Acute pancreatitis following L-asparaginase in acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) is the most frequent malignancy in children,representing 25–30% of all childhood malignancies. Although treatment outcome has improved owing to advances in chemotherapy, there is still a group of patients who experience severe adverse events. L-Asparaginase is an e...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Leukemia Research Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213048922000681 |
| _version_ | 1811299669247000576 |
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| author | Soulaimane M'harzi Aziza Elouali Karim Lahrache Ayad Ghanam Abdeladim Babakhouya Maria Rkain Noufissa Benajiba |
| author_facet | Soulaimane M'harzi Aziza Elouali Karim Lahrache Ayad Ghanam Abdeladim Babakhouya Maria Rkain Noufissa Benajiba |
| author_sort | Soulaimane M'harzi |
| collection | DOAJ |
| description | Acute lymphoblastic leukemia (ALL) is the most frequent malignancy in children,representing 25–30% of all childhood malignancies. Although treatment outcome has improved owing to advances in chemotherapy, there is still a group of patients who experience severe adverse events. L-Asparaginase is an effective antineoplastic agent used in chemotherapy of ALL. Despite its indisputable indication, it can cause various adverse effects, including acute pancreatitis (AP). Recently, an increase in the number of pediatric AP cases following L-Asparaginase in Acute Lymphoblastic Leukemia been reported. We presented a case of acute pancreatitis in children with ALL induced by administration of L-ASPA preparations. |
| first_indexed | 2024-04-13T06:39:23Z |
| format | Article |
| id | doaj.art-6529182c94474a7a94f4e69a94a424d9 |
| institution | Directory Open Access Journal |
| issn | 2213-0489 |
| language | English |
| last_indexed | 2024-04-13T06:39:23Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Leukemia Research Reports |
| spelling | doaj.art-6529182c94474a7a94f4e69a94a424d92022-12-22T02:57:47ZengElsevierLeukemia Research Reports2213-04892022-01-0118100357Acute pancreatitis following L-asparaginase in acute lymphoblastic leukemiaSoulaimane M'harzi0Aziza Elouali1Karim Lahrache2Ayad Ghanam3Abdeladim Babakhouya4Maria Rkain5Noufissa Benajiba6Faculty of Medicine and Pharmacy of Oujda, Mohammed I University of Oujda, Morocco; Department of Pediatrics, Mohammed VI University Hospital of Oujda, Morocco; Corresponding author.Faculty of Medicine and Pharmacy of Oujda, Mohammed I University of Oujda, Morocco; Department of Pediatrics, Mohammed VI University Hospital of Oujda, MoroccoFaculty of Medicine and Pharmacy of Oujda, Mohammed I University of Oujda, Morocco; Department of Pediatrics, Mohammed VI University Hospital of Oujda, MoroccoFaculty of Medicine and Pharmacy of Oujda, Mohammed I University of Oujda, Morocco; Department of Pediatrics, Mohammed VI University Hospital of Oujda, MoroccoFaculty of Medicine and Pharmacy of Oujda, Mohammed I University of Oujda, Morocco; Department of Pediatrics, Mohammed VI University Hospital of Oujda, MoroccoDepartment of Pediatrics, Mohammed VI University Hospital of Oujda, MoroccoFaculty of Medicine and Pharmacy of Oujda, Mohammed I University of Oujda, Morocco; Department of Pediatrics, Mohammed VI University Hospital of Oujda, MoroccoAcute lymphoblastic leukemia (ALL) is the most frequent malignancy in children,representing 25–30% of all childhood malignancies. Although treatment outcome has improved owing to advances in chemotherapy, there is still a group of patients who experience severe adverse events. L-Asparaginase is an effective antineoplastic agent used in chemotherapy of ALL. Despite its indisputable indication, it can cause various adverse effects, including acute pancreatitis (AP). Recently, an increase in the number of pediatric AP cases following L-Asparaginase in Acute Lymphoblastic Leukemia been reported. We presented a case of acute pancreatitis in children with ALL induced by administration of L-ASPA preparations.http://www.sciencedirect.com/science/article/pii/S2213048922000681Acute pancreatitisL-asparaginaseALL |
| spellingShingle | Soulaimane M'harzi Aziza Elouali Karim Lahrache Ayad Ghanam Abdeladim Babakhouya Maria Rkain Noufissa Benajiba Acute pancreatitis following L-asparaginase in acute lymphoblastic leukemia Leukemia Research Reports Acute pancreatitis L-asparaginase ALL |
| title | Acute pancreatitis following L-asparaginase in acute lymphoblastic leukemia |
| title_full | Acute pancreatitis following L-asparaginase in acute lymphoblastic leukemia |
| title_fullStr | Acute pancreatitis following L-asparaginase in acute lymphoblastic leukemia |
| title_full_unstemmed | Acute pancreatitis following L-asparaginase in acute lymphoblastic leukemia |
| title_short | Acute pancreatitis following L-asparaginase in acute lymphoblastic leukemia |
| title_sort | acute pancreatitis following l asparaginase in acute lymphoblastic leukemia |
| topic | Acute pancreatitis L-asparaginase ALL |
| url | http://www.sciencedirect.com/science/article/pii/S2213048922000681 |
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