Dynamic coupling between the central and autonomic cardiac nervous systems in patients with refractory epilepsy: A pilot study
The heart and brain are reciprocally interconnected and engage in two-way communication for homeostatic regulation. Epilepsy is considered a network disease that also affects the autonomic nervous system (ANS). The neurovisceral integration model (NVM) proposes that cardiac vagal tone, indexed by he...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.904052/full |
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| author | Eline Melo José Fiel Rodrigo Milhomens Thaynara Ribeiro Raphael Navegantes Francinaldo Gomes Bruno Duarte Gomes Bruno Duarte Gomes Antonio Pereira Antonio Pereira Antonio Pereira |
| author_facet | Eline Melo José Fiel Rodrigo Milhomens Thaynara Ribeiro Raphael Navegantes Francinaldo Gomes Bruno Duarte Gomes Bruno Duarte Gomes Antonio Pereira Antonio Pereira Antonio Pereira |
| author_sort | Eline Melo |
| collection | DOAJ |
| description | The heart and brain are reciprocally interconnected and engage in two-way communication for homeostatic regulation. Epilepsy is considered a network disease that also affects the autonomic nervous system (ANS). The neurovisceral integration model (NVM) proposes that cardiac vagal tone, indexed by heart rate variability (HRV), can indicate the functional integrity of cognitive neural networks. ANS activity and the pattern of oscillatory EEG activity covary during the transition of arousal states and associations between cortical and autonomic activity are reflected by HRV. Cognitive dysfunction is one of the common comorbidities that occur in epilepsy, including memory, attention, and processing difficulties. Recent studies have shown evidence for the active involvement of alpha activity in cognitive processes through its active role in the control of neural excitability in the cortex through top-down modulation of cortical networks. In the present pilot study, we evaluated the association between resting EEG oscillatory behavior and ANS function in patients with refractory epilepsy. Our results show: (1) In patients with refractory epilepsy, there is a strong positive correlation between HRV and the power of cortical oscillatory cortical activity in all studied EEG bands (delta, theta, alpha, and beta) in all regions of interest in both hemispheres, the opposite pattern found in controls which had low or negative correlation between these variables; (2) higher heartbeat evoked potential amplitudes in patients with refractory epilepsy than in controls. Taken together, these results point to a significant alteration in heart-brain interaction in patients with refractory epilepsy. |
| first_indexed | 2024-04-11T21:33:00Z |
| format | Article |
| id | doaj.art-6517ce77041b412ea0d9243de060cc98 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-11T21:33:00Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-6517ce77041b412ea0d9243de060cc982022-12-22T04:01:52ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-08-011310.3389/fneur.2022.904052904052Dynamic coupling between the central and autonomic cardiac nervous systems in patients with refractory epilepsy: A pilot studyEline Melo0José Fiel1Rodrigo Milhomens2Thaynara Ribeiro3Raphael Navegantes4Francinaldo Gomes5Bruno Duarte Gomes6Bruno Duarte Gomes7Antonio Pereira8Antonio Pereira9Antonio Pereira10Graduate Program in Neuroscience and Cell Biology, Federal University of Pará, Belém, BrazilGraduate Program in Electrical Engineering, Federal University of Pará, Belém, BrazilDepartment of Electrical and Biomedical Engineering, Institute of Technology, Belém, BrazilDepartment of Electrical and Biomedical Engineering, Institute of Technology, Belém, BrazilGraduate Program in Electrical Engineering, Federal University of Pará, Belém, BrazilHospital Ophir Loyola, Belém, BrazilGraduate Program in Neuroscience and Cell Biology, Federal University of Pará, Belém, BrazilDepartment of Biotechnology, Institute of Biological Sciences, Federal University of Pará, Belém, BrazilGraduate Program in Neuroscience and Cell Biology, Federal University of Pará, Belém, BrazilGraduate Program in Electrical Engineering, Federal University of Pará, Belém, BrazilDepartment of Electrical and Biomedical Engineering, Institute of Technology, Belém, BrazilThe heart and brain are reciprocally interconnected and engage in two-way communication for homeostatic regulation. Epilepsy is considered a network disease that also affects the autonomic nervous system (ANS). The neurovisceral integration model (NVM) proposes that cardiac vagal tone, indexed by heart rate variability (HRV), can indicate the functional integrity of cognitive neural networks. ANS activity and the pattern of oscillatory EEG activity covary during the transition of arousal states and associations between cortical and autonomic activity are reflected by HRV. Cognitive dysfunction is one of the common comorbidities that occur in epilepsy, including memory, attention, and processing difficulties. Recent studies have shown evidence for the active involvement of alpha activity in cognitive processes through its active role in the control of neural excitability in the cortex through top-down modulation of cortical networks. In the present pilot study, we evaluated the association between resting EEG oscillatory behavior and ANS function in patients with refractory epilepsy. Our results show: (1) In patients with refractory epilepsy, there is a strong positive correlation between HRV and the power of cortical oscillatory cortical activity in all studied EEG bands (delta, theta, alpha, and beta) in all regions of interest in both hemispheres, the opposite pattern found in controls which had low or negative correlation between these variables; (2) higher heartbeat evoked potential amplitudes in patients with refractory epilepsy than in controls. Taken together, these results point to a significant alteration in heart-brain interaction in patients with refractory epilepsy.https://www.frontiersin.org/articles/10.3389/fneur.2022.904052/fullrefractory epilepsyheart rate variability (HRV)EEGheartbeat evoked potentialautonomic nervous system (ANS) |
| spellingShingle | Eline Melo José Fiel Rodrigo Milhomens Thaynara Ribeiro Raphael Navegantes Francinaldo Gomes Bruno Duarte Gomes Bruno Duarte Gomes Antonio Pereira Antonio Pereira Antonio Pereira Dynamic coupling between the central and autonomic cardiac nervous systems in patients with refractory epilepsy: A pilot study Frontiers in Neurology refractory epilepsy heart rate variability (HRV) EEG heartbeat evoked potential autonomic nervous system (ANS) |
| title | Dynamic coupling between the central and autonomic cardiac nervous systems in patients with refractory epilepsy: A pilot study |
| title_full | Dynamic coupling between the central and autonomic cardiac nervous systems in patients with refractory epilepsy: A pilot study |
| title_fullStr | Dynamic coupling between the central and autonomic cardiac nervous systems in patients with refractory epilepsy: A pilot study |
| title_full_unstemmed | Dynamic coupling between the central and autonomic cardiac nervous systems in patients with refractory epilepsy: A pilot study |
| title_short | Dynamic coupling between the central and autonomic cardiac nervous systems in patients with refractory epilepsy: A pilot study |
| title_sort | dynamic coupling between the central and autonomic cardiac nervous systems in patients with refractory epilepsy a pilot study |
| topic | refractory epilepsy heart rate variability (HRV) EEG heartbeat evoked potential autonomic nervous system (ANS) |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.904052/full |
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