Hybrid polymeric matrices for oral modified release of Desvenlafaxine succinate tablets

Hybrid polymeric matrices for oral modified release of Desvenlafaxine succinate tablets

Purpose: Desvenlafaxine succinate (DSV) is a water soluble anti-depressant drug, which is rapidly absorbed after oral administration exaggerating its side effects. The current work aimed to prepare controllable release DSV matrix to reduce DSV side effects related to its initial burst. Methods: Fift...

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Bibliographic Details
Main Authors: Wael Samy, Ayman Elnoby, Hanan M. El-Gowelli, Nazik Elgindy
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Saudi Pharmaceutical Journal
Subjects:
Desvenlafaxine succinate
Controlled release matrix
Apparent permeability coefficient
Everted sac
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016416301104

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