The Microenvironment in Gliomas: Phenotypic Expressions
The microenvironment of malignant gliomas is described according to its definition in the literature. Beside tumor cells, a series of stromal cells (microglia/macrophages, pericytes, fibroblasts, endothelial cells, normal and reactive astrocytes) represents the cell component, whereas a complex netw...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-12-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6694/7/4/0896 |
| _version_ | 1797757894095011840 |
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| author | Davide Schiffer Laura Annovazzi Marta Mazzucco Marta Mellai |
| author_facet | Davide Schiffer Laura Annovazzi Marta Mazzucco Marta Mellai |
| author_sort | Davide Schiffer |
| collection | DOAJ |
| description | The microenvironment of malignant gliomas is described according to its definition in the literature. Beside tumor cells, a series of stromal cells (microglia/macrophages, pericytes, fibroblasts, endothelial cells, normal and reactive astrocytes) represents the cell component, whereas a complex network of molecular signaling represents the functional component. Its most evident expressions are perivascular and perinecrotic niches that are believed to be the site of tumor stem cells or progenitors in the tumor. Phenotypically, both niches are not easily recognizable; here, they are described together with a critical revision of their concept. As for perinecrotic niches, an alternative interpretation is given about their origin that regards the tumor stem cells as the residue of those that populated hyperproliferating areas in which necroses develop. This is based on the concept that the stem-like is a status and not a cell type, depending on the microenvironment that regulates a conversion of tumor non-stem cells and tumor stem cells through a cell reprogramming. |
| first_indexed | 2024-03-12T18:21:10Z |
| format | Article |
| id | doaj.art-652025c6efd14aaebdac1271f4ef4314 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T18:21:10Z |
| publishDate | 2015-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-652025c6efd14aaebdac1271f4ef43142023-08-02T08:50:25ZengMDPI AGCancers2072-66942015-12-01742352235910.3390/cancers7040896cancers7040896The Microenvironment in Gliomas: Phenotypic ExpressionsDavide Schiffer0Laura Annovazzi1Marta Mazzucco2Marta Mellai3Research Center, Policlinico di Monza Foundation, Via Pietro Micca 29, 13100 Vercelli, ItalyResearch Center, Policlinico di Monza Foundation, Via Pietro Micca 29, 13100 Vercelli, ItalyResearch Center, Policlinico di Monza Foundation, Via Pietro Micca 29, 13100 Vercelli, ItalyResearch Center, Policlinico di Monza Foundation, Via Pietro Micca 29, 13100 Vercelli, ItalyThe microenvironment of malignant gliomas is described according to its definition in the literature. Beside tumor cells, a series of stromal cells (microglia/macrophages, pericytes, fibroblasts, endothelial cells, normal and reactive astrocytes) represents the cell component, whereas a complex network of molecular signaling represents the functional component. Its most evident expressions are perivascular and perinecrotic niches that are believed to be the site of tumor stem cells or progenitors in the tumor. Phenotypically, both niches are not easily recognizable; here, they are described together with a critical revision of their concept. As for perinecrotic niches, an alternative interpretation is given about their origin that regards the tumor stem cells as the residue of those that populated hyperproliferating areas in which necroses develop. This is based on the concept that the stem-like is a status and not a cell type, depending on the microenvironment that regulates a conversion of tumor non-stem cells and tumor stem cells through a cell reprogramming.http://www.mdpi.com/2072-6694/7/4/0896stem cellsmicroenvironmentniches |
| spellingShingle | Davide Schiffer Laura Annovazzi Marta Mazzucco Marta Mellai The Microenvironment in Gliomas: Phenotypic Expressions Cancers stem cells microenvironment niches |
| title | The Microenvironment in Gliomas: Phenotypic Expressions |
| title_full | The Microenvironment in Gliomas: Phenotypic Expressions |
| title_fullStr | The Microenvironment in Gliomas: Phenotypic Expressions |
| title_full_unstemmed | The Microenvironment in Gliomas: Phenotypic Expressions |
| title_short | The Microenvironment in Gliomas: Phenotypic Expressions |
| title_sort | microenvironment in gliomas phenotypic expressions |
| topic | stem cells microenvironment niches |
| url | http://www.mdpi.com/2072-6694/7/4/0896 |
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