Role of the JAK/STAT Pathway in Cervical Cancer: Its Relationship with HPV E6/E7 Oncoproteins
The janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway is associated with the regulation of essential cellular mechanisms, such as proliferation, invasion, survival, inflammation, and immunity. Aberrant JAK/STAT signaling contributes to cancer progression an...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/10/2297 |
| _version_ | 1797550931402817536 |
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| author | Adriana Gutiérrez-Hoya Isabel Soto-Cruz |
| author_facet | Adriana Gutiérrez-Hoya Isabel Soto-Cruz |
| author_sort | Adriana Gutiérrez-Hoya |
| collection | DOAJ |
| description | The janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway is associated with the regulation of essential cellular mechanisms, such as proliferation, invasion, survival, inflammation, and immunity. Aberrant JAK/STAT signaling contributes to cancer progression and metastatic development. STAT proteins play an essential role in the development of cervical cancer, and the inhibition of the JAK/STAT pathway may be essential for enhancing tumor cell death. Persistent activation of different STATs is present in a variety of cancers, including cervical cancer, and their overactivation may be associated with a poor prognosis and poor overall survival. The oncoproteins E6 and E7 play a critical role in the progression of cervical cancer and may mediate the activation of the JAK/STAT pathway. Inhibition of STAT proteins appears to show promise for establishing new targets in cancer treatment. The present review summarizes the knowledge about the participation of the different components of the JAK/STAT pathway and the participation of the human papillomavirus (HPV) associated with the process of cellular malignancy. |
| first_indexed | 2024-03-10T15:36:27Z |
| format | Article |
| id | doaj.art-6513a3e698454060b142cb56743dc76a |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T15:36:27Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-6513a3e698454060b142cb56743dc76a2023-11-20T17:10:36ZengMDPI AGCells2073-44092020-10-01910229710.3390/cells9102297Role of the JAK/STAT Pathway in Cervical Cancer: Its Relationship with HPV E6/E7 OncoproteinsAdriana Gutiérrez-Hoya0Isabel Soto-Cruz1Molecular Oncology Laboratory, Cell Differentiation and Cancer Research Unit, FES Zaragoza, National University of Mexico, Batalla 5 de Mayo s/n Col. Ejército de Oriente, Mexico City 09230, MexicoMolecular Oncology Laboratory, Cell Differentiation and Cancer Research Unit, FES Zaragoza, National University of Mexico, Batalla 5 de Mayo s/n Col. Ejército de Oriente, Mexico City 09230, MexicoThe janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway is associated with the regulation of essential cellular mechanisms, such as proliferation, invasion, survival, inflammation, and immunity. Aberrant JAK/STAT signaling contributes to cancer progression and metastatic development. STAT proteins play an essential role in the development of cervical cancer, and the inhibition of the JAK/STAT pathway may be essential for enhancing tumor cell death. Persistent activation of different STATs is present in a variety of cancers, including cervical cancer, and their overactivation may be associated with a poor prognosis and poor overall survival. The oncoproteins E6 and E7 play a critical role in the progression of cervical cancer and may mediate the activation of the JAK/STAT pathway. Inhibition of STAT proteins appears to show promise for establishing new targets in cancer treatment. The present review summarizes the knowledge about the participation of the different components of the JAK/STAT pathway and the participation of the human papillomavirus (HPV) associated with the process of cellular malignancy.https://www.mdpi.com/2073-4409/9/10/2297signal transducer and activator of transcriptionSTAT inhibitorssignaling pathwaycervical cancerHPV |
| spellingShingle | Adriana Gutiérrez-Hoya Isabel Soto-Cruz Role of the JAK/STAT Pathway in Cervical Cancer: Its Relationship with HPV E6/E7 Oncoproteins Cells signal transducer and activator of transcription STAT inhibitors signaling pathway cervical cancer HPV |
| title | Role of the JAK/STAT Pathway in Cervical Cancer: Its Relationship with HPV E6/E7 Oncoproteins |
| title_full | Role of the JAK/STAT Pathway in Cervical Cancer: Its Relationship with HPV E6/E7 Oncoproteins |
| title_fullStr | Role of the JAK/STAT Pathway in Cervical Cancer: Its Relationship with HPV E6/E7 Oncoproteins |
| title_full_unstemmed | Role of the JAK/STAT Pathway in Cervical Cancer: Its Relationship with HPV E6/E7 Oncoproteins |
| title_short | Role of the JAK/STAT Pathway in Cervical Cancer: Its Relationship with HPV E6/E7 Oncoproteins |
| title_sort | role of the jak stat pathway in cervical cancer its relationship with hpv e6 e7 oncoproteins |
| topic | signal transducer and activator of transcription STAT inhibitors signaling pathway cervical cancer HPV |
| url | https://www.mdpi.com/2073-4409/9/10/2297 |
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