TESLA Trial: Rationale, Protocol, and Design
Background Mechanical thrombectomy has been shown to be effective in patients with acute ischemic stroke secondary to large‐vessel occlusion and small to moderate infarct volume. However, there are no randomized clinical trials for large‐core infarct volume comparing mechanical thrombectomy to medic...
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| Format: | Article |
| Language: | English |
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Wiley
2023-07-01
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| Series: | Stroke: Vascular and Interventional Neurology |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/SVIN.122.000787 |
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| author | Osama O. Zaidat Sami Al Kasab Sunil Sheth Santiago Ortega‐Gutierrez Ansaar T. Rai Curtis A. Given Ramesh Grandhi Maxim Mokin Jeffrey M. Katz Alberto Maud Rishi Gupta Wade S. Smith Diederik W. Dippel Daryl Gress Thanh N. Nguyen Scott Brown Ashutosh P. Jadhav Lucas Eljovich Charles Majoie Mary S. Patterson Hannah Slight Kristine Below Albert J. Yoo |
| author_facet | Osama O. Zaidat Sami Al Kasab Sunil Sheth Santiago Ortega‐Gutierrez Ansaar T. Rai Curtis A. Given Ramesh Grandhi Maxim Mokin Jeffrey M. Katz Alberto Maud Rishi Gupta Wade S. Smith Diederik W. Dippel Daryl Gress Thanh N. Nguyen Scott Brown Ashutosh P. Jadhav Lucas Eljovich Charles Majoie Mary S. Patterson Hannah Slight Kristine Below Albert J. Yoo |
| author_sort | Osama O. Zaidat |
| collection | DOAJ |
| description | Background Mechanical thrombectomy has been shown to be effective in patients with acute ischemic stroke secondary to large‐vessel occlusion and small to moderate infarct volume. However, there are no randomized clinical trials for large‐core infarct volume comparing mechanical thrombectomy to medical therapy in the population selected based solely on noncontrast computed tomography brain scan. The TESLA (Thrombectomy for Emergent Salvage of Large Anterior Circulation Ischemic Stroke) randomized clinical trial is designed to address this clinical question. Methods The TESLA trial aim is to demonstrate the efficacy (3‐month and 1‐year disability following stroke) and safety of intraarterial mechanical thrombectomy in patients with large‐volume infarction assessed with a noncontrast computed tomography scan. The TESLA trial design is a prospective, randomized controlled, multicenter, open‐label, assessor‐blinded anterior circulation acute ischemic stroke trial with adaptive enrichment design, enrolling up to 300 patients. Patients with anterior circulation large‐vessel occlusion who meet the imaging and clinical eligibility criteria with a large‐core infarction on the basis of noncontrast computed tomography Alberta Stroke Program Early CT Score (2–5) adjudicated by a site investigator will be randomized in a 1:1 ratio to undergo intraarterial thrombectomy or best medical management up to 24 hours from last known well. Results The primary efficacy outcome is utility‐weighted modified Rankin Scale (mRS) score distribution at 90 days between the groups. The results will be based on an intention‐to‐treat analysis that will examine the Bayesian posterior probability that, adjusted for Alberta Stroke Program Early CT Score, patients with large‐core infarct volume treated with intra‐arterial thrombectomy have higher expected utility‐weighted mRS than those treated with best medical management alone. The primary safety outcome is the 90‐day death rate. Key secondary outcomes are dichotomized mRS 0 to 2 and 0 to 3 outcomes, ordinal mRS scores, and quality of life (EuroQol 5 Dimension 5 Level survey) at 90 days and 1 year, utility‐weighted mRS at 1 year, hemicraniectomy rate, and rate of 24‐hour symptomatic intracranial hemorrhage in both groups. Conclusion TESLA is a pragmatic trial, designed to address the unanswered question of the efficacy and safety of intra‐arterial thrombectomy in patients with large infarcts diagnosed by the site investigator only on noncontrast computed tomography scan secondary to anterior circulation large‐vessel occlusion up to 24 hours from stroke symptoms onset. |
| first_indexed | 2024-03-13T01:22:17Z |
| format | Article |
| id | doaj.art-6528820818ee437bb37a153204681ca6 |
| institution | Directory Open Access Journal |
| issn | 2694-5746 |
| language | English |
| last_indexed | 2024-03-13T01:22:17Z |
| publishDate | 2023-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stroke: Vascular and Interventional Neurology |
| spelling | doaj.art-6528820818ee437bb37a153204681ca62023-07-04T18:29:17ZengWileyStroke: Vascular and Interventional Neurology2694-57462023-07-013410.1161/SVIN.122.000787TESLA Trial: Rationale, Protocol, and DesignOsama O. Zaidat0Sami Al Kasab1Sunil Sheth2Santiago Ortega‐Gutierrez3Ansaar T. Rai4Curtis A. Given5Ramesh Grandhi6Maxim Mokin7Jeffrey M. Katz8Alberto Maud9Rishi Gupta10Wade S. Smith11Diederik W. Dippel12Daryl Gress13Thanh N. Nguyen14Scott Brown15Ashutosh P. Jadhav16Lucas Eljovich17Charles Majoie18Mary S. Patterson19Hannah Slight20Kristine Below21Albert J. Yoo22Neuroscience Institute Bon Secours Mercy Health St. Vincent Hospital Toledo OHMedical University of South Carolina Charleston IAUT Health McGovern Medical School Houston TXUniversity of Iowa Hospitals and Clinics Iowa IARockefeller Neuroscience Institute West Virginia University Morgantown WVBaptist Healthy System Lexington KYUniversity of Utah Medical School Salt Lake City UTUniversity of South Florida Medical School Tampa FLNorthwell Medical Center Manhasset NYTexas Tech University Health Science Center at El Paso El Paso TXWell Star Health Atlanta GAUniversity of California San Francisco San Francisco CAErasmus University Medical Center The Randstad Rotterdam NA NetherlandsNebraska Medical Center Omaha NEBoston Medical Center Boston MAAltair Biostatistics St. Louis Park MNBarrow Neurological Institute Phoenix AZUniversity of Tennessee Memphis TNAmsterdam University Medical Center Amsterdam NetherlandsNeuroscience Institute Bon Secours Mercy Health St. Vincent Hospital Toledo OHNeuroscience Institute Bon Secours Mercy Health St. Vincent Hospital Toledo OHNeuroscience Institute Bon Secours Mercy Health St. Vincent Hospital Toledo OHTexas Stroke Institute Dallas TXBackground Mechanical thrombectomy has been shown to be effective in patients with acute ischemic stroke secondary to large‐vessel occlusion and small to moderate infarct volume. However, there are no randomized clinical trials for large‐core infarct volume comparing mechanical thrombectomy to medical therapy in the population selected based solely on noncontrast computed tomography brain scan. The TESLA (Thrombectomy for Emergent Salvage of Large Anterior Circulation Ischemic Stroke) randomized clinical trial is designed to address this clinical question. Methods The TESLA trial aim is to demonstrate the efficacy (3‐month and 1‐year disability following stroke) and safety of intraarterial mechanical thrombectomy in patients with large‐volume infarction assessed with a noncontrast computed tomography scan. The TESLA trial design is a prospective, randomized controlled, multicenter, open‐label, assessor‐blinded anterior circulation acute ischemic stroke trial with adaptive enrichment design, enrolling up to 300 patients. Patients with anterior circulation large‐vessel occlusion who meet the imaging and clinical eligibility criteria with a large‐core infarction on the basis of noncontrast computed tomography Alberta Stroke Program Early CT Score (2–5) adjudicated by a site investigator will be randomized in a 1:1 ratio to undergo intraarterial thrombectomy or best medical management up to 24 hours from last known well. Results The primary efficacy outcome is utility‐weighted modified Rankin Scale (mRS) score distribution at 90 days between the groups. The results will be based on an intention‐to‐treat analysis that will examine the Bayesian posterior probability that, adjusted for Alberta Stroke Program Early CT Score, patients with large‐core infarct volume treated with intra‐arterial thrombectomy have higher expected utility‐weighted mRS than those treated with best medical management alone. The primary safety outcome is the 90‐day death rate. Key secondary outcomes are dichotomized mRS 0 to 2 and 0 to 3 outcomes, ordinal mRS scores, and quality of life (EuroQol 5 Dimension 5 Level survey) at 90 days and 1 year, utility‐weighted mRS at 1 year, hemicraniectomy rate, and rate of 24‐hour symptomatic intracranial hemorrhage in both groups. Conclusion TESLA is a pragmatic trial, designed to address the unanswered question of the efficacy and safety of intra‐arterial thrombectomy in patients with large infarcts diagnosed by the site investigator only on noncontrast computed tomography scan secondary to anterior circulation large‐vessel occlusion up to 24 hours from stroke symptoms onset.https://www.ahajournals.org/doi/10.1161/SVIN.122.000787clinical trialdesignlarge‐core infarctlarge‐vessel occlusionstrokeTESLA trial |
| spellingShingle | Osama O. Zaidat Sami Al Kasab Sunil Sheth Santiago Ortega‐Gutierrez Ansaar T. Rai Curtis A. Given Ramesh Grandhi Maxim Mokin Jeffrey M. Katz Alberto Maud Rishi Gupta Wade S. Smith Diederik W. Dippel Daryl Gress Thanh N. Nguyen Scott Brown Ashutosh P. Jadhav Lucas Eljovich Charles Majoie Mary S. Patterson Hannah Slight Kristine Below Albert J. Yoo TESLA Trial: Rationale, Protocol, and Design Stroke: Vascular and Interventional Neurology clinical trial design large‐core infarct large‐vessel occlusion stroke TESLA trial |
| title | TESLA Trial: Rationale, Protocol, and Design |
| title_full | TESLA Trial: Rationale, Protocol, and Design |
| title_fullStr | TESLA Trial: Rationale, Protocol, and Design |
| title_full_unstemmed | TESLA Trial: Rationale, Protocol, and Design |
| title_short | TESLA Trial: Rationale, Protocol, and Design |
| title_sort | tesla trial rationale protocol and design |
| topic | clinical trial design large‐core infarct large‐vessel occlusion stroke TESLA trial |
| url | https://www.ahajournals.org/doi/10.1161/SVIN.122.000787 |
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