Dexpanthenol prevents ovarian ischemic damage via antioxidant mechanisms in rats
Ovarian torsion is a gynecological emergency characterized by ovarian ischemic damage. This study aimed to investigate the possible protective effects of dexpanthenol (DEX)-an antioxidant molecule-against ovarian ischemic damage in rats. The rats were simple randomly grouped into (1) Sham group (n=8...
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| Format: | Article |
| Language: | English |
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Society of Turaz Bilim
2023-12-01
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| Series: | Medicine Science |
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| Online Access: | https://www.medicinescience.org/?mno=167424 |
| _version_ | 1827353088732692480 |
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| author | Seyhan Polat Ozlem Ekici Ebru Inci Coskun Onural Ozhan Azibe Yildiz Nigar Vardi Zeynep Erdemli Yusuf Turkoz Ahmet Acet Hakan Parlakpinar |
| author_facet | Seyhan Polat Ozlem Ekici Ebru Inci Coskun Onural Ozhan Azibe Yildiz Nigar Vardi Zeynep Erdemli Yusuf Turkoz Ahmet Acet Hakan Parlakpinar |
| author_sort | Seyhan Polat |
| collection | DOAJ |
| description | Ovarian torsion is a gynecological emergency characterized by ovarian ischemic damage. This study aimed to investigate the possible protective effects of dexpanthenol (DEX)-an antioxidant molecule-against ovarian ischemic damage in rats. The rats were simple randomly grouped into (1) Sham group (n=8); (2) Ischemia (I) group (n=8) (2 hours of I in ovaries); (3) DEX+I group (n=8) (500 mg/kg DEX administration 30 minutes before 2 hours of I.) The removed ovaries were examined histopathologically and biochemically. In the DEX+I group, necrosis-pycnosis severity was significantly reduced compared to the I group; but congestion-hemorrhage severity was similar. In the I group, malondialdehyde (MDA) and total oxidant status (TOS) levels were slightly increased, and glutathione (GSH) levels were significantly decreased compared to the Sham group. In the DEX+I group, MDA and TOS levels were slightly reduced and GSH levels were slightly increased compared to the I group. DEX prevents ischemic damage in rat ovaries via an antioxidant effect. Further research is needed to support our findings. [Med-Science 2023; 12(4.000): 1213-7] |
| first_indexed | 2024-03-08T03:19:35Z |
| format | Article |
| id | doaj.art-65150c34d6794fe9a8c3b217441389eb |
| institution | Directory Open Access Journal |
| issn | 2147-0634 |
| language | English |
| last_indexed | 2024-03-08T03:19:35Z |
| publishDate | 2023-12-01 |
| publisher | Society of Turaz Bilim |
| record_format | Article |
| series | Medicine Science |
| spelling | doaj.art-65150c34d6794fe9a8c3b217441389eb2024-02-12T10:32:08ZengSociety of Turaz BilimMedicine Science2147-06342023-12-011241213710.5455/medscience.2023.09.184167424Dexpanthenol prevents ovarian ischemic damage via antioxidant mechanisms in ratsSeyhan Polat0Ozlem Ekici1Ebru Inci Coskun2Onural Ozhan3Azibe Yildiz4Nigar Vardi5Zeynep Erdemli6Yusuf Turkoz7Ahmet Acet8Hakan Parlakpinar9Inonu University, Faculty Of Medicine, Department Of Medical Pharmacology, Malatya, Turkey Undergraduate medical student, faculty of medicine, Inonu University, Malatya, TURKİYE Department of Obstetrics and Gynecology, Inonu University, Malatya, TURKİYE Inonu University, Faculty Of Medicine, Department Of Medical Pharmacology, Malatya, TURKİYE Department of Histology and Embryology, Inonu University, Malatya, TURKİYE Department of Histology and Embryology, Inonu University, Malatya, TURKİYE Department of Medical Biochemistry, Inonu University, Malatya, TURKİYE Department of Medical Biochemistry, Inonu University, Malatya, TURKİYE Inonu University, Faculty Of Medicine, Department Of Medical Pharmacology, Malatya, TURKİYE Inonu University, Faculty Of Medicine, Department Of Medical Pharmacology, Malatya, TURKİYEOvarian torsion is a gynecological emergency characterized by ovarian ischemic damage. This study aimed to investigate the possible protective effects of dexpanthenol (DEX)-an antioxidant molecule-against ovarian ischemic damage in rats. The rats were simple randomly grouped into (1) Sham group (n=8); (2) Ischemia (I) group (n=8) (2 hours of I in ovaries); (3) DEX+I group (n=8) (500 mg/kg DEX administration 30 minutes before 2 hours of I.) The removed ovaries were examined histopathologically and biochemically. In the DEX+I group, necrosis-pycnosis severity was significantly reduced compared to the I group; but congestion-hemorrhage severity was similar. In the I group, malondialdehyde (MDA) and total oxidant status (TOS) levels were slightly increased, and glutathione (GSH) levels were significantly decreased compared to the Sham group. In the DEX+I group, MDA and TOS levels were slightly reduced and GSH levels were slightly increased compared to the I group. DEX prevents ischemic damage in rat ovaries via an antioxidant effect. Further research is needed to support our findings. [Med-Science 2023; 12(4.000): 1213-7]https://www.medicinescience.org/?mno=167424antioxidantdexpanthenolischemiaoxidative stressovary |
| spellingShingle | Seyhan Polat Ozlem Ekici Ebru Inci Coskun Onural Ozhan Azibe Yildiz Nigar Vardi Zeynep Erdemli Yusuf Turkoz Ahmet Acet Hakan Parlakpinar Dexpanthenol prevents ovarian ischemic damage via antioxidant mechanisms in rats Medicine Science antioxidant dexpanthenol ischemia oxidative stress ovary |
| title | Dexpanthenol prevents ovarian ischemic damage via antioxidant mechanisms in rats |
| title_full | Dexpanthenol prevents ovarian ischemic damage via antioxidant mechanisms in rats |
| title_fullStr | Dexpanthenol prevents ovarian ischemic damage via antioxidant mechanisms in rats |
| title_full_unstemmed | Dexpanthenol prevents ovarian ischemic damage via antioxidant mechanisms in rats |
| title_short | Dexpanthenol prevents ovarian ischemic damage via antioxidant mechanisms in rats |
| title_sort | dexpanthenol prevents ovarian ischemic damage via antioxidant mechanisms in rats |
| topic | antioxidant dexpanthenol ischemia oxidative stress ovary |
| url | https://www.medicinescience.org/?mno=167424 |
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