Clinical Profile of Mortality and Treatment Profile of Survival in Patients with COVID-19 Pneumonia Admitted to Dubai Hospital
Background: Most COVID-19 studies conclude old age and coexisting illnesses as mortality determinants owing to different populations or methodologies, or omitting factors affecting outcomes. Methods: We analyzed COVID-19 patients’ data (N = 391) of Dubai Hospital between January 1, 2020 and June 30,...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2021-06-01
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| Series: | Dubai Medical Journal |
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| Online Access: | https://www.karger.com/Article/FullText/516591 |
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| author | Rashid Nadeem Ishma Aijazi Ashraf Elhoufi Crystal Danthi Nouha Azaza Mohd Kafeel Khan Mohannad Alheraki Muhammed Jamshaid Asadullah Nawazani Sadia Tariq Sobia Siddiq Muzammil Hafeez Mukesh Kumar Islam Bon Ahmed Elsousi Lamiaa Salama Sahish Kamat Rami Abdalla |
| author_facet | Rashid Nadeem Ishma Aijazi Ashraf Elhoufi Crystal Danthi Nouha Azaza Mohd Kafeel Khan Mohannad Alheraki Muhammed Jamshaid Asadullah Nawazani Sadia Tariq Sobia Siddiq Muzammil Hafeez Mukesh Kumar Islam Bon Ahmed Elsousi Lamiaa Salama Sahish Kamat Rami Abdalla |
| author_sort | Rashid Nadeem |
| collection | DOAJ |
| description | Background: Most COVID-19 studies conclude old age and coexisting illnesses as mortality determinants owing to different populations or methodologies, or omitting factors affecting outcomes. Methods: We analyzed COVID-19 patients’ data (N = 391) of Dubai Hospital between January 1, 2020 and June 30, 2020. Results: Only 19 patients (4.8%) were UAE nationals, while 372 (95.2%) were expatriates. Median age was 48 (interquartile range, 40–56) years; 22% were <40 years, and only 16.6% were female. Cough was the most common symptom (78.7%), fever was 77.4%, and gastrointestinal symptoms were least common (13.8%). Approximately 95% had elevated C-reactive protein (CRP) and D-dimers (79%), lymphocytopenia 47.3%, and thrombocytopenia 13.8%. Mortality was 30% for the total sample and 50% in ICU patients. ICU patients were older than non-ICU (age; 49.6 ± 10.9 vs. 46.7 ± 12.7 years, p = 0.04). Eighty-five percent of ICU patients required invasive mechanical ventilation, 78% vasopressors, 88% sedation, 84% muscle paralysis, while none require any of these in the medical group. Survivors had fewer patients with sedatives (p = 0.01). The median length of stay in the hospital was 19 days, ICU stays 14 days, and ventilator 11 days. The Mann-Whitney test showed that survivors spent more days in the ICU (median [IQR] 18 [6.5–29.5] vs. 11 [4–18], p value 0.003) and the hospital (32 [14.5–49.5] vs. 14 [7–21], p value 0.001) than nonsurvivors. Ferritin and D-dimers were higher in nonsurvivors, but CRP was lower in nonsurvivors (ferritin (ng/mL) median (IQR) 1,434 (661.5–2206.5) versus 1,362 (630–2,094), p value = 0.017, CRP (mg/L) 118.7 (53.4–184) versus 134.9 (66.5–203.2), p value 0.001 and D-dimer (µg/mL) 1.54 (0–3.13) versus 1.09 (0–2.51), p value = 0.001). Multiple logistic regression analysis determined age, fever on admission, use of oxygen, mechanical ventilation, and steroids as predictors of survival. Conclusions: COVID-19 patients were young males with pre-existing conditions. Ferritin, CRP, and D-dimers were higher in nonsurvivors. Treatment with chloroquine, antivirals, and anticoagulation was not different between survivors and nonsurvivors. Steroid use was a survival predictor. |
| first_indexed | 2024-12-19T23:37:54Z |
| format | Article |
| id | doaj.art-65164a54871445de88fe5c66b88b429a |
| institution | Directory Open Access Journal |
| issn | 2571-726X |
| language | English |
| last_indexed | 2024-12-19T23:37:54Z |
| publishDate | 2021-06-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Dubai Medical Journal |
| spelling | doaj.art-65164a54871445de88fe5c66b88b429a2022-12-21T20:01:33ZengKarger PublishersDubai Medical Journal2571-726X2021-06-0117017610.1159/000516591516591Clinical Profile of Mortality and Treatment Profile of Survival in Patients with COVID-19 Pneumonia Admitted to Dubai HospitalRashid Nadeem0Ishma Aijazi1Ashraf Elhoufi2Crystal Danthi3Nouha Azaza4Mohd Kafeel Khan5https://orcid.org/0000-0002-7494-5854Mohannad Alheraki6Muhammed Jamshaid7Asadullah Nawazani8Sadia Tariq9Sobia Siddiq10Muzammil Hafeez11Mukesh Kumar12Islam Bon13Ahmed Elsousi14Lamiaa Salama15Sahish Kamat16Rami Abdalla17Intensive Care Unit, Dubai Hospital, Dubai, United Arab EmiratesDepartment of Internal Medicine, Dubai Hospital, Dubai, United Arab EmiratesIntensive Care Unit, Dubai Hospital, Dubai, United Arab EmiratesResident, Department of Pediatrics, Dubai Hospital, Dubai, United Arab EmiratesResident, Department of Internal Medicine, Dubai Hospital, Dubai, United Arab EmiratesPediatric Intensive Care Unit, Dubai Hospital, Dubai, United Arab EmiratesDepartment of Internal Medicine, Dubai Hospital, Dubai, United Arab EmiratesDepartment of Internal Medicine, Dubai Hospital, Dubai, United Arab EmiratesDepartment of Internal Medicine, Dubai Hospital, Dubai, United Arab EmiratesDepartment of Internal Medicine, Dubai Hospital, Dubai, United Arab EmiratesDepartment of Internal Medicine, Dubai Hospital, Dubai, United Arab EmiratesNeonatal Intensive Care Unit, Dubai Hospital, Dubai, United Arab EmiratesPediatric Intensive Care Unit, Dubai Hospital, Dubai, United Arab EmiratesIntensive Care Unit, Dubai Hospital, Dubai, United Arab EmiratesIntensive Care Unit, Dubai Hospital, Dubai, United Arab EmiratesIntensive Care Unit, Dubai Hospital, Dubai, United Arab EmiratesIntensive Care Unit, Dubai Hospital, Dubai, United Arab EmiratesIntensive Care Unit, Dubai Hospital, Dubai, United Arab EmiratesBackground: Most COVID-19 studies conclude old age and coexisting illnesses as mortality determinants owing to different populations or methodologies, or omitting factors affecting outcomes. Methods: We analyzed COVID-19 patients’ data (N = 391) of Dubai Hospital between January 1, 2020 and June 30, 2020. Results: Only 19 patients (4.8%) were UAE nationals, while 372 (95.2%) were expatriates. Median age was 48 (interquartile range, 40–56) years; 22% were <40 years, and only 16.6% were female. Cough was the most common symptom (78.7%), fever was 77.4%, and gastrointestinal symptoms were least common (13.8%). Approximately 95% had elevated C-reactive protein (CRP) and D-dimers (79%), lymphocytopenia 47.3%, and thrombocytopenia 13.8%. Mortality was 30% for the total sample and 50% in ICU patients. ICU patients were older than non-ICU (age; 49.6 ± 10.9 vs. 46.7 ± 12.7 years, p = 0.04). Eighty-five percent of ICU patients required invasive mechanical ventilation, 78% vasopressors, 88% sedation, 84% muscle paralysis, while none require any of these in the medical group. Survivors had fewer patients with sedatives (p = 0.01). The median length of stay in the hospital was 19 days, ICU stays 14 days, and ventilator 11 days. The Mann-Whitney test showed that survivors spent more days in the ICU (median [IQR] 18 [6.5–29.5] vs. 11 [4–18], p value 0.003) and the hospital (32 [14.5–49.5] vs. 14 [7–21], p value 0.001) than nonsurvivors. Ferritin and D-dimers were higher in nonsurvivors, but CRP was lower in nonsurvivors (ferritin (ng/mL) median (IQR) 1,434 (661.5–2206.5) versus 1,362 (630–2,094), p value = 0.017, CRP (mg/L) 118.7 (53.4–184) versus 134.9 (66.5–203.2), p value 0.001 and D-dimer (µg/mL) 1.54 (0–3.13) versus 1.09 (0–2.51), p value = 0.001). Multiple logistic regression analysis determined age, fever on admission, use of oxygen, mechanical ventilation, and steroids as predictors of survival. Conclusions: COVID-19 patients were young males with pre-existing conditions. Ferritin, CRP, and D-dimers were higher in nonsurvivors. Treatment with chloroquine, antivirals, and anticoagulation was not different between survivors and nonsurvivors. Steroid use was a survival predictor.https://www.karger.com/Article/FullText/516591covid-19coronasars-cov-2clinical profilesteroidsoutcomeschloroquine |
| spellingShingle | Rashid Nadeem Ishma Aijazi Ashraf Elhoufi Crystal Danthi Nouha Azaza Mohd Kafeel Khan Mohannad Alheraki Muhammed Jamshaid Asadullah Nawazani Sadia Tariq Sobia Siddiq Muzammil Hafeez Mukesh Kumar Islam Bon Ahmed Elsousi Lamiaa Salama Sahish Kamat Rami Abdalla Clinical Profile of Mortality and Treatment Profile of Survival in Patients with COVID-19 Pneumonia Admitted to Dubai Hospital Dubai Medical Journal covid-19 corona sars-cov-2 clinical profile steroids outcomes chloroquine |
| title | Clinical Profile of Mortality and Treatment Profile of Survival in Patients with COVID-19 Pneumonia Admitted to Dubai Hospital |
| title_full | Clinical Profile of Mortality and Treatment Profile of Survival in Patients with COVID-19 Pneumonia Admitted to Dubai Hospital |
| title_fullStr | Clinical Profile of Mortality and Treatment Profile of Survival in Patients with COVID-19 Pneumonia Admitted to Dubai Hospital |
| title_full_unstemmed | Clinical Profile of Mortality and Treatment Profile of Survival in Patients with COVID-19 Pneumonia Admitted to Dubai Hospital |
| title_short | Clinical Profile of Mortality and Treatment Profile of Survival in Patients with COVID-19 Pneumonia Admitted to Dubai Hospital |
| title_sort | clinical profile of mortality and treatment profile of survival in patients with covid 19 pneumonia admitted to dubai hospital |
| topic | covid-19 corona sars-cov-2 clinical profile steroids outcomes chloroquine |
| url | https://www.karger.com/Article/FullText/516591 |
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