Ketorolac pharmacokinetics in experimental cirrhosis by bile duct ligation in the rat

Ketorolac pharmacokinetics in experimental cirrhosis by bile duct ligation in the rat

The purpose of the present work was to study the pharmacokinetics of ketorolac, a poorly metabolized drug, in experimental cirrhosis. Cirrhosis was induced by bile duct ligation (BDL) for four weeks in male Wistar rats. Ketorolac was given intravenously (1 mg/ kg) or orally (3.2 mg/kg) to control (s...

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Bibliographic Details
Main Authors: Liliana Rivera-Espinosa, PhD, Pablo Muriel, PhD, Mónica Ordaz Gallo, PhD, José Pérez-Urizar, PhD, Antonio Palma-Aguirre, PhD, Gilberto Castañeda-Hernández, PhD
Format: Article
Language:English
Published: Elsevier 2003-10-01
Series:Annals of Hepatology
Subjects:
Ketorolac
pharmacokinetics
cirrhosis
liver damage
bile duct ligation
Online Access:http://www.sciencedirect.com/science/article/pii/S1665268119321301

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