Optical genome mapping identifies rare structural variations as predisposition factors associated with severe COVID-19

Optical genome mapping identifies rare structural variations as predisposition factors associated with severe COVID-19

Summary: Impressive global efforts have identified both rare and common gene variants associated with severe COVID-19 using sequencing technologies. However, these studies lack the sensitivity to accurately detect several classes of variants, especially large structural variants (SVs), which account...

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Bibliographic Details
Main Authors: Nikhil Shri Sahajpal, Chi-Yu Jill Lai, Alex Hastie, Ashis K. Mondal, Siavash Raeisi Dehkordi, Caspar I. van der Made, Olivier Fedrigo, Farooq Al-Ajli, Sawan Jalnapurkar, Marta Byrska-Bishop, Rashmi Kanagal-Shamanna, Brynn Levy, Maximilian Schieck, Thomas Illig, Silviu-Alin Bacanu, Janet S. Chou, Adrienne G. Randolph, Amyn M. Rojiani, Michael C. Zody, Catherine A. Brownstein, Alan H. Beggs, Vineet Bafna, Erich D. Jarvis, Alexander Hoischen, Alka Chaubey, Ravindra Kolhe
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:iScience
Subjects:
Genetic sample
Genomics
Virology
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422200030X

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