Generation of gene-corrected isogenic controls from Parkinson's disease patient iPSC lines carrying the pathogenic SNCA p.A53T variant
Pathogenic variants in the alpha-synuclein (SNCA) gene cause familial forms of Parkinson’s disease (PD). Here, we describe generation of six isogenic controls from iPS cell lines derived from two PD disease patients carrying the SNCAp.A53T variant. The controls were created using CRISPR/Cas9 technol...
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Format: | Article |
Language: | English |
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Elsevier
2023-06-01
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Series: | Stem Cell Research |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506123001113 |
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author | Nikita Kozhushko Aleksandra Beilina Mark R. Cookson |
author_facet | Nikita Kozhushko Aleksandra Beilina Mark R. Cookson |
author_sort | Nikita Kozhushko |
collection | DOAJ |
description | Pathogenic variants in the alpha-synuclein (SNCA) gene cause familial forms of Parkinson’s disease (PD). Here, we describe generation of six isogenic controls from iPS cell lines derived from two PD disease patients carrying the SNCAp.A53T variant. The controls were created using CRISPR/Cas9 technology and are available for use by the PD research community to study A53T-related synucleinopathies. |
first_indexed | 2024-03-13T08:28:53Z |
format | Article |
id | doaj.art-651b18ada7714338ba734253e6662f87 |
institution | Directory Open Access Journal |
issn | 1873-5061 |
language | English |
last_indexed | 2024-03-13T08:28:53Z |
publishDate | 2023-06-01 |
publisher | Elsevier |
record_format | Article |
series | Stem Cell Research |
spelling | doaj.art-651b18ada7714338ba734253e6662f872023-05-31T04:44:17ZengElsevierStem Cell Research1873-50612023-06-0169103125Generation of gene-corrected isogenic controls from Parkinson's disease patient iPSC lines carrying the pathogenic SNCA p.A53T variantNikita Kozhushko0Aleksandra Beilina1Mark R. Cookson2Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USALaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USACorresponding author.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USAPathogenic variants in the alpha-synuclein (SNCA) gene cause familial forms of Parkinson’s disease (PD). Here, we describe generation of six isogenic controls from iPS cell lines derived from two PD disease patients carrying the SNCAp.A53T variant. The controls were created using CRISPR/Cas9 technology and are available for use by the PD research community to study A53T-related synucleinopathies.http://www.sciencedirect.com/science/article/pii/S1873506123001113 |
spellingShingle | Nikita Kozhushko Aleksandra Beilina Mark R. Cookson Generation of gene-corrected isogenic controls from Parkinson's disease patient iPSC lines carrying the pathogenic SNCA p.A53T variant Stem Cell Research |
title | Generation of gene-corrected isogenic controls from Parkinson's disease patient iPSC lines carrying the pathogenic SNCA p.A53T variant |
title_full | Generation of gene-corrected isogenic controls from Parkinson's disease patient iPSC lines carrying the pathogenic SNCA p.A53T variant |
title_fullStr | Generation of gene-corrected isogenic controls from Parkinson's disease patient iPSC lines carrying the pathogenic SNCA p.A53T variant |
title_full_unstemmed | Generation of gene-corrected isogenic controls from Parkinson's disease patient iPSC lines carrying the pathogenic SNCA p.A53T variant |
title_short | Generation of gene-corrected isogenic controls from Parkinson's disease patient iPSC lines carrying the pathogenic SNCA p.A53T variant |
title_sort | generation of gene corrected isogenic controls from parkinson s disease patient ipsc lines carrying the pathogenic snca p a53t variant |
url | http://www.sciencedirect.com/science/article/pii/S1873506123001113 |
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