Human Respiratory Syncytial Virus Epidemiological Burden in Pediatric Outpatients in Italy: A Systematic Review
Background: Human respiratory syncytial virus (hRSV) is a key contributor to lower respiratory tract infections (LRTIs), affecting children aged 0–5 years and often leading to outpatient visits, emergency department utilization, and hospitalization. With the development of hRSV vaccines for mitigati...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/11/9/1484 |
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| author | Sara Boccalini Benedetta Bonito Cristina Salvati Marco Del Riccio Enrica Stancanelli Mario Bruschi Giulia Ionita Johanna Iamarino Davide Bentivegna Primo Buscemi Giulia Ciardi Claudia Cosma Lorenzo Stacchini Cristiana Conticello Manjola Bega Annamaria Schirripa Sonia Paoli Lorenzo Bertizzolo Salvatore Parisi Francesca Trippi Paolo Bonanni Angela Bechini |
| author_facet | Sara Boccalini Benedetta Bonito Cristina Salvati Marco Del Riccio Enrica Stancanelli Mario Bruschi Giulia Ionita Johanna Iamarino Davide Bentivegna Primo Buscemi Giulia Ciardi Claudia Cosma Lorenzo Stacchini Cristiana Conticello Manjola Bega Annamaria Schirripa Sonia Paoli Lorenzo Bertizzolo Salvatore Parisi Francesca Trippi Paolo Bonanni Angela Bechini |
| author_sort | Sara Boccalini |
| collection | DOAJ |
| description | Background: Human respiratory syncytial virus (hRSV) is a key contributor to lower respiratory tract infections (LRTIs), affecting children aged 0–5 years and often leading to outpatient visits, emergency department utilization, and hospitalization. With the development of hRSV vaccines for mitigation, understanding the epidemiological impact of hRSV infections among 0–5-year-old pediatric outpatients in Italy is crucial. Methods: This systematic review conducted searches on PubMed, Embase, Scopus, and the International HTA Database, yielding 20,845 English and Italian records from January 2000 to July 2022. Results: Six eligible articles were identified following inclusion and exclusion criteria. These studies demonstrated hRSV-positivity proportions ranging from 18% to 41% in pediatric outpatients with respiratory infections. However, data comparability was hindered by diverse diagnostic approaches, data sources, sample populations, and study designs. Notably, hRSV-positivity showed temporal variability, rising from 23.8% (2001–2002) to 40.6% (2019–2020). This trend could stem from evolving epidemiological factors, heightened clinician awareness in hRSV diagnosis, or more sensitive molecular techniques. Conclusion: As the first review of its kind, this study underscores the need for more comprehensive data to inform effective preventive strategies against hRSV-related burdens in pediatric outpatients. |
| first_indexed | 2024-03-10T21:52:31Z |
| format | Article |
| id | doaj.art-651a9e02e098497e895266a49ab89321 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T21:52:31Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-651a9e02e098497e895266a49ab893212023-11-19T13:19:36ZengMDPI AGVaccines2076-393X2023-09-01119148410.3390/vaccines11091484Human Respiratory Syncytial Virus Epidemiological Burden in Pediatric Outpatients in Italy: A Systematic ReviewSara Boccalini0Benedetta Bonito1Cristina Salvati2Marco Del Riccio3Enrica Stancanelli4Mario Bruschi5Giulia Ionita6Johanna Iamarino7Davide Bentivegna8Primo Buscemi9Giulia Ciardi10Claudia Cosma11Lorenzo Stacchini12Cristiana Conticello13Manjola Bega14Annamaria Schirripa15Sonia Paoli16Lorenzo Bertizzolo17Salvatore Parisi18Francesca Trippi19Paolo Bonanni20Angela Bechini21Department of Health Sciences, University of Florence, 50134 Florence, ItalyDepartment of Health Sciences, University of Florence, 50134 Florence, ItalyDepartment of Health Sciences, University of Florence, 50134 Florence, ItalyDepartment of Health Sciences, University of Florence, 50134 Florence, ItalyMedical Specialization School of Hygiene and Preventive Medicine, University of Florence, 50134 Florence, ItalyMedical Specialization School of Hygiene and Preventive Medicine, University of Florence, 50134 Florence, ItalyMedical Specialization School of Hygiene and Preventive Medicine, University of Florence, 50134 Florence, ItalyMedical Specialization School of Hygiene and Preventive Medicine, University of Florence, 50134 Florence, ItalyMedical Specialization School of Hygiene and Preventive Medicine, University of Florence, 50134 Florence, ItalyMedical Specialization School of Hygiene and Preventive Medicine, University of Florence, 50134 Florence, ItalyMedical Specialization School of Hygiene and Preventive Medicine, University of Florence, 50134 Florence, ItalyMedical Specialization School of Hygiene and Preventive Medicine, University of Florence, 50134 Florence, ItalyMedical Specialization School of Hygiene and Preventive Medicine, University of Florence, 50134 Florence, ItalyMedical Specialization School of Hygiene and Preventive Medicine, University of Florence, 50134 Florence, ItalyMedical Specialization School of Hygiene and Preventive Medicine, University of Florence, 50134 Florence, ItalyMedical Specialization School of Hygiene and Preventive Medicine, University of Florence, 50134 Florence, ItalyMedical Specialization School of Hygiene and Preventive Medicine, University of Florence, 50134 Florence, ItalySanofi, 14 Espa. Henry Vallée, 69007 Lyon, FranceSanofi, Medical Affairs, Viale L. Bodio, 37/b, 20158 Milan, ItalySanofi, Medical Affairs, Viale L. Bodio, 37/b, 20158 Milan, ItalyDepartment of Health Sciences, University of Florence, 50134 Florence, ItalyDepartment of Health Sciences, University of Florence, 50134 Florence, ItalyBackground: Human respiratory syncytial virus (hRSV) is a key contributor to lower respiratory tract infections (LRTIs), affecting children aged 0–5 years and often leading to outpatient visits, emergency department utilization, and hospitalization. With the development of hRSV vaccines for mitigation, understanding the epidemiological impact of hRSV infections among 0–5-year-old pediatric outpatients in Italy is crucial. Methods: This systematic review conducted searches on PubMed, Embase, Scopus, and the International HTA Database, yielding 20,845 English and Italian records from January 2000 to July 2022. Results: Six eligible articles were identified following inclusion and exclusion criteria. These studies demonstrated hRSV-positivity proportions ranging from 18% to 41% in pediatric outpatients with respiratory infections. However, data comparability was hindered by diverse diagnostic approaches, data sources, sample populations, and study designs. Notably, hRSV-positivity showed temporal variability, rising from 23.8% (2001–2002) to 40.6% (2019–2020). This trend could stem from evolving epidemiological factors, heightened clinician awareness in hRSV diagnosis, or more sensitive molecular techniques. Conclusion: As the first review of its kind, this study underscores the need for more comprehensive data to inform effective preventive strategies against hRSV-related burdens in pediatric outpatients.https://www.mdpi.com/2076-393X/11/9/1484RSVambulatoryepidemiologychildrenhRSV-AhRSV-B |
| spellingShingle | Sara Boccalini Benedetta Bonito Cristina Salvati Marco Del Riccio Enrica Stancanelli Mario Bruschi Giulia Ionita Johanna Iamarino Davide Bentivegna Primo Buscemi Giulia Ciardi Claudia Cosma Lorenzo Stacchini Cristiana Conticello Manjola Bega Annamaria Schirripa Sonia Paoli Lorenzo Bertizzolo Salvatore Parisi Francesca Trippi Paolo Bonanni Angela Bechini Human Respiratory Syncytial Virus Epidemiological Burden in Pediatric Outpatients in Italy: A Systematic Review Vaccines RSV ambulatory epidemiology children hRSV-A hRSV-B |
| title | Human Respiratory Syncytial Virus Epidemiological Burden in Pediatric Outpatients in Italy: A Systematic Review |
| title_full | Human Respiratory Syncytial Virus Epidemiological Burden in Pediatric Outpatients in Italy: A Systematic Review |
| title_fullStr | Human Respiratory Syncytial Virus Epidemiological Burden in Pediatric Outpatients in Italy: A Systematic Review |
| title_full_unstemmed | Human Respiratory Syncytial Virus Epidemiological Burden in Pediatric Outpatients in Italy: A Systematic Review |
| title_short | Human Respiratory Syncytial Virus Epidemiological Burden in Pediatric Outpatients in Italy: A Systematic Review |
| title_sort | human respiratory syncytial virus epidemiological burden in pediatric outpatients in italy a systematic review |
| topic | RSV ambulatory epidemiology children hRSV-A hRSV-B |
| url | https://www.mdpi.com/2076-393X/11/9/1484 |
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