| Sammanfattning: | <p class="orbitalabstract">An easy and efficient scheme is described designed for the preparation of 4,5-dihydro-1,2,4-oxadiazole using recyclable Cu(OH)x-Clay heterogeneous catalyst at room temperature. The cyclo-addition reaction is carried out between imine and oxime using an easy protocol where nitrile oxides are produced in-situ from aldoximes and reacted with imines to construct 1,2,4-oxadiazolines in good yield and tremendous purity. Cu(OH)x-Clay catalyst shows excellent catalytic activity for the formation of 1,2,4-oxadiazole. The technique is practically uncomplicated, inexpensive, and excellent with wide range of functional group tolerance to generate structurally different 1,2,4-oxadiazoles. The prepared catalyst was investigated by XRD and SEM techniques. The final products of synthesized compound were characterized by FTIR, NMR spectroscopy and mass spectrometry.</p><p class="orbitalabstract"> </p><p class="orbitalabstract">DOI: <a href="http://dx.doi.org/10.17807/orbital.v9i5.1062">http://dx.doi.org/10.17807/orbital.v9i5.1062</a></p><p> </p>
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