Association of triglyceride-glucose index with myocardial injury post-stroke in older patients with first-ever ischemic stroke
Abstract Background Myocardial injury post-stroke is a common sequela of acute stroke. Triglyceride-glucose index (TyG index), a valuable surrogate indicator of insulin resistance, has been suggested to be closely related to cardiovascular outcomes. However, it is unknown whether the TyG index is in...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | BMC Geriatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12877-023-04041-7 |
| _version_ | 1797806507091296256 |
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| author | Mu Niu Zhikang Zhou Long Wang Jian Yang Miao Sun Xin Lv Faqiang Zhang |
| author_facet | Mu Niu Zhikang Zhou Long Wang Jian Yang Miao Sun Xin Lv Faqiang Zhang |
| author_sort | Mu Niu |
| collection | DOAJ |
| description | Abstract Background Myocardial injury post-stroke is a common sequela of acute stroke. Triglyceride-glucose index (TyG index), a valuable surrogate indicator of insulin resistance, has been suggested to be closely related to cardiovascular outcomes. However, it is unknown whether the TyG index is independently associated with a higher risk of myocardial injury post-stroke. We therefore investigated the longitudinal association between TyG index and risk of myocardial injury post-stroke in older patients with first-ever ischemic stroke and no prior cardiovascular comorbidities. Methods We included older patients with first-ever ischemic stroke and no prior cardiovascular comorbidities between January 2021 to December 2021. The individuals were stratified into low and high TyG index groups according to the optimal cutoff value with TyG index. We performed logistic regression analysis, propensity score matching (PSM) analysis, restricted cubic spline analysis, and subgroup analyses to explore the longitudinal association between TyG index and risk of myocardial injury post-stroke. Results We included 386 individuals with a median age of 69.8 years (interquartile range: 66.6, 75.3). The optimal TyG index cut-off for predicting myocardial injury post-stroke was 8.9 (sensitivity 67.8%; specificity 75.5%; area under curve 0.701). Multivariate logistic regression analysis revealed that the risk of genesis of myocardial injury post-stroke increased with elevated TyG index (odds ratio [OR], 2.333; 95% confidence interval [CI], 1.201–4.585; P = 0.013). Furthermore, all covariates were well balanced between the two groups. The longitudinal association between TyG index and myocardial injury post-stroke remained significantly robust (OR: 2.196; 95% CI: 1.416–3.478; P < 0.001) after PSM adjustment. Conclusion Individuals with an elevated TyG index were more susceptible to having an increased risk of myocardial injury post-stroke. TyG index thus might be served as a complementary approach for optimized-for-risk stratification in older patients with first-ever ischemic stroke and no prior cardiovascular comorbidities. |
| first_indexed | 2024-03-13T06:08:22Z |
| format | Article |
| id | doaj.art-6525592011004dff95323528d4fee1ba |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-03-13T06:08:22Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-6525592011004dff95323528d4fee1ba2023-06-11T11:24:53ZengBMCBMC Geriatrics1471-23182023-06-0123111010.1186/s12877-023-04041-7Association of triglyceride-glucose index with myocardial injury post-stroke in older patients with first-ever ischemic strokeMu Niu0Zhikang Zhou1Long Wang2Jian Yang3Miao Sun4Xin Lv5Faqiang Zhang6Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou Medical UniversityDepartment of Anesthesiology, The First Medical Center, Chinese PLA General HospitalDepartment of Pain Medicine, The First Medical Center, Chinese PLA General HospitalDepartment of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou Medical UniversityDepartment of Anesthesiology, The First Medical Center, Chinese PLA General HospitalDepartment of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of MedicineDepartment of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of MedicineAbstract Background Myocardial injury post-stroke is a common sequela of acute stroke. Triglyceride-glucose index (TyG index), a valuable surrogate indicator of insulin resistance, has been suggested to be closely related to cardiovascular outcomes. However, it is unknown whether the TyG index is independently associated with a higher risk of myocardial injury post-stroke. We therefore investigated the longitudinal association between TyG index and risk of myocardial injury post-stroke in older patients with first-ever ischemic stroke and no prior cardiovascular comorbidities. Methods We included older patients with first-ever ischemic stroke and no prior cardiovascular comorbidities between January 2021 to December 2021. The individuals were stratified into low and high TyG index groups according to the optimal cutoff value with TyG index. We performed logistic regression analysis, propensity score matching (PSM) analysis, restricted cubic spline analysis, and subgroup analyses to explore the longitudinal association between TyG index and risk of myocardial injury post-stroke. Results We included 386 individuals with a median age of 69.8 years (interquartile range: 66.6, 75.3). The optimal TyG index cut-off for predicting myocardial injury post-stroke was 8.9 (sensitivity 67.8%; specificity 75.5%; area under curve 0.701). Multivariate logistic regression analysis revealed that the risk of genesis of myocardial injury post-stroke increased with elevated TyG index (odds ratio [OR], 2.333; 95% confidence interval [CI], 1.201–4.585; P = 0.013). Furthermore, all covariates were well balanced between the two groups. The longitudinal association between TyG index and myocardial injury post-stroke remained significantly robust (OR: 2.196; 95% CI: 1.416–3.478; P < 0.001) after PSM adjustment. Conclusion Individuals with an elevated TyG index were more susceptible to having an increased risk of myocardial injury post-stroke. TyG index thus might be served as a complementary approach for optimized-for-risk stratification in older patients with first-ever ischemic stroke and no prior cardiovascular comorbidities.https://doi.org/10.1186/s12877-023-04041-7Triglyceride-glucose index (TyG index)Myocardial injury post-strokeInsulin resistanceOlder patientsBiomarker |
| spellingShingle | Mu Niu Zhikang Zhou Long Wang Jian Yang Miao Sun Xin Lv Faqiang Zhang Association of triglyceride-glucose index with myocardial injury post-stroke in older patients with first-ever ischemic stroke BMC Geriatrics Triglyceride-glucose index (TyG index) Myocardial injury post-stroke Insulin resistance Older patients Biomarker |
| title | Association of triglyceride-glucose index with myocardial injury post-stroke in older patients with first-ever ischemic stroke |
| title_full | Association of triglyceride-glucose index with myocardial injury post-stroke in older patients with first-ever ischemic stroke |
| title_fullStr | Association of triglyceride-glucose index with myocardial injury post-stroke in older patients with first-ever ischemic stroke |
| title_full_unstemmed | Association of triglyceride-glucose index with myocardial injury post-stroke in older patients with first-ever ischemic stroke |
| title_short | Association of triglyceride-glucose index with myocardial injury post-stroke in older patients with first-ever ischemic stroke |
| title_sort | association of triglyceride glucose index with myocardial injury post stroke in older patients with first ever ischemic stroke |
| topic | Triglyceride-glucose index (TyG index) Myocardial injury post-stroke Insulin resistance Older patients Biomarker |
| url | https://doi.org/10.1186/s12877-023-04041-7 |
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