Associations between air pollutants and blood pressure in an ethnically diverse cohort of adolescents in London, England
Longitudinal evidence on the association between air pollution and blood pressure (BP) in adolescence is scarce. We explored this association in an ethnically diverse cohort of schoolchildren. Sex-stratified, linear random-effects modelling was used to examine how modelled residential exposure to an...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2023-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907839/?tool=EBI |
| _version_ | 1811167178029793280 |
|---|---|
| author | A. Karamanos Y. Lu I. S. Mudway S. Ayis F. J. Kelly S. D. Beevers D. Dajnak D. Fecht C. Elia S. Tandon A. J. Webb A. J. Grande O. R. Molaodi M. J. Maynard J. K. Cruickshank S. Harding |
| author_facet | A. Karamanos Y. Lu I. S. Mudway S. Ayis F. J. Kelly S. D. Beevers D. Dajnak D. Fecht C. Elia S. Tandon A. J. Webb A. J. Grande O. R. Molaodi M. J. Maynard J. K. Cruickshank S. Harding |
| author_sort | A. Karamanos |
| collection | DOAJ |
| description | Longitudinal evidence on the association between air pollution and blood pressure (BP) in adolescence is scarce. We explored this association in an ethnically diverse cohort of schoolchildren. Sex-stratified, linear random-effects modelling was used to examine how modelled residential exposure to annual average nitrogen dioxide (NO2), particulate matter (PM2.5, PM10) and ozone (O3), measures in μg/m3, associated with blood pressure. Estimates were based on 3,284 adolescents; 80% from ethnic minority groups, recruited from 51 schools, and followed up from 11–13 to 14–16 years old. Ethnic minorities were exposed to higher modelled annual average concentrations of pollution at residential postcode level than their White UK peers. A two-pollutant model (NO2 & PM2.5), adjusted for ethnicity, age, anthropometry, and pubertal status, highlighted associations with systolic, but not diastolic BP. A μg/m3 increase in NO2 was associated with a 0.30 mmHg (95% CI 0.18 to 0.40) decrease in systolic BP for girls and 0.19 mmHg (95% CI 0.07 to 0.31) decrease in systolic BP for boys. In contrast, a 1 μg/m3 increase in PM2.5 was associated with 1.34 mmHg (95% CI 0.85 to 1.82) increase in systolic BP for girls and 0.57 mmHg (95% CI 0.04 to 1.03) increase in systolic BP for boys. Associations did not vary by ethnicity, body size or socio-economic advantage. Associations were robust to adjustments for noise levels and lung function at 11–13 years. In summary, higher ambient levels of NO2 were associated with lower and PM2.5 with higher systolic BP across adolescence, with stronger associations for girls. |
| first_indexed | 2024-04-10T16:04:48Z |
| format | Article |
| id | doaj.art-6529ae3d65964f78831516ae95e6266e |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-10T16:04:48Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-6529ae3d65964f78831516ae95e6266e2023-02-10T05:31:50ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01182Associations between air pollutants and blood pressure in an ethnically diverse cohort of adolescents in London, EnglandA. KaramanosY. LuI. S. MudwayS. AyisF. J. KellyS. D. BeeversD. DajnakD. FechtC. EliaS. TandonA. J. WebbA. J. GrandeO. R. MolaodiM. J. MaynardJ. K. CruickshankS. HardingLongitudinal evidence on the association between air pollution and blood pressure (BP) in adolescence is scarce. We explored this association in an ethnically diverse cohort of schoolchildren. Sex-stratified, linear random-effects modelling was used to examine how modelled residential exposure to annual average nitrogen dioxide (NO2), particulate matter (PM2.5, PM10) and ozone (O3), measures in μg/m3, associated with blood pressure. Estimates were based on 3,284 adolescents; 80% from ethnic minority groups, recruited from 51 schools, and followed up from 11–13 to 14–16 years old. Ethnic minorities were exposed to higher modelled annual average concentrations of pollution at residential postcode level than their White UK peers. A two-pollutant model (NO2 & PM2.5), adjusted for ethnicity, age, anthropometry, and pubertal status, highlighted associations with systolic, but not diastolic BP. A μg/m3 increase in NO2 was associated with a 0.30 mmHg (95% CI 0.18 to 0.40) decrease in systolic BP for girls and 0.19 mmHg (95% CI 0.07 to 0.31) decrease in systolic BP for boys. In contrast, a 1 μg/m3 increase in PM2.5 was associated with 1.34 mmHg (95% CI 0.85 to 1.82) increase in systolic BP for girls and 0.57 mmHg (95% CI 0.04 to 1.03) increase in systolic BP for boys. Associations did not vary by ethnicity, body size or socio-economic advantage. Associations were robust to adjustments for noise levels and lung function at 11–13 years. In summary, higher ambient levels of NO2 were associated with lower and PM2.5 with higher systolic BP across adolescence, with stronger associations for girls.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907839/?tool=EBI |
| spellingShingle | A. Karamanos Y. Lu I. S. Mudway S. Ayis F. J. Kelly S. D. Beevers D. Dajnak D. Fecht C. Elia S. Tandon A. J. Webb A. J. Grande O. R. Molaodi M. J. Maynard J. K. Cruickshank S. Harding Associations between air pollutants and blood pressure in an ethnically diverse cohort of adolescents in London, England PLoS ONE |
| title | Associations between air pollutants and blood pressure in an ethnically diverse cohort of adolescents in London, England |
| title_full | Associations between air pollutants and blood pressure in an ethnically diverse cohort of adolescents in London, England |
| title_fullStr | Associations between air pollutants and blood pressure in an ethnically diverse cohort of adolescents in London, England |
| title_full_unstemmed | Associations between air pollutants and blood pressure in an ethnically diverse cohort of adolescents in London, England |
| title_short | Associations between air pollutants and blood pressure in an ethnically diverse cohort of adolescents in London, England |
| title_sort | associations between air pollutants and blood pressure in an ethnically diverse cohort of adolescents in london england |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907839/?tool=EBI |
| work_keys_str_mv | AT akaramanos associationsbetweenairpollutantsandbloodpressureinanethnicallydiversecohortofadolescentsinlondonengland AT ylu associationsbetweenairpollutantsandbloodpressureinanethnicallydiversecohortofadolescentsinlondonengland AT ismudway associationsbetweenairpollutantsandbloodpressureinanethnicallydiversecohortofadolescentsinlondonengland AT sayis associationsbetweenairpollutantsandbloodpressureinanethnicallydiversecohortofadolescentsinlondonengland AT fjkelly associationsbetweenairpollutantsandbloodpressureinanethnicallydiversecohortofadolescentsinlondonengland AT sdbeevers associationsbetweenairpollutantsandbloodpressureinanethnicallydiversecohortofadolescentsinlondonengland AT ddajnak associationsbetweenairpollutantsandbloodpressureinanethnicallydiversecohortofadolescentsinlondonengland AT dfecht associationsbetweenairpollutantsandbloodpressureinanethnicallydiversecohortofadolescentsinlondonengland AT celia associationsbetweenairpollutantsandbloodpressureinanethnicallydiversecohortofadolescentsinlondonengland AT standon associationsbetweenairpollutantsandbloodpressureinanethnicallydiversecohortofadolescentsinlondonengland AT ajwebb associationsbetweenairpollutantsandbloodpressureinanethnicallydiversecohortofadolescentsinlondonengland AT ajgrande associationsbetweenairpollutantsandbloodpressureinanethnicallydiversecohortofadolescentsinlondonengland AT ormolaodi associationsbetweenairpollutantsandbloodpressureinanethnicallydiversecohortofadolescentsinlondonengland AT mjmaynard associationsbetweenairpollutantsandbloodpressureinanethnicallydiversecohortofadolescentsinlondonengland AT jkcruickshank associationsbetweenairpollutantsandbloodpressureinanethnicallydiversecohortofadolescentsinlondonengland AT sharding associationsbetweenairpollutantsandbloodpressureinanethnicallydiversecohortofadolescentsinlondonengland |