated T cells are metabolically dependent on glycolysis, even in the presence of oxygen, a metabolic process known as the Warburg effect. The intestinal microbial community delivers various types of small molecules that can potentially augment the functional capabilities of the host immune system. Currently, several studies are trying to explore the complex functional relationship between the metabolites secreted by the human microbiome and anti-tumor immunity. Recently, it has been shown that a diverse array of commensal bacteria synthetizes bioactive molecules that enhance the efficacy of cancer immunotherapy, including immune checkpoint inhibitor (ICI) treatment and adoptive cell therapy with chimeric antigen receptor (CAR) T cells. In this review, we highlight the importance of commensal bacteria, particularly of the gut microbiota-derived metabolites that are capable of shaping metabolic, transcriptional and epigenetic processes within the TME in a therapeutically meaningful way.https://www.mdpi.com/2072-6694/15/5/1588tumor microenvironment (TME)commensal bacteriaintratumoral microbiotaoncobiomemicrobiota-derived metabolitescancer immunotherapy |
| spellingShingle | Maik Luu Burkhard Schütz Matthias Lauth Alexander Visekruna The Impact of Gut Microbiota-Derived Metabolites on the Tumor Immune Microenvironment Cancers tumor microenvironment (TME) commensal bacteria intratumoral microbiota oncobiome microbiota-derived metabolites cancer immunotherapy |
| title | The Impact of Gut Microbiota-Derived Metabolites on the Tumor Immune Microenvironment |
| title_full | The Impact of Gut Microbiota-Derived Metabolites on the Tumor Immune Microenvironment |
| title_fullStr | The Impact of Gut Microbiota-Derived Metabolites on the Tumor Immune Microenvironment |
| title_full_unstemmed | The Impact of Gut Microbiota-Derived Metabolites on the Tumor Immune Microenvironment |
| title_short | The Impact of Gut Microbiota-Derived Metabolites on the Tumor Immune Microenvironment |
| title_sort | impact of gut microbiota derived metabolites on the tumor immune microenvironment |
| topic | tumor microenvironment (TME) commensal bacteria intratumoral microbiota oncobiome microbiota-derived metabolites cancer immunotherapy |
| url | https://www.mdpi.com/2072-6694/15/5/1588 |
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