Nonadherence to treatment recommendations is a factor contributing to the clinical failure of daptomycin: Cohort study in Brazil
To evaluate the clinical outcomes of daptomycin therapy and adherence to treatment recommendations, a retrospective cohort study was conducted with patients that received daptomycin during the period of the study. The adherence and nonadherence to clinical guidelines were assessed through organism i...
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2020-11-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100583&tlng=en |
| _version_ | 1818745360148856832 |
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| author | Tathiana Silva de Souza Martins Albert Figueras Luana dos Reis de Souza Keila Cristina Oliveira dos Santos Elaine Machado de Oliveira Silvia Regina Secoli |
| author_facet | Tathiana Silva de Souza Martins Albert Figueras Luana dos Reis de Souza Keila Cristina Oliveira dos Santos Elaine Machado de Oliveira Silvia Regina Secoli |
| author_sort | Tathiana Silva de Souza Martins |
| collection | DOAJ |
| description | To evaluate the clinical outcomes of daptomycin therapy and adherence to treatment recommendations, a retrospective cohort study was conducted with patients that received daptomycin during the period of the study. The adherence and nonadherence to clinical guidelines were assessed through organism identification, dose and time of treatment, management of bacteremia, and vancomycin treatment failure. A multiple logistic regression model analyzed the association between independent variables and clinical success (dependent variable), considering 5% of statistical significance. The study presented 52 patients who received daptomycin for the treatment of bacteremia (21.1%) or infections (osteomyelitis [63.5%], synovial fluid [15.4%]). Most patients (86.5%) received daptomycin as the second line of treatment, and 51.9% achieved clinical success. The patients had a better chance of clinical success when they followed the guideline indications (OR = 16.86; 95% CI = 1.45-195.88) and the medication was prescribed by a specialist in infectious diseases (OR = 4.84; 95% CI = 1.11-21.09). The study demonstrated lower clinical success than that described in the literature because of patients who were not eligible according to the clinical guidelines. Adherence to recommendations and appropriate prescription of reserve antibiotics is important in limiting early resistance, and avoiding clinical failure and unnecessary expenditure. |
| first_indexed | 2024-12-18T02:58:58Z |
| format | Article |
| id | doaj.art-652d6c3220704a31884548772bb4ea17 |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-12-18T02:58:58Z |
| publishDate | 2020-11-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-652d6c3220704a31884548772bb4ea172022-12-21T21:23:19ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902020-11-015610.1590/s2175-97902020000117184Nonadherence to treatment recommendations is a factor contributing to the clinical failure of daptomycin: Cohort study in BrazilTathiana Silva de Souza MartinsAlbert Figuerashttps://orcid.org/0000-0002-2740-2013Luana dos Reis de SouzaKeila Cristina Oliveira dos Santoshttps://orcid.org/0000-0003-0669-0105Elaine Machado de Oliveirahttps://orcid.org/0000-0002-1975-297XSilvia Regina Secolihttps://orcid.org/0000-0003-4135-6241To evaluate the clinical outcomes of daptomycin therapy and adherence to treatment recommendations, a retrospective cohort study was conducted with patients that received daptomycin during the period of the study. The adherence and nonadherence to clinical guidelines were assessed through organism identification, dose and time of treatment, management of bacteremia, and vancomycin treatment failure. A multiple logistic regression model analyzed the association between independent variables and clinical success (dependent variable), considering 5% of statistical significance. The study presented 52 patients who received daptomycin for the treatment of bacteremia (21.1%) or infections (osteomyelitis [63.5%], synovial fluid [15.4%]). Most patients (86.5%) received daptomycin as the second line of treatment, and 51.9% achieved clinical success. The patients had a better chance of clinical success when they followed the guideline indications (OR = 16.86; 95% CI = 1.45-195.88) and the medication was prescribed by a specialist in infectious diseases (OR = 4.84; 95% CI = 1.11-21.09). The study demonstrated lower clinical success than that described in the literature because of patients who were not eligible according to the clinical guidelines. Adherence to recommendations and appropriate prescription of reserve antibiotics is important in limiting early resistance, and avoiding clinical failure and unnecessary expenditure.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100583&tlng=enDaptomycinPost marketingGram-positive bacterial infectionsOrthopedic |
| spellingShingle | Tathiana Silva de Souza Martins Albert Figueras Luana dos Reis de Souza Keila Cristina Oliveira dos Santos Elaine Machado de Oliveira Silvia Regina Secoli Nonadherence to treatment recommendations is a factor contributing to the clinical failure of daptomycin: Cohort study in Brazil Brazilian Journal of Pharmaceutical Sciences Daptomycin Post marketing Gram-positive bacterial infections Orthopedic |
| title | Nonadherence to treatment recommendations is a factor contributing to the clinical failure of daptomycin: Cohort study in Brazil |
| title_full | Nonadherence to treatment recommendations is a factor contributing to the clinical failure of daptomycin: Cohort study in Brazil |
| title_fullStr | Nonadherence to treatment recommendations is a factor contributing to the clinical failure of daptomycin: Cohort study in Brazil |
| title_full_unstemmed | Nonadherence to treatment recommendations is a factor contributing to the clinical failure of daptomycin: Cohort study in Brazil |
| title_short | Nonadherence to treatment recommendations is a factor contributing to the clinical failure of daptomycin: Cohort study in Brazil |
| title_sort | nonadherence to treatment recommendations is a factor contributing to the clinical failure of daptomycin cohort study in brazil |
| topic | Daptomycin Post marketing Gram-positive bacterial infections Orthopedic |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100583&tlng=en |
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