Association of Surgical Margin Status with Oncologic Outcome in Patients Treated with Breast-Conserving Surgery
We aimed to compare the prognosis of patients with close resection margins after breast-conserving surgery (BCS) with that of patients with negative margins and identified predictors of residual disease. A total of 542 patients with breast cancer who underwent BCS between 2003 and 2019 were selected...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-11-01
|
| Series: | Current Oncology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1718-7729/29/12/726 |
| _version_ | 1797460736361889792 |
|---|---|
| author | Sumin Chae Sun Young Min |
| author_facet | Sumin Chae Sun Young Min |
| author_sort | Sumin Chae |
| collection | DOAJ |
| description | We aimed to compare the prognosis of patients with close resection margins after breast-conserving surgery (BCS) with that of patients with negative margins and identified predictors of residual disease. A total of 542 patients with breast cancer who underwent BCS between 2003 and 2019 were selected and divided into the close margin (114 patients) and negative margin (428 patients) groups. The median follow-up period was 72 (interquartile range, 42–113) months. Most patients received radiation therapy (RTx) and systemic therapy according to their stage and molecular subtype. The 10-year locoregional recurrence-free survival rates of the close and negative margin groups were 88.2% and 95.5%, respectively (<i>p</i> = 0.001). Multivariable analysis showed that adjuvant RTx and margin status after definitive surgery were significantly associated with locoregional recurrence. Of the 57 patients who underwent re-excision, 34 (59.6%) had residual disease. Multivariable analysis revealed that a histological type of positive or close margins and multifocality were independent predictive factors for residual disease. Although the current guidelines suggest that <i>no ink on tumor</i> is an adequate margin after BCS, a close resection margin may be associated with locoregional failure. The treatment strategy for close resection margins after BCS should be based on individual clinicopathological features. |
| first_indexed | 2024-03-09T17:09:17Z |
| format | Article |
| id | doaj.art-65139194ea9b4fcaa505634852993348 |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-09T17:09:17Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-65139194ea9b4fcaa5056348529933482023-11-24T14:12:29ZengMDPI AGCurrent Oncology1198-00521718-77292022-11-0129129271928310.3390/curroncol29120726Association of Surgical Margin Status with Oncologic Outcome in Patients Treated with Breast-Conserving SurgerySumin Chae0Sun Young Min1Department of Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of KoreaDepartment of Surgery, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul 02447, Republic of KoreaWe aimed to compare the prognosis of patients with close resection margins after breast-conserving surgery (BCS) with that of patients with negative margins and identified predictors of residual disease. A total of 542 patients with breast cancer who underwent BCS between 2003 and 2019 were selected and divided into the close margin (114 patients) and negative margin (428 patients) groups. The median follow-up period was 72 (interquartile range, 42–113) months. Most patients received radiation therapy (RTx) and systemic therapy according to their stage and molecular subtype. The 10-year locoregional recurrence-free survival rates of the close and negative margin groups were 88.2% and 95.5%, respectively (<i>p</i> = 0.001). Multivariable analysis showed that adjuvant RTx and margin status after definitive surgery were significantly associated with locoregional recurrence. Of the 57 patients who underwent re-excision, 34 (59.6%) had residual disease. Multivariable analysis revealed that a histological type of positive or close margins and multifocality were independent predictive factors for residual disease. Although the current guidelines suggest that <i>no ink on tumor</i> is an adequate margin after BCS, a close resection margin may be associated with locoregional failure. The treatment strategy for close resection margins after BCS should be based on individual clinicopathological features.https://www.mdpi.com/1718-7729/29/12/726breast-conserving surgeryclose resection marginresidual diseaselocoregional recurrence |
| spellingShingle | Sumin Chae Sun Young Min Association of Surgical Margin Status with Oncologic Outcome in Patients Treated with Breast-Conserving Surgery Current Oncology breast-conserving surgery close resection margin residual disease locoregional recurrence |
| title | Association of Surgical Margin Status with Oncologic Outcome in Patients Treated with Breast-Conserving Surgery |
| title_full | Association of Surgical Margin Status with Oncologic Outcome in Patients Treated with Breast-Conserving Surgery |
| title_fullStr | Association of Surgical Margin Status with Oncologic Outcome in Patients Treated with Breast-Conserving Surgery |
| title_full_unstemmed | Association of Surgical Margin Status with Oncologic Outcome in Patients Treated with Breast-Conserving Surgery |
| title_short | Association of Surgical Margin Status with Oncologic Outcome in Patients Treated with Breast-Conserving Surgery |
| title_sort | association of surgical margin status with oncologic outcome in patients treated with breast conserving surgery |
| topic | breast-conserving surgery close resection margin residual disease locoregional recurrence |
| url | https://www.mdpi.com/1718-7729/29/12/726 |
| work_keys_str_mv | AT suminchae associationofsurgicalmarginstatuswithoncologicoutcomeinpatientstreatedwithbreastconservingsurgery AT sunyoungmin associationofsurgicalmarginstatuswithoncologicoutcomeinpatientstreatedwithbreastconservingsurgery |