Protein-conformational diseases in childhood: Naturally-occurring hIAPP amyloid-oligomers and early β-cell damage in obesity and diabetes.

Protein-conformational diseases in childhood: Naturally-occurring hIAPP amyloid-oligomers and early β-cell damage in obesity and diabetes.

<h4>Background and aims</h4>This is the first time that obesity and diabetes mellitus (DM) as protein conformational diseases (PCD) are reported in children and they are typically diagnosed too late, when β-cell damage is evident. Here we wanted to investigate the level of naturally-ocur...

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Bibliographic Details
Main Authors: Nelly F Altamirano-Bustamante, Eulalia Garrido-Magaña, Eugenia Morán, Aurora Calderón, Karina Pasten-Hidalgo, Rosa Angélica Castillo-Rodríguez, Gerardo Rojas, Reyna Lara-Martínez, Edgar Leyva-García, Mateo Larralde-Laborde, Guadalupe Domíguez, Chiharu Murata, Yolanda Margarita-Vazquez, Rafael Payro, Manuel Barbosa, Alejandro Valderrama, Hortencia Montesinos, Alejandra Domínguez-Camacho, Víctor H García-Olmos, Regina Ferrer, Patricia G Medina-Bravo, Fernanda Santoscoy, Cristina Revilla-Monsalve, Luis Felipe Jiménez-García, Julio Morán, Jalil Villalobos-Alva, Mario Javier Villalobos, Raúl Calzada-León, Perla Altamirano, Myriam M Altamirano-Bustamante
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0237667

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