Elaiophylin Inhibits Tumorigenesis of Human Lung Adenocarcinoma by Inhibiting Mitophagy via Suppression of SIRT1/Nrf2 Signaling

Elaiophylin Inhibits Tumorigenesis of Human Lung Adenocarcinoma by Inhibiting Mitophagy via Suppression of SIRT1/Nrf2 Signaling

Lung adenocarcinoma (LADC), the most common type of lung cancer, is still one of the most aggressive and rapidly fatal tumor types, even though achievements in new therapeutic approaches have been developed. Elaiophylin as a C2 symmetrically glycosylated 16 macrolides has been reported to be a late-...

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Bibliographic Details
Main Authors: Jiali Ji, Ke Wang, Xinmin Meng, Hongqin Zhong, Xiyue Li, Hongqing Zhao, Guijuan Xie, Yunying Xie, Xun Wang, Xue Zhu
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cancers
Subjects:
lung adenocarcinoma
elaiophylin
mitophagy
oxidative stress
SIRT1/Nrf2 signaling
Online Access:https://www.mdpi.com/2072-6694/14/23/5812

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