Helical micelle of an achiral surfactant from the template interaction with dendrimer
The electrostatic interaction between of poly(amidoamine) (PAMAM) G9 dendrimer and an achiral surfactant, dodecylbenzenesulfonic acid (DBSA), leads to the formation of nucleosome-like structure, where the globular dendrimer molecule directs the DBSA cylindrical micelle to wrap around it spirally wit...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-06-01
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| Series: | Giant |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666542523000097 |
| _version_ | 1797801707601657856 |
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| author | Yi-Cheng Lai Bradley W. Mansel Chun-Yu Chen Chih-Ying Liu Yu-Hsiang Chen Chun-Jen Su U-Ser Jeng Hsin-Lung Chen |
| author_facet | Yi-Cheng Lai Bradley W. Mansel Chun-Yu Chen Chih-Ying Liu Yu-Hsiang Chen Chun-Jen Su U-Ser Jeng Hsin-Lung Chen |
| author_sort | Yi-Cheng Lai |
| collection | DOAJ |
| description | The electrostatic interaction between of poly(amidoamine) (PAMAM) G9 dendrimer and an achiral surfactant, dodecylbenzenesulfonic acid (DBSA), leads to the formation of nucleosome-like structure, where the globular dendrimer molecule directs the DBSA cylindrical micelle to wrap around it spirally with a regular pitch length of 3.2 ∼ 4.3 nm. Molecular dynamics simulation demonstrates that the spherical micelles of DBSA in the aqueous solution first condense on the dendrimer surface via the electrostatic attraction. The micelles then merge with their neighbors to form cylinders bending around the dendrimer, which further connect with one another to form a spring-like helix wrapping around the dendrimer. The discovery of the helical supramolecular structure attests the universality of soft cylindrical building block such as DNA and micelle to twist and wrap helically around the oppositely charged particle such as histone protein and dendrimer for attaining the optimal charge matching at the expense of the bending energy of the cylinder. |
| first_indexed | 2024-03-13T04:54:35Z |
| format | Article |
| id | doaj.art-6518fdc9ece447b9b588bc706f4cba60 |
| institution | Directory Open Access Journal |
| issn | 2666-5425 |
| language | English |
| last_indexed | 2024-03-13T04:54:35Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Giant |
| spelling | doaj.art-6518fdc9ece447b9b588bc706f4cba602023-06-18T05:03:26ZengElsevierGiant2666-54252023-06-0114100147Helical micelle of an achiral surfactant from the template interaction with dendrimerYi-Cheng Lai0Bradley W. Mansel1Chun-Yu Chen2Chih-Ying Liu3Yu-Hsiang Chen4Chun-Jen Su5U-Ser Jeng6Hsin-Lung Chen7Department of Chemical Engineering, National Tsing Hua University, Hsinchu 300044, TaiwanNational Synchrotron Radiation Research Center, Hsinchu 30076, TaiwanNational Synchrotron Radiation Research Center, Hsinchu 30076, TaiwanDepartment of Chemical Engineering, National Tsing Hua University, Hsinchu 300044, TaiwanDepartment of Chemical Engineering, National Tsing Hua University, Hsinchu 300044, TaiwanNational Synchrotron Radiation Research Center, Hsinchu 30076, TaiwanDepartment of Chemical Engineering, National Tsing Hua University, Hsinchu 300044, Taiwan; National Synchrotron Radiation Research Center, Hsinchu 30076, TaiwanDepartment of Chemical Engineering, National Tsing Hua University, Hsinchu 300044, Taiwan; Corresponding author.The electrostatic interaction between of poly(amidoamine) (PAMAM) G9 dendrimer and an achiral surfactant, dodecylbenzenesulfonic acid (DBSA), leads to the formation of nucleosome-like structure, where the globular dendrimer molecule directs the DBSA cylindrical micelle to wrap around it spirally with a regular pitch length of 3.2 ∼ 4.3 nm. Molecular dynamics simulation demonstrates that the spherical micelles of DBSA in the aqueous solution first condense on the dendrimer surface via the electrostatic attraction. The micelles then merge with their neighbors to form cylinders bending around the dendrimer, which further connect with one another to form a spring-like helix wrapping around the dendrimer. The discovery of the helical supramolecular structure attests the universality of soft cylindrical building block such as DNA and micelle to twist and wrap helically around the oppositely charged particle such as histone protein and dendrimer for attaining the optimal charge matching at the expense of the bending energy of the cylinder.http://www.sciencedirect.com/science/article/pii/S2666542523000097PAMAM dendrimerDBSAMicelleElectrostatic complexationHelix |
| spellingShingle | Yi-Cheng Lai Bradley W. Mansel Chun-Yu Chen Chih-Ying Liu Yu-Hsiang Chen Chun-Jen Su U-Ser Jeng Hsin-Lung Chen Helical micelle of an achiral surfactant from the template interaction with dendrimer Giant PAMAM dendrimer DBSA Micelle Electrostatic complexation Helix |
| title | Helical micelle of an achiral surfactant from the template interaction with dendrimer |
| title_full | Helical micelle of an achiral surfactant from the template interaction with dendrimer |
| title_fullStr | Helical micelle of an achiral surfactant from the template interaction with dendrimer |
| title_full_unstemmed | Helical micelle of an achiral surfactant from the template interaction with dendrimer |
| title_short | Helical micelle of an achiral surfactant from the template interaction with dendrimer |
| title_sort | helical micelle of an achiral surfactant from the template interaction with dendrimer |
| topic | PAMAM dendrimer DBSA Micelle Electrostatic complexation Helix |
| url | http://www.sciencedirect.com/science/article/pii/S2666542523000097 |
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