The prior infection with SARS-CoV-2 study (PICOV) in nursing home residents and staff - study protocol description and presentation of preliminary findings on symptoms.
Abstract Background The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has presented itself as one of the most important health concerns of the 2020’s, and hit the geriatric population the hardest. The presence of co-morbidities and immune ageing in th...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-11-01
|
| Series: | Archives of Public Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13690-021-00715-z |
| _version_ | 1818652201408528384 |
|---|---|
| author | Maria E. Goossens Kristof Y. Neven Pieter Pannus Cyril Barbezange Isabelle Thomas Steven Van Gucht Katelijne Dierick Marie-Noëlle Schmickler Mathieu Verbrugghe Nele Van Loon Kevin K Ariën Arnaud Marchant Stanislas Goriely Isabelle Desombere |
| author_facet | Maria E. Goossens Kristof Y. Neven Pieter Pannus Cyril Barbezange Isabelle Thomas Steven Van Gucht Katelijne Dierick Marie-Noëlle Schmickler Mathieu Verbrugghe Nele Van Loon Kevin K Ariën Arnaud Marchant Stanislas Goriely Isabelle Desombere |
| author_sort | Maria E. Goossens |
| collection | DOAJ |
| description | Abstract Background The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has presented itself as one of the most important health concerns of the 2020’s, and hit the geriatric population the hardest. The presence of co-morbidities and immune ageing in the elderly lead to an increased susceptibility to COVID-19, as is the case for other influenza-like illnesses (ILI) or acute respiratory tract infections (ARI). However, little is known, about the impact of a previous or current infection on the other in terms of susceptibility, immune response, and clinical course. The aim of the “Prior Infection with SARS-COV-2” (PICOV) study is to compare the time to occurrence of an ILI or ARI between participants with a confirmed past SARS-CoV-2 infection (previously infected) and those without a confirmed past infection (naïve) in residents and staff members of nursing homes. This paper describes the study design and population characteristics at baseline. Methods In 26 Belgian nursing homes, all eligible residents and staff members were invited to participate, resulting in 1,226 participants. They were classified as naïve or previously infected based on the presence of detectable SARS-CoV-2 antibodies and/or a positive RT-qPCR result before participation in the study. Symptoms from a prior SARS-CoV-2 infection between March and August 2020 were compared between previously infected residents and staff members. Results Infection naïve nursing home residents reported fewer symptoms than previously infected residents: on average 1.9 and 3.1 symptoms, respectively (p = 0.016). The same effect was observed for infection naïve staff members and previously infected staff members (3.1 and 6.1 symptoms, respectively; p <0.0001). Moreover, the antibody development after a SARS-CoV-2 infection differs between residents and staff members, as previously infected residents tend to have a higher rate of asymptomatic cases compared to previously infected staff members (20.5% compared to 12.4%; p <0.0001). Conclusions We can postulate that COVID-19 disease development and symptomatology are different between a geriatric and younger population. Therefore, the occurrence and severity of a future ILI and/or ARI might vary from resident to staff. |
| first_indexed | 2024-12-17T02:18:14Z |
| format | Article |
| id | doaj.art-652b67052c384ece8d129e39d17050d2 |
| institution | Directory Open Access Journal |
| issn | 2049-3258 |
| language | English |
| last_indexed | 2024-12-17T02:18:14Z |
| publishDate | 2021-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Archives of Public Health |
| spelling | doaj.art-652b67052c384ece8d129e39d17050d22022-12-21T22:07:19ZengBMCArchives of Public Health2049-32582021-11-0179111210.1186/s13690-021-00715-zThe prior infection with SARS-CoV-2 study (PICOV) in nursing home residents and staff - study protocol description and presentation of preliminary findings on symptoms.Maria E. Goossens0Kristof Y. Neven1Pieter Pannus2Cyril Barbezange3Isabelle Thomas4Steven Van Gucht5Katelijne Dierick6Marie-Noëlle Schmickler7Mathieu Verbrugghe8Nele Van Loon9Kevin K Ariën10Arnaud Marchant11Stanislas Goriely12Isabelle Desombere13SD Epidemiology and Public Health, SciensanoSD Epidemiology and Public Health, SciensanoSD Epidemiology and Public Health, SciensanoSD Infectious Diseases in Humans, SciensanoSD Infectious Diseases in Humans, SciensanoSD Infectious Diseases in Humans, SciensanoSD Infectious Diseases in Humans, SciensanoMensura Occupational Health ServiceMensura Occupational Health ServiceMensura Occupational Health ServiceVirology Unit, Department of Biomedical Sciences, Institute of Tropical MedicineInstitute for Medical Immunology, Université libre de BruxellesInstitute for Medical Immunology, Université libre de BruxellesSD Infectious Diseases in Humans, SciensanoAbstract Background The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has presented itself as one of the most important health concerns of the 2020’s, and hit the geriatric population the hardest. The presence of co-morbidities and immune ageing in the elderly lead to an increased susceptibility to COVID-19, as is the case for other influenza-like illnesses (ILI) or acute respiratory tract infections (ARI). However, little is known, about the impact of a previous or current infection on the other in terms of susceptibility, immune response, and clinical course. The aim of the “Prior Infection with SARS-COV-2” (PICOV) study is to compare the time to occurrence of an ILI or ARI between participants with a confirmed past SARS-CoV-2 infection (previously infected) and those without a confirmed past infection (naïve) in residents and staff members of nursing homes. This paper describes the study design and population characteristics at baseline. Methods In 26 Belgian nursing homes, all eligible residents and staff members were invited to participate, resulting in 1,226 participants. They were classified as naïve or previously infected based on the presence of detectable SARS-CoV-2 antibodies and/or a positive RT-qPCR result before participation in the study. Symptoms from a prior SARS-CoV-2 infection between March and August 2020 were compared between previously infected residents and staff members. Results Infection naïve nursing home residents reported fewer symptoms than previously infected residents: on average 1.9 and 3.1 symptoms, respectively (p = 0.016). The same effect was observed for infection naïve staff members and previously infected staff members (3.1 and 6.1 symptoms, respectively; p <0.0001). Moreover, the antibody development after a SARS-CoV-2 infection differs between residents and staff members, as previously infected residents tend to have a higher rate of asymptomatic cases compared to previously infected staff members (20.5% compared to 12.4%; p <0.0001). Conclusions We can postulate that COVID-19 disease development and symptomatology are different between a geriatric and younger population. Therefore, the occurrence and severity of a future ILI and/or ARI might vary from resident to staff.https://doi.org/10.1186/s13690-021-00715-zSARS-CoV-2COVID-19ILIARIMulticentricCohort |
| spellingShingle | Maria E. Goossens Kristof Y. Neven Pieter Pannus Cyril Barbezange Isabelle Thomas Steven Van Gucht Katelijne Dierick Marie-Noëlle Schmickler Mathieu Verbrugghe Nele Van Loon Kevin K Ariën Arnaud Marchant Stanislas Goriely Isabelle Desombere The prior infection with SARS-CoV-2 study (PICOV) in nursing home residents and staff - study protocol description and presentation of preliminary findings on symptoms. Archives of Public Health SARS-CoV-2 COVID-19 ILI ARI Multicentric Cohort |
| title | The prior infection with SARS-CoV-2 study (PICOV) in nursing home residents and staff - study protocol description and presentation of preliminary findings on symptoms. |
| title_full | The prior infection with SARS-CoV-2 study (PICOV) in nursing home residents and staff - study protocol description and presentation of preliminary findings on symptoms. |
| title_fullStr | The prior infection with SARS-CoV-2 study (PICOV) in nursing home residents and staff - study protocol description and presentation of preliminary findings on symptoms. |
| title_full_unstemmed | The prior infection with SARS-CoV-2 study (PICOV) in nursing home residents and staff - study protocol description and presentation of preliminary findings on symptoms. |
| title_short | The prior infection with SARS-CoV-2 study (PICOV) in nursing home residents and staff - study protocol description and presentation of preliminary findings on symptoms. |
| title_sort | prior infection with sars cov 2 study picov in nursing home residents and staff study protocol description and presentation of preliminary findings on symptoms |
| topic | SARS-CoV-2 COVID-19 ILI ARI Multicentric Cohort |
| url | https://doi.org/10.1186/s13690-021-00715-z |
| work_keys_str_mv | AT mariaegoossens thepriorinfectionwithsarscov2studypicovinnursinghomeresidentsandstaffstudyprotocoldescriptionandpresentationofpreliminaryfindingsonsymptoms AT kristofyneven thepriorinfectionwithsarscov2studypicovinnursinghomeresidentsandstaffstudyprotocoldescriptionandpresentationofpreliminaryfindingsonsymptoms AT pieterpannus thepriorinfectionwithsarscov2studypicovinnursinghomeresidentsandstaffstudyprotocoldescriptionandpresentationofpreliminaryfindingsonsymptoms AT cyrilbarbezange thepriorinfectionwithsarscov2studypicovinnursinghomeresidentsandstaffstudyprotocoldescriptionandpresentationofpreliminaryfindingsonsymptoms AT isabellethomas thepriorinfectionwithsarscov2studypicovinnursinghomeresidentsandstaffstudyprotocoldescriptionandpresentationofpreliminaryfindingsonsymptoms AT stevenvangucht thepriorinfectionwithsarscov2studypicovinnursinghomeresidentsandstaffstudyprotocoldescriptionandpresentationofpreliminaryfindingsonsymptoms AT katelijnedierick thepriorinfectionwithsarscov2studypicovinnursinghomeresidentsandstaffstudyprotocoldescriptionandpresentationofpreliminaryfindingsonsymptoms AT marienoelleschmickler thepriorinfectionwithsarscov2studypicovinnursinghomeresidentsandstaffstudyprotocoldescriptionandpresentationofpreliminaryfindingsonsymptoms AT mathieuverbrugghe thepriorinfectionwithsarscov2studypicovinnursinghomeresidentsandstaffstudyprotocoldescriptionandpresentationofpreliminaryfindingsonsymptoms AT nelevanloon thepriorinfectionwithsarscov2studypicovinnursinghomeresidentsandstaffstudyprotocoldescriptionandpresentationofpreliminaryfindingsonsymptoms AT kevinkarien thepriorinfectionwithsarscov2studypicovinnursinghomeresidentsandstaffstudyprotocoldescriptionandpresentationofpreliminaryfindingsonsymptoms AT arnaudmarchant thepriorinfectionwithsarscov2studypicovinnursinghomeresidentsandstaffstudyprotocoldescriptionandpresentationofpreliminaryfindingsonsymptoms AT stanislasgoriely thepriorinfectionwithsarscov2studypicovinnursinghomeresidentsandstaffstudyprotocoldescriptionandpresentationofpreliminaryfindingsonsymptoms AT isabelledesombere thepriorinfectionwithsarscov2studypicovinnursinghomeresidentsandstaffstudyprotocoldescriptionandpresentationofpreliminaryfindingsonsymptoms AT mariaegoossens priorinfectionwithsarscov2studypicovinnursinghomeresidentsandstaffstudyprotocoldescriptionandpresentationofpreliminaryfindingsonsymptoms AT kristofyneven priorinfectionwithsarscov2studypicovinnursinghomeresidentsandstaffstudyprotocoldescriptionandpresentationofpreliminaryfindingsonsymptoms AT pieterpannus priorinfectionwithsarscov2studypicovinnursinghomeresidentsandstaffstudyprotocoldescriptionandpresentationofpreliminaryfindingsonsymptoms AT cyrilbarbezange priorinfectionwithsarscov2studypicovinnursinghomeresidentsandstaffstudyprotocoldescriptionandpresentationofpreliminaryfindingsonsymptoms AT isabellethomas priorinfectionwithsarscov2studypicovinnursinghomeresidentsandstaffstudyprotocoldescriptionandpresentationofpreliminaryfindingsonsymptoms AT stevenvangucht priorinfectionwithsarscov2studypicovinnursinghomeresidentsandstaffstudyprotocoldescriptionandpresentationofpreliminaryfindingsonsymptoms AT katelijnedierick priorinfectionwithsarscov2studypicovinnursinghomeresidentsandstaffstudyprotocoldescriptionandpresentationofpreliminaryfindingsonsymptoms AT marienoelleschmickler priorinfectionwithsarscov2studypicovinnursinghomeresidentsandstaffstudyprotocoldescriptionandpresentationofpreliminaryfindingsonsymptoms AT mathieuverbrugghe priorinfectionwithsarscov2studypicovinnursinghomeresidentsandstaffstudyprotocoldescriptionandpresentationofpreliminaryfindingsonsymptoms AT nelevanloon priorinfectionwithsarscov2studypicovinnursinghomeresidentsandstaffstudyprotocoldescriptionandpresentationofpreliminaryfindingsonsymptoms AT kevinkarien priorinfectionwithsarscov2studypicovinnursinghomeresidentsandstaffstudyprotocoldescriptionandpresentationofpreliminaryfindingsonsymptoms AT arnaudmarchant priorinfectionwithsarscov2studypicovinnursinghomeresidentsandstaffstudyprotocoldescriptionandpresentationofpreliminaryfindingsonsymptoms AT stanislasgoriely priorinfectionwithsarscov2studypicovinnursinghomeresidentsandstaffstudyprotocoldescriptionandpresentationofpreliminaryfindingsonsymptoms AT isabelledesombere priorinfectionwithsarscov2studypicovinnursinghomeresidentsandstaffstudyprotocoldescriptionandpresentationofpreliminaryfindingsonsymptoms |