Complement networks in gene-edited pig xenotransplantation: enhancing transplant success and addressing organ shortage
Abstract The shortage of organs for transplantation emphasizes the urgent need for alternative solutions. Xenotransplantation has emerged as a promising option due to the greater availability of donor organs. However, significant hurdles such as hyperacute rejection and organ ischemia–reperfusion in...
Main Authors: | Yinglin Yuan, Yuanyuan Cui, Dayue Zhao, Yuan Yuan, Yanshuang Zhao, Danni Li, Xiaomei Jiang, Gaoping Zhao |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2024-04-01
|
Series: | Journal of Translational Medicine |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12967-024-05136-4 |
Similar Items
-
Cutting edge of genetically modified pigs targeting complement activation for xenotransplantation
by: Qin Sun, et al.
Published: (2024-04-01) -
Innate Immune Response Analysis in Meniscus Xenotransplantation Using Normal and Triple Knockout Jeju Native Pigs
by: Seungwon Yoon, et al.
Published: (2022-09-01) -
Multiple gene modifications of pigs for overcoming obstacles of xenotransplantation
by: Wu Han, et al.
Published: (2023-09-01) -
Chimeric Livers: Interspecies Blastocyst Complementation and Xenotransplantation for End-Stage Liver Disease
by: Blake MJ, et al.
Published: (2024-02-01) -
Establishment of a donor pig for xenotransplantation clinical trials based on the principle of Changsha Communiqué
by: Xiaoqian Ma, et al.
Published: (2023-04-01)