Efficacy of intra-arterial nimodipine therapy in the treatment of vasospasm after subarachnoid hemorrhage
Background: This study aims to investigate the efficacy of intra-arterial nimodipine therapy in treating patients that presented with spontaneous subarachnoid hemorrhage and developed vasospasm following aneurysm surgery. Methods: The study includes 37 patients that underwent intra-arterial nimodipi...
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| Format: | Article |
| Language: | English |
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Rabia Yılmaz
2020-06-01
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| Series: | Journal of Contemporary Medicine |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/tr/download/article-file/1162651 |
| _version_ | 1797860678079348736 |
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| author | Vedat Açık |
| author_facet | Vedat Açık |
| author_sort | Vedat Açık |
| collection | DOAJ |
| description | Background: This study aims to investigate the efficacy of intra-arterial nimodipine therapy in treating patients that presented with spontaneous subarachnoid hemorrhage and developed vasospasm following aneurysm surgery.
Methods: The study includes 37 patients that underwent intra-arterial nimodipine therapy for the treatment of cerebral vasospasm between October 2015 and December 2019. In patients that developed vasospasm, a catheter was selectively inserted into the internal carotid artery, 1–2 mg of nimodipine was diluted with 50 ccs of saline, and was slowly infused through the catheter.
Results: In our study, we found the success rate of intra-arterial nimodipine administration to be 78.4% (neurologic findings completely improved in 29 cases). The clinical condition did not improve in 13.5% of cases and worsened in 8.1%. 86.4% of our patients were discharged with good outcomes (mRS score 0–1).
Conclusion: We conclude that intra-arterial nimodipine therapy is a cost-effective, safe, and successful method for the treatment of cerebral vasospasm, a condition that directly affects morbidity and mortality after subarachnoid hemorrhage. Prospective studies are needed to determine standard doses and application times in order to establish the efficacy of intra-arterial nimodipine therapy in treating cerebral vasospasm. |
| first_indexed | 2024-04-09T21:49:49Z |
| format | Article |
| id | doaj.art-651eba73842c4206a7afaa916d822eb9 |
| institution | Directory Open Access Journal |
| issn | 2667-7180 |
| language | English |
| last_indexed | 2024-04-09T21:49:49Z |
| publishDate | 2020-06-01 |
| publisher | Rabia Yılmaz |
| record_format | Article |
| series | Journal of Contemporary Medicine |
| spelling | doaj.art-651eba73842c4206a7afaa916d822eb92023-03-24T19:43:23ZengRabia YılmazJournal of Contemporary Medicine2667-71802020-06-0110221321910.16899/jcm.7377041809Efficacy of intra-arterial nimodipine therapy in the treatment of vasospasm after subarachnoid hemorrhageVedat Açık0Adana Şehir Eğitim ve Araştırma HastanesiBackground: This study aims to investigate the efficacy of intra-arterial nimodipine therapy in treating patients that presented with spontaneous subarachnoid hemorrhage and developed vasospasm following aneurysm surgery. Methods: The study includes 37 patients that underwent intra-arterial nimodipine therapy for the treatment of cerebral vasospasm between October 2015 and December 2019. In patients that developed vasospasm, a catheter was selectively inserted into the internal carotid artery, 1–2 mg of nimodipine was diluted with 50 ccs of saline, and was slowly infused through the catheter. Results: In our study, we found the success rate of intra-arterial nimodipine administration to be 78.4% (neurologic findings completely improved in 29 cases). The clinical condition did not improve in 13.5% of cases and worsened in 8.1%. 86.4% of our patients were discharged with good outcomes (mRS score 0–1). Conclusion: We conclude that intra-arterial nimodipine therapy is a cost-effective, safe, and successful method for the treatment of cerebral vasospasm, a condition that directly affects morbidity and mortality after subarachnoid hemorrhage. Prospective studies are needed to determine standard doses and application times in order to establish the efficacy of intra-arterial nimodipine therapy in treating cerebral vasospasm.https://dergipark.org.tr/tr/download/article-file/1162651spontaneous subarachnoid hemorrhage |
| spellingShingle | Vedat Açık Efficacy of intra-arterial nimodipine therapy in the treatment of vasospasm after subarachnoid hemorrhage Journal of Contemporary Medicine spontaneous subarachnoid hemorrhage |
| title | Efficacy of intra-arterial nimodipine therapy in the treatment of vasospasm after subarachnoid hemorrhage |
| title_full | Efficacy of intra-arterial nimodipine therapy in the treatment of vasospasm after subarachnoid hemorrhage |
| title_fullStr | Efficacy of intra-arterial nimodipine therapy in the treatment of vasospasm after subarachnoid hemorrhage |
| title_full_unstemmed | Efficacy of intra-arterial nimodipine therapy in the treatment of vasospasm after subarachnoid hemorrhage |
| title_short | Efficacy of intra-arterial nimodipine therapy in the treatment of vasospasm after subarachnoid hemorrhage |
| title_sort | efficacy of intra arterial nimodipine therapy in the treatment of vasospasm after subarachnoid hemorrhage |
| topic | spontaneous subarachnoid hemorrhage |
| url | https://dergipark.org.tr/tr/download/article-file/1162651 |
| work_keys_str_mv | AT vedatacık efficacyofintraarterialnimodipinetherapyinthetreatmentofvasospasmaftersubarachnoidhemorrhage |