Transcriptome Profiling of Bovine Macrophages Infected by Mycobacterium avium spp. paratuberculosis Depicts Foam Cell and Innate Immune Tolerance Phenotypes

Transcriptome Profiling of Bovine Macrophages Infected by Mycobacterium avium spp. paratuberculosis Depicts Foam Cell and Innate Immune Tolerance Phenotypes

Mycobacterium avium spp. paratuberculosis (MAP) is the causative agent of Johne's disease (JD), also known as paratuberculosis, in ruminants. The mechanisms of JD pathogenesis are not fully understood, but it is known that MAP subverts the host immune system by using macrophages as its primary...

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Bibliographic Details
Main Authors: Olivier Ariel, Daniel Gendron, Pier-Luc Dudemaine, Nicolas Gévry, Eveline M. Ibeagha-Awemu, Nathalie Bissonnette
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
Mycobacterium avium spp. paratuberculosis
bovine
paratuberculosis
macrophage
innate immunity
immune tolerance
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02874/full

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