Regular fecal microbiota transplantation to Senescence Accelerated Mouse-Prone 8 (SAMP8) mice delayed the aging of locomotor and exploration ability by rejuvenating the gut microbiota
Recent evidence points out the role of the gut microbiota in the aging process. However, the specific changes and relevant interventions remain unclear. In this study, Senescence Accelerated Mouse-Prone 8 (SAMP8) mice were divided into four groups; young-FMT-group transplanted fecal microbiota from...
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.991157/full |
| _version_ | 1811205046147219456 |
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| author | Nana Zhang Nana Zhang Yan Zhang Yan Zhang Zikai Wang Fei Pan Rongrong Ren Zhengpeng Li Huijun Zhao Xi Luo Zongwei Li Lei Wang Rui Mo Gang Sun Lihua Peng Ming Ni Yunsheng Yang Yunsheng Yang |
| author_facet | Nana Zhang Nana Zhang Yan Zhang Yan Zhang Zikai Wang Fei Pan Rongrong Ren Zhengpeng Li Huijun Zhao Xi Luo Zongwei Li Lei Wang Rui Mo Gang Sun Lihua Peng Ming Ni Yunsheng Yang Yunsheng Yang |
| author_sort | Nana Zhang |
| collection | DOAJ |
| description | Recent evidence points out the role of the gut microbiota in the aging process. However, the specific changes and relevant interventions remain unclear. In this study, Senescence Accelerated Mouse-Prone 8 (SAMP8) mice were divided into four groups; young-FMT-group transplanted fecal microbiota from young donors (2–3°months old) and old-FMT-group transplanted from old donors (10–11°months old); additionally, other two groups either adult mice injected with saline solution or untreated mice served as the saline and blank control groups, respectively. All mice were intervened from their 7-months-old until 13-months-old. The open field test at 9 and 11°months of age showed that the mice transplanted with gut microbiota from young donors had significantly better locomotor and exploration ability than those of transplanted with old-donors gut microbiota and those of saline control while was comparable with the blank control. 16S rRNA gene sequencing showed that the gut microbiome of recipient mice of young donors was altered at 11°months of age, whereas the alternation of the gut microbiome of old-donor recipient mice was at 9°months. For comparison, the recipient mice in the blank and saline control groups exhibited changes in the gut microbiome at 10°months of age. The hallmark of aging-related gut microbiome change was an increase in the relative abundance of Akkermansia, which was significantly higher in the recipients transplanted with feces from older donors than younger donors at 9°months of age. This study shows that fecal microbiota transplantation from younger donors can delay aging-related declines in locomotor and exploration ability in mice by changing the gut microbiome. |
| first_indexed | 2024-04-12T03:24:01Z |
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| id | doaj.art-652b8cf9c6a0492f937b7bc8597de1d7 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-12T03:24:01Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-652b8cf9c6a0492f937b7bc8597de1d72022-12-22T03:49:46ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-10-011410.3389/fnagi.2022.991157991157Regular fecal microbiota transplantation to Senescence Accelerated Mouse-Prone 8 (SAMP8) mice delayed the aging of locomotor and exploration ability by rejuvenating the gut microbiotaNana Zhang0Nana Zhang1Yan Zhang2Yan Zhang3Zikai Wang4Fei Pan5Rongrong Ren6Zhengpeng Li7Huijun Zhao8Xi Luo9Zongwei Li10Lei Wang11Rui Mo12Gang Sun13Lihua Peng14Ming Ni15Yunsheng Yang16Yunsheng Yang17Medical School of Chinese PLA, Beijing, ChinaMicrobiota Division, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaMicrobiota Division, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaInstitute of Health Service and Transfusion Medicine, Beijing, ChinaMicrobiota Division, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaMicrobiota Division, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaMicrobiota Division, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaMicrobiota Division, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaMicrobiota Division, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaMicrobiota Division, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaMicrobiota Division, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaMicrobiota Division, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaMicrobiota Division, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaMicrobiota Division, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaMicrobiota Division, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaInstitute of Health Service and Transfusion Medicine, Beijing, ChinaMicrobiota Division, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaNational Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, ChinaRecent evidence points out the role of the gut microbiota in the aging process. However, the specific changes and relevant interventions remain unclear. In this study, Senescence Accelerated Mouse-Prone 8 (SAMP8) mice were divided into four groups; young-FMT-group transplanted fecal microbiota from young donors (2–3°months old) and old-FMT-group transplanted from old donors (10–11°months old); additionally, other two groups either adult mice injected with saline solution or untreated mice served as the saline and blank control groups, respectively. All mice were intervened from their 7-months-old until 13-months-old. The open field test at 9 and 11°months of age showed that the mice transplanted with gut microbiota from young donors had significantly better locomotor and exploration ability than those of transplanted with old-donors gut microbiota and those of saline control while was comparable with the blank control. 16S rRNA gene sequencing showed that the gut microbiome of recipient mice of young donors was altered at 11°months of age, whereas the alternation of the gut microbiome of old-donor recipient mice was at 9°months. For comparison, the recipient mice in the blank and saline control groups exhibited changes in the gut microbiome at 10°months of age. The hallmark of aging-related gut microbiome change was an increase in the relative abundance of Akkermansia, which was significantly higher in the recipients transplanted with feces from older donors than younger donors at 9°months of age. This study shows that fecal microbiota transplantation from younger donors can delay aging-related declines in locomotor and exploration ability in mice by changing the gut microbiome.https://www.frontiersin.org/articles/10.3389/fnagi.2022.991157/fullagingfecal microbiota transplantationgut microbiotaAkkermansiaSAMP8 |
| spellingShingle | Nana Zhang Nana Zhang Yan Zhang Yan Zhang Zikai Wang Fei Pan Rongrong Ren Zhengpeng Li Huijun Zhao Xi Luo Zongwei Li Lei Wang Rui Mo Gang Sun Lihua Peng Ming Ni Yunsheng Yang Yunsheng Yang Regular fecal microbiota transplantation to Senescence Accelerated Mouse-Prone 8 (SAMP8) mice delayed the aging of locomotor and exploration ability by rejuvenating the gut microbiota Frontiers in Aging Neuroscience aging fecal microbiota transplantation gut microbiota Akkermansia SAMP8 |
| title | Regular fecal microbiota transplantation to Senescence Accelerated Mouse-Prone 8 (SAMP8) mice delayed the aging of locomotor and exploration ability by rejuvenating the gut microbiota |
| title_full | Regular fecal microbiota transplantation to Senescence Accelerated Mouse-Prone 8 (SAMP8) mice delayed the aging of locomotor and exploration ability by rejuvenating the gut microbiota |
| title_fullStr | Regular fecal microbiota transplantation to Senescence Accelerated Mouse-Prone 8 (SAMP8) mice delayed the aging of locomotor and exploration ability by rejuvenating the gut microbiota |
| title_full_unstemmed | Regular fecal microbiota transplantation to Senescence Accelerated Mouse-Prone 8 (SAMP8) mice delayed the aging of locomotor and exploration ability by rejuvenating the gut microbiota |
| title_short | Regular fecal microbiota transplantation to Senescence Accelerated Mouse-Prone 8 (SAMP8) mice delayed the aging of locomotor and exploration ability by rejuvenating the gut microbiota |
| title_sort | regular fecal microbiota transplantation to senescence accelerated mouse prone 8 samp8 mice delayed the aging of locomotor and exploration ability by rejuvenating the gut microbiota |
| topic | aging fecal microbiota transplantation gut microbiota Akkermansia SAMP8 |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.991157/full |
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