Fatty acid oxidation: driver of lymph node metastasis
Abstract Fatty acid oxidation (FAO) is the emerging hallmark of cancer metabolism because certain tumor cells preferentially utilize fatty acids for energy. Lymph node metastasis, the most common way of tumor metastasis, is much indispensable for grasping tumor progression, formulating therapy measu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-07-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12935-021-02057-w |
| _version_ | 1818440758788620288 |
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| author | Mao Li Hong-chun Xian Ya-Jie Tang Xin-hua Liang Ya-ling Tang |
| author_facet | Mao Li Hong-chun Xian Ya-Jie Tang Xin-hua Liang Ya-ling Tang |
| author_sort | Mao Li |
| collection | DOAJ |
| description | Abstract Fatty acid oxidation (FAO) is the emerging hallmark of cancer metabolism because certain tumor cells preferentially utilize fatty acids for energy. Lymph node metastasis, the most common way of tumor metastasis, is much indispensable for grasping tumor progression, formulating therapy measure and evaluating tumor prognosis. There is a plethora of studies showing different ways how tumor cells metastasize to the lymph nodes, but the role of FAO in lymph node metastasis remains largely unknown. Here, we summarize recent findings and update the current understanding that FAO may enable lymph node metastasis formation. Afterward, it will open innovative possibilities to present a distinct therapy of targeting FAO, the metabolic rewiring of cancer to terminal cancer patients. |
| first_indexed | 2024-12-14T18:17:27Z |
| format | Article |
| id | doaj.art-65251b02dbb6439a800ccc0ec4e30a9d |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-12-14T18:17:27Z |
| publishDate | 2021-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-65251b02dbb6439a800ccc0ec4e30a9d2022-12-21T22:52:10ZengBMCCancer Cell International1475-28672021-07-0121111310.1186/s12935-021-02057-wFatty acid oxidation: driver of lymph node metastasisMao Li0Hong-chun Xian1Ya-Jie Tang2Xin-hua Liang3Ya-ling Tang4State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Department of Oral Pathology, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Department of Oral Pathology, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Microbial Technology, Shandong UniversityState Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Department of Oral Pathology, West China Hospital of Stomatology, Sichuan UniversityAbstract Fatty acid oxidation (FAO) is the emerging hallmark of cancer metabolism because certain tumor cells preferentially utilize fatty acids for energy. Lymph node metastasis, the most common way of tumor metastasis, is much indispensable for grasping tumor progression, formulating therapy measure and evaluating tumor prognosis. There is a plethora of studies showing different ways how tumor cells metastasize to the lymph nodes, but the role of FAO in lymph node metastasis remains largely unknown. Here, we summarize recent findings and update the current understanding that FAO may enable lymph node metastasis formation. Afterward, it will open innovative possibilities to present a distinct therapy of targeting FAO, the metabolic rewiring of cancer to terminal cancer patients.https://doi.org/10.1186/s12935-021-02057-wFatty acid oxidationLymph node metastasisYAPLymph node pre-metastatic nicheMetabolic reprogrammingImmune suppression |
| spellingShingle | Mao Li Hong-chun Xian Ya-Jie Tang Xin-hua Liang Ya-ling Tang Fatty acid oxidation: driver of lymph node metastasis Cancer Cell International Fatty acid oxidation Lymph node metastasis YAP Lymph node pre-metastatic niche Metabolic reprogramming Immune suppression |
| title | Fatty acid oxidation: driver of lymph node metastasis |
| title_full | Fatty acid oxidation: driver of lymph node metastasis |
| title_fullStr | Fatty acid oxidation: driver of lymph node metastasis |
| title_full_unstemmed | Fatty acid oxidation: driver of lymph node metastasis |
| title_short | Fatty acid oxidation: driver of lymph node metastasis |
| title_sort | fatty acid oxidation driver of lymph node metastasis |
| topic | Fatty acid oxidation Lymph node metastasis YAP Lymph node pre-metastatic niche Metabolic reprogramming Immune suppression |
| url | https://doi.org/10.1186/s12935-021-02057-w |
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